Ramos H, Monette A, Niu M, Barrera A, López-Ulloa B, Fuentes Y, Guizar P, Pino K, DesGroseillers L, Mouland AJ, López-Lastra M. Correction to ‘The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation’. Nucleic Acids Res. 2021 Dec 15:gkab1266.
Bergeron-Sandoval LP, Kumar S, Heris HK, Chang CLA, Cornell CE, Keller SL, François P, Hendricks AG, Ehrlicher AJ, Pappu RV, Michnick SW. Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2113789118.
Ramos H, Monette A, Niu M, Barrera A, López-Ulloa B, Fuentes Y, Guizar P, Pino K, DesGroseillers L, Mouland AJ, López-Lastra M. The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation. Nucleic Acids Res. 2021 Dec 6:gkab1188.
Helness A, Fraszczak J, Joly-Beauparlant C, Bagci H, Trahan C, Arman K, Shooshtarizadeh P, Chen R, Ayoub M, Côté JF, Oeffinger M, Droit A, Möröy T. GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors. Commun Biol. 2021 Dec 2;4(1):1356.
Galipeau Y, Siragam V, Laroche G, Marion E, Greig M, McGuinty M, Booth RA, Durocher Y, Cuperlovic-Culf M, Bennett SAL, Crawley AM, Giguère PM, Cooper C, Langlois MA. Relative Ratios of Human Seasonal Coronavirus Antibodies Predict the Efficiency of Cross-Neutralization of SARS-CoV-2 Spike Binding to ACE2. EBioMedicine. 2021 Nov 29;74:103700.
Sverzhinsky A, Tomkinson AE, Pascal JM. Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Structure. 2021 Nov 22:S0969-2126(21)00414-7.
Langelier MF, Billur R, Sverzhinsky A, Black BE, Pascal JM. HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications. Nat Commun. 2021 Nov 18;12(1):6675.
Pereira PHS, Garcia CRS, Bouvier M. Identifying Plasmodium falciparum receptor activation using bioluminescence resonance energy transfer (BRET)-based biosensors in HEK293 cells. Methods Cell Biol. 2021;166:223-233.
Barrett RRG, Nash CDiennet M, Cotnoir-White D, Doyle C, Mader S, Thomson AA, Gleason JL. Dual-function antiandrogen/HDACi hybrids based on enzalutamide and entinostat. Dual-function antiandrogen/HDACi hybrids based on enzalutamide and entinostat. Bioorg Med Chem Lett. 2021 Nov 9:128441.
Maluchenko NV, Nilov DK, Pushkarev SV, Kotova EY, Gerasimova NS, Kirpichnikov MP, Langelier MF, Pascal JM, Akhtar MS, Feofanov AV, Studitsky VM. Mechanisms of Nucleosome Reorganization by PARP1. Int J Mol Sci. 2021 Nov 9;22(22):12127.
Akache B, Renner TM, Tran A, Deschatelets L, Dudani R, Harrison BA, Duque D, Haukenfrers J, Rossotti MA, Gaudreault F, Hemraz UD, Lam E, Régnier S, Chen W, Gervais C, Stuible M, Krishnan L, Durocher Y, McCluskie MJ. Positivgenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant. Sci Rep. 2021 Nov 8;11(1):21849.
Duarte DA, Parreiras-E-Silva LT, Oliveira EB, Bouvier M, Costa-Neto CM. Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time. Hypertension. 2021 Nov 5:HYPERTENSIONAHA12117977. doi: 10.1161/HYPERTENSIONAHA.121.17977.
Hauser AS, Kooistra AJ, Munk C, Heydenreich FM, Veprintsev DB, Bouvier M, Babu MM, Gloriam DE. GPCR activation mechanisms across classes and macro/microscales. Nat Struct Mol Biol. 2021 Nov;28(11):879-888.
Porras L, Ismail H, Mader S. Positive Regulation of Estrogen Receptor Alpha in Breast Tumorigenesis. Cells. 2021 Oct 31;10(11):2966.
Dagenais P, Desjardins G, Legault P. An integrative NMR-SAXS approach for structural determination of large RNAs defines the substrate-free state of a trans-cleaving Neurospora Varkud Satellite ribozyme. Nucleic Acids Res. 2021 Oct 28:gkab963.
Del Toro N, Lessard F, Bouchard J, Mobasheri N, Guillon J, Igelmann S, Tardif S, Buffard T, Bourdeau V, Brakier-Gingras L, Ferbeyre G. Cellular Senescence limits Translational Readthrough. Biol Open. 2021 Oct 22:bio.058688.
Mehdizadeh M, Aguilar M, Thorin E, Ferbeyre G, Nattel S. The role of cellular senescence in cardiac disease: basic biology and clinical relevance. Nat Rev Cardiol. 2021 Oct 19. doi: 10.1038/s41569-021-00624-2.
