Lind S, Wright SC, Gvozdenovic E, Nilsson K, Granberg KL, Bouvier M, Johansson LC. Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β-arrestin recruitment and the discovery of an allosteric agonist. Br J Pharmacol. 2026 May;183(10):2219-2235.
Shah RB, Li Y, Person A, Frigon L, Ðukić N, Kini E, Chen R, Pascal JM, Cohen MS, Ahel I, Haley JD, Sidi S. PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly. Sci Adv. 2026 May;12(18):eadz9284. doi: 10.1126/sciadv.adz9284.
Biga V, Miller A, Kamath A, Lea R, Mak YQP, Adamson AD, Marinopoulou E, François P, Papalopulu N, Manning CS. Oscillatory co-expression of HES1 and HES5 Enables a hybrid state in a cross-repressive transcription factor regulatory motif. Development. 2026 May 1:dev.204969. doi: 10.1242/dev.204969.
Lalanne JB, Huynh C, Mich JK, Hunker AC, McDiarmid TA, Kim H, Levi BP, Ting JT, Shendure J. Pool-packaged AAV libraries exhibit extensive length-dependent and homology-dependent chimerism. Nat Biotechnol. 2026 Apr 28. doi: 10.1038/s41587-026-03097-1.
Cole SJ, Allen SR, Guzmán BB, Hu Y, Stormo BM, Roden CA, Ekena J, Zhang V, McLaughlin GA, Crocker AW, Laederach A, Dominguez D, Gladfelter AS. Sequence and structure of protein binding sites in RNA impact biomolecular condensates. Mol Biol Cell. 2026 Apr 23:mbcE26020083.
Chalder L, Elremaly W, Li D, Fang Y, Caraus I, Leveau C, Elbakry M, Franco A, Godbout C, Di Tomasso G, Nepotchatykh E, Rostami-Afshari B, Gimenez M, Legault P, Moreau A. PTPRN2 hypomethylation and PHB2-associated miR-153-3p maturation define dual epigenetic features linked to symptom variability in Myalgic encephalomyelitis. J Transl Med. 2026 Apr 20. doi: 10.1186/s12967-026-08162-6.
Chin A, Bergeman J, Communal L, Barutcu S, Boulais J, Yeo GW, Mes-Masson AM, Lécuyer E. Localized regulation of cell junction mRNAs is required for epithelial cell integrity. RNA. 2026 Apr 16;32(5):635-653.
Doriane Etienne, Patrick M Archambault, Isaac I Bogoch, Christine T Chambers, Andrea D Chittle, Juliette Demers, S Michelle Driedger, Ève Dubé, Marie-Pierre Gagnon, Teresa Gavaruzzi, Anik Giguère, Nathalie Grandvaux, Kelly Grindrod, Hina Hakim, Samira Jeimy, Jason Kindrachuk, Annie LeBlanc, Shannon E MacDonald, Ruth Ndjaboue, Magniol Noubi, Rita Orji, Jean-Sébastien Paquette, Elizabeth Parent, Jean-Sébastien Renaud, Beate Sander, Monica Taljaard, Dana Tannenbaum Greenberg, Marie-Claude Tremblay, Sabina Vohra-Miller, Vivian A Welch, Holly O Witteman. Interactive, Personalized Patient Decision Aid for COVID-19 Vaccination in Canada: User-Centered Design Approach. JMIR Hum Factors. 2026 Apr 16:13:e86283.
Bouchard AY, Cabana VC, Plamondon J, Li C, Vivet AJI, Mader S, Thibault P, Lussier MP, Cappadocia L. A ZNF-nanobody fusion reveals SUMOylation-dependent changes in p53 protein localization. iScience. 2026 Apr 9;29(5):115673.
Christian Poitras, Ali Harake, Nathalie Grandvaux, Benoit Coulombe. Interactys-AI: Toward AI-Driven Structural Mapping of Virus-Host Interfaces for Antiviral Repurposing and Pandemic Preparedness. Biomolecules. 2026 Apr 5;16(4):541.
Sochodolsky K, Khetchoumian K, Balsalobre A, Feeley RM, Rice ME, Chakravarty P, Lovell-Badge R, Rizzoti K, Drouin J. BDNF Regulates Pituitary Stem Cell Engagement towards precursor state. bioRxiv [Preprint]. 2026 Apr 4:2026.04.02.716194.
Andricioaei I, Best RB, Birge RR, Boresch S, Brunger A, Brooks BR, Buck M, Brüschweiler R, Caflisch A, Case DA, Cui Q, Dejaegere A, Dinner AR, Elber R, Evanseck JD, Gao J, Guo H, Hubbard RE, Kuriyan J, Joseph-McCarthy D, Levy RM, Nilsson L, Mattos C, MacKerell AD Jr, McCammon JA, Michnick SW, Mulholland A, Meuwly M, Pastor RW, Reuter N, Roux B, Sali A, Schlick T, Smith JC, Stote RH, Straub JE, Taly A, van der Vaart A, Wan S, Weiss MA, Yang W, York DM, Zhou Y. The scientific legacy of Martin Karplus from the perspective of his collaborators. Biophys J. 2026 Apr 1:S0006-3495(26)00234-1.