Tani I, Ito S, Shirahata Y, Matsuyama Y, Omichinski JG, Shimohigashi Y, Kamada R, Sakaguchi K. Role of active site arginine residues in substrate recognition by PPM1A. Biochem Biophys Res Commun. 2021 Oct 6;581:1-5.
Arinjay Banerjee, Karen Mossman, Nathalie Grandvaux. Molecular Determinants of SARS-CoV-2 Variants. Trends Microbiol. 2021 Oct;29(10):871-873.
Ehrlich AT, Semache M, Couvineau P, Wojcik S, Kobayashi H, Thelen M, Gross F, Hogue M, Le Gouill C, Darcq E, Bouvier M, Kieffer BL. Ackr3-Venus knock-in mouse lights up brain vasculature. Mol Brain. 2021 Sep 28;14(1):151.
Igelmann S, Lessard F, Uchenunu O, Bouchard J, Fernandez-Ruiz A, Rowell MC, Lopes-Paciencia S, Papadopoli D, Fouillen A, Ponce KJ, Huot G, Mignacca L, Benfdil M, Kalegari P, Wahba HM, Pencik J, Vuong N, Quenneville J, Guillon J, Bourdeau V, Hulea L, Gagnon E, Kenner L, Moriggl R, Nanci A, Pollak MN, Omichinski JG, Topisirovic I, Ferbeyre G. A hydride transfer complex reprograms NAD metabolism and bypasses senescence. Mol Cell. 2021 Sep 16;81(18):3848-3865.
Budzinski J, Maschauer S, Kobayashi H, Couvineau P, Vogt H, Gmeiner P, Roggenhofer A, Prante O, Bouvier M, Weikert D. Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer. Commun Biol. 2021 Sep 10;4(1):1062.
Mansour A, Nagi K, Dallaire P, Lukasheva V, Le Gouill C, Bouvier M, Pineyro G. Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation. ACS Pharmacol Transl Sci. 2021 Sep 9;4(5):1483-1498.
Markmiller S, Sathe S, Server KL, Nguyen TB, Fulzele A, Cody N, Javaherian A, Broski S, Finkbeiner S, Bennett EJ, Lécuyer E, Yeo GW. Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress. Cell Rep. 2021 Sep 7;36(10):109685.
Simon Grandjean Lapierre, Stéphane Bedwani, François DeBlois, Audray Fortin, Natalia Zamorano Cuervo, Karim Zerouali, Elise Caron, Philippe Morency-Potvin, Simon Gagnon, Nakome Nguissan, Pascale Arlotto, Isabelle Hardy, Catherine-Audrey Boutin, Cécile Tremblay, François Coutlée, Jacques de Guise, Nathalie Grandvaux. Clinical Evaluation of In-House-Produced 3D-Printed Nasopharyngeal Swabs for COVID-19 Testing. Viruses. 2021 Sep 2;13(9):1752.
Hegron A, Huh E, Deupi X, Sokrat B, Gao W, Le Gouill C, Canouil M, Boissel M, Charpentier G, Roussel R, Balkau B, Froguel P, Plouffe B, Bonnefond A, Lichtarge O, Jockers R, Bouvier M. Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants. ACS Pharmacol Transl Sci. 2021 Sep 1;4(5):1614-1627.
García RA, Lupisella JA, Ito BR, Hsu MY, Fernando G, Carson NL, Allocco JJ, Ryan CS, Zhang R, Wang Z, Heroux M, Carrier M, St-Onge S, Bouvier M, Dudhgaonkar S, Nagar J, Bustamante-Pozo MM, Garate-Carrillo A, Chen J, Ma X, Search DJ, Dierks EA, Kick EK, Wexler RR, Gordon DA, Ostrowski J, Wurtz NR, Villarreal F. Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction. JACC Basic Transl Sci. 2021 Aug 23;6(8):676-689.
Dodat F, Mader S, Lévesque D. Minireview: what is known about SUMOylation among NR4A family members? J Mol Biol. 2021 Aug 23:167212.
Sun Y, Chen J, Huang SN, Su YP, Wang W, Agama K, Saha S, Jenkins LM, Pascal JM, Pommier Y. PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation. Nat Commun. 2021 Aug 18;12(1):5010.
Giubilaro J, Schuetz DA, Stepniewski TM, Namkung Y, Khoury E, Lara-Márquez M, Campbell S, Beautrait A, Armando S, Radresa O, Duchaine J, Lamarche-Vane N, Claing A, Selent J, Bouvier M, Marinier A, Laporte SA. Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen. Nat Commun. 2021 Aug 3;12(1):4688.