Hu H, Neumann H, Teplitz GM, Franco-Echevarría E, Chartrand P, Wellinger RJ, Nguyen THD. Cryo-electron microscopy structure of the budding yeast telomerase holoenzyme. Science. 2026 Mar 26;391(6792):eadz5344.
Londhe AD, Rizzo S, Rizvi SM, Bergeron A, Sagabala RS, Banavali NK, Thévenin D, Boivin B. Rational design of a protein-protein interaction inhibitor that activates Protein Tyrosine Phosphatase 1B. bioRxiv [Preprint]. 2026 Mar 21:2026.03.19.712938.
Rinnerthaler M, Sykora M, Christoforakos A, Aberger F, Ferbeyre G, Moriggl R. STAT1/3/5 Functions Driving Lipid and Energy Metabolism in Cancer and Immunity. Int J Mol Sci. 2026 Mar 20;27(6):2828.
Gaudreault J, Komsalov P, Kuipers J, Lemire L, Cass B, Lamoureux L, Leroy J, Corbeil C, Sulea T, Voyer R, Joubert S, Durocher Y, Henry O, Pham PL. CHO Cell Line Selection through Multi-Criteria Analysis Reveals Critical Impact of Gas Overlay. Biotechnol J. 2026 Mar;21(3):e70206.
Leguay K, Naffati O, Kiyan CL, He YY, Hogue M, Tesnière C, Gombos M, Kuasne H, Gaboury L, Le Gouill C, Meloche S, Bouvier M, Carréno S. TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells. Life Sci Alliance. 2026 Mar 17;9(6):e202503601.
Shirude PS, Cheney D, Chattopadhyay AK, Seshadri B, Baligar V, Rachamreddy C, Madduri S, Anjanappa P, Viet A, Valente MN, Rossi K, Abousleiman M, Hsu MY, Everlof G, Gali V, Sun Y, Allocco J, Zhang R, St-Onge S, Lupisella J, Chen XQ, Sarodaya S, Ravindran MS, Tagore DM, Nagar J, Dudhgaonkar S, Putlur S, Héroux M, Bouvier M, Wexler RR, Dierks E, Garcia RA, Kick EK, Wurtz NR. From Lead to Clinical Candidate: Discovery of BMS-986331 as a Potent and Selective N-Formyl Peptide Receptor 2 Agonist. J Med Chem. 2026 Feb 17. doi: 10.1021/acs.jmedchem.5c02712.
Sverzhinsky A, Xue H, Langelier MF, Muniz Corrêa MV, Del Mundo J, Classen S, Hammel M, Rothenberg E, Pascal JM. PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation. Nat Commun. 2026 Feb 16. doi: 10.1038/s41467-026-69375-3.
Bernier L, de Oliveira TC, Majeau JA, Plourde KV, Jacobi V, Tanguay P, de la Bastide PY, Hintz WE, Porth IM, Dufour J, Hessenauer P, Roden CA, Laflamme C, Varlet L. An Ammonium Transporter Gene Contributes to the Aggressiveness of the Dutch Elm Disease Pathogen Ophiostoma novo-ulmi. J Fungi (Basel). 2026 Feb 13;12(2):137.
Castellanos-Girouard X, Serohijos AWR, Michnick SW. Protein-protein interactions are a major source of epistasis in genetic interaction networks. Nat Commun. 2026 Feb 5. doi: 10.1038/s41467-026-69152-2.
Hassan S, Ferbeyre G. Precision targeting of the SASP in cancer therapy. Nat Aging. 2026 Feb 3. doi: 10.1038/s43587-025-01052-4.
Fernandes MGF, Pinard M, Sokullu E, Tremblay C, Gagnon JF, Calon F, Coulombe B; Consortium For The Early Identification Of Alzheimer’s Disease—Quebec (CIMA-Q); Brouillette J Dr. Differences in blood levels of neuroligin-derived peptides in a cohort for early detection of Alzheimer’s disease. J Gerontol A Biol Sci Med Sci. 2026 Feb 3:glag009.
Adams JJ, Blazer LL, Chung J, Karimi M, Davidson T, Blair B, Waddle C, Hokanson CA, Bruce HA, Singer AU, Tombak EM, Gildemann K, Tamberg N, Kiiver K, Ustav M Jr, Ma Y, Colombo L, Huang LJ, Michnick SW, Moe OW, Sidhu SS. Tetravalent antibodies are more potent and efficacious erythropoiesis-stimulating agents than erythropoietin in vivo. Protein Sci. 2026 Feb;35(2):e70462.
Lemire L, Reyes SJ, Durocher Y, Voyer R, Henry O, Pham PL. Scale-up of a monoclonal antibody CHO fed-batch production in stirred tank bioreactors: Effect of hydrodynamic conditions and feeding regimen. Biotechnol Prog. 2026 Jan-Feb;42(1):e70073.
Tamming L, Lansdell C, Zhang W, Duque D, Bavananthasivam J, Frahm G, Pfeifle A, Thulasi Raman SN, Wu J, Gravel C, Stalker A, Stuible M, Durocher Y, Chen W, Wang L, Sauve S, Tran A, Johnston MJW, Li X. Durability of DNA-LNP and mRNA-LNP vaccine-induced immunity against sars-cov-2 xbb.1.5. NPJ Vaccines. 2026 Jan 31. doi: 10.1038/s41541-026-01382-3.
Coulombe-Huntington J, Bertomeu T, Huard C, Chatr-Aryamontri A, St-Cyr DJ, Sánchez-Osuna M, Papadopoli D, Normandin K, Paydar M, McLaughlan S, St-Denis C, Zhang L, Say H, Palou R, Stark C, Breitkreutz BJ, van der Sloot AM, Manohar S, Lavoie H, Borden KLB, Raught B, D’Amours D, Sicheri F, Verreault A, Mader S, Meloche S, Therrien M, Thibault P, Wilhelm B, Dirks PB, Aitchison JD, Patton E, King RW, Roux PP, Sauvageau G, Hoang T, Marinier A, Harrington L, Kwok B, Archambault V, Topisirovic I, Tyers M. A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture. bioRxiv [Preprint]. 2026 Jan 30:2026.01.28.701823.
Gharari N, Mereu E, Luciano B, Heidari B, Mader S, Piva R. Dual Targeting of IDH2 and the Ubiquitin-Proteasome System Reveals a Functional Vulnerability in Breast Cancer Models. Cancers (Basel). 2026 Jan 24;18(3):368.
Jagdish S, Joumier L, Dhakal S, Duran-Bishop G, Usama M, Malleshaiah M. BMP and NODAL paracrine signalling regulate the totipotent-like cell state in embryonic stem cells. Front Cell Dev Biol. 2026 Jan 23;13:1720355.
Sarrasin M, Burger G, Lang BF. Eukan: a fully automated nuclear genome annotation pipeline for less studied and divergent eukaryotes. NAR Genom Bioinform. 2026 Jan 20;8(1):lqag003.
Chin A, Bergeman J, Communal L, Barutcu S, Boulais J, Yeo G, Mes-Masson AM, Lecuyer E. Localized regulation of cell junction mRNAs is required for epithelial cell integrity. RNA. 2026 Jan 14:rna.080898.125. doi: 10.1261/rna.080898.125.
Renner TM, Agbayani G, Azizi H, Deschatelets L, Dudani R, Harrison BA, Hemraz UD, Koukiekolo R, Stuible M, Durocher Y, McCluskie MJ, Akache B. Heterologous vs. homologous vaccine regimens: Sulfated lactosyl archaeol (SLA) archaeosome-adjuvanted SARS-CoV-2 spike protein boost following an mRNA/LNP prime induces robust and balanced immune responses. Vaccine. 2026 Jan 7;74:128182.
Salazar S, Delgadillo-Silva LF, Carapeto P, Kenfaoui MM, Dakessian K, Melhem R, Provencher-Girard A, Ostinelli G, Turgeon J, Kaci I, Migneault F, Huising MO, Hébert MJ, Chaker-Margot M, Rutter GA. Additive Effects of Dorzagliatin and Glucagon-Like Peptide 1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice. Diabetes. 2026 Jan 1;75(1):99-114.
O’Brien SL, Tripp E, Barki N, Blondel-Tepaz E, Smith G, Boufersaoui A, Roberts J, Pike JA, Correia J, Miljus T, Bouvier M, Tennant DA, Hudson BD, Gerhart-Hines Z, Milligan G, Schwartz TW, Calebiro D. Intracrine FFA4 signaling controls lipolysis at lipid droplets. Nat Chem Biol. 2026 Jan;22(1):109-119.
Roy K, François P. Foci, waves, excitability: Self-organization of phase waves in a model of asymmetrically coupled embryonic oscillators. Phys Rev E. 2026 Jan;113(1-1):014405.
Gerasimov ES, Valach M, Burger G, Záhonová K, Yurchenko V. Assembly and Annotation of Kinetoplastid and Diplonemid Mitochondrial Genomes. Methods Mol Biol. 2026;3013:133-152.
Faktorová D, Valach M, Iorillo O, Akiyoshi B, Burger G, Lukeš J. Genetic Manipulation of Paradiplonema papillatum. Methods Mol Biol. 2026;3014:3-25.
Valach M, Burger G, Faktorová D, Lukeš J, Škodová-Sveráková I. Biochemistry of Diplonemids. Methods Mol Biol. 2026;3014:225-248.
Tashyreva D, Prokopchuk G, Iorillo O, Valach M, Škodová-Sveráková I, Shin DW, Letts JA, Burger G, Lukeš J, Faktorová D. Isolation and Cultivation of Diplonemids. Methods Mol Biol. 2026;3013:25-40.