Arinjay Banerjee, Karen Mossman, Nathalie Grandvaux. Molecular Determinants of SARS-CoV-2 Variants. Trends Microbiol. 2021 Jul 27;S0966-842X(21)00162-1.
Barazetti JF, Jucoski TS, Carvalho TM, Veiga RN, Kohler AF, Baig J, Al Bizri H, Gradia DF, Mader S, Carvalho de Oliveira J. From Micro to Long: Non-Coding RNAs in Tamoxifen Resistance of Breast Cancer Cells. Cancers (Basel). 2021 Jul 22;13(15):3688.
Pelletier A, Mayran A, Gouhier A, Omichinski JG, Balsalobre A, Drouin J. Pax7 pioneer factor action requires both paired and homeo DNA binding domains. Nucleic Acids Res. 2021 Jul 21;49(13):7424-7436.
Marie-Eve Dubuis, Étienne Racine, Jonathan M Vyskocil, Nathalie Turgeon, Christophe Tremblay, Espérance Mukawera, Guy Boivin, Nathalie Grandvaux, Caroline Duchaine. Ozone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes. PLoS One. 2021 Jul 12;16(7):e0253022.
Djaileb A, Hojjat Jodaylami M, Coutu J, Ricard P, Lamarre M, Rochet L, Cellier-Goetghebeur S, Macaulay D, Charron B, Lavallée É, Thibault V, Stevenson K, Forest S, Live LS, Abonnenc N, Guedon A, Quessy P, Lemay JF, Farnós O, Kamen A, Stuible M, Gervais C, Durocher Y, Cholette F, Mesa C, Kim J, Cayer MP, de Grandmont MJ, Brouard D, Trottier S, Boudreau D, Pelletier JN, Masson JF. Cross-validation of ELISA and a portable surface plasmon resonance instrument for IgG antibody serology with SARS-CoV-2 positive individuals. Analyst. 2021 Jul 12. doi: 10.1039/d1an00893e.
Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu F. Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs. Cell Res. 2021 Jul 8. doi: 10.1038/s41422-021-00525-6.
Stepniewski TM, Mancini A, Ågren R, Torrens-Fontanals M, Semache M, Bouvier M, Sahlholm K, Breton B, Selent J. Mechanistic insights into dopaminergic and serotonergic neurotransmission – concerted interactions with helices 5 and 6 drive the functional outcome. Chem Sci. 2021 Jul 2;12(33):10990-11003.
Pelletier A, Mayran A, Gouhier A, Omichinski JG, Balsalobre A, Drouin J. Pax7 pioneer factor action requires both paired and homeo DNA binding domains. Nucleic Acids Res. 2021 Jul 1:gkab561.
Rashid I, Hammel M, Sverzhinsky A, Tsai MS, Pascal JM, Tainer JA, Tomkinson AE. Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus. J Biol Chem. 2021 Jun 25:100921.
Kobayashi H, Bouvier M. Bioluminescence Resonance Energy Transfer (BRET) Imaging in Living Cells: Image Acquisition and Quantification. Methods Mol Biol. 2021;2274:305-314.
Fellouse FA, Miersch S, Chen C, Michnick SW. Structure-based Design of a Specific, Homogeneous Luminescence Enzyme Reporter Assay for SARS-CoV-2. J Mol Biol. 2021 Jun 25;433(13):166983.
Forest-Nault C, Gaudreault J, Henry O, Durocher Y, De Crescenzo G. On the Use of Surface Plasmon Resonance Biosensing to Understand IgG-FcγR Interactions. Int J Mol Sci. 2021 Jun 21;22(12):6616.
N’Guessan A, Brito IL, Serohijos AWR, Shapiro BJ. Mobile gene sequence evolution within individual human gut microbiomes is better explained by gene-specific than host-specific selective pressures. Genome Biol Evol. 2021 Jun 16:evab142.
Razban RM, Dasmeh P, Serohijos AWR, Shakhnovich EI. Avoidance of protein unfolding constrains protein stability in long-term evolution. Biophys J. 2021 Jun 15;120(12):2413-2424.
Trauelsen M, Hiron TK, Lin D, Petersen JE, Breton B, Husted AS, Hjorth SA, Inoue A, Frimurer TM, Bouvier M, O’Callaghan CA, Schwartz TW. Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling. Cell Rep. 2021 Jun 15;35(11):109246.
Sidibé H, Khalfallah Y, Xiao S, Gómez NB, Fakim H, Tank EMH, Tomasso GD, Bareke E, Aulas A, McKeever PM, Melamed Z, Destroimaisons L, Deshaies JE, Zinman L, Parker JA, Legault P, Tétreault M, Barmada SJ, Robertson J, Velde CV. TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia. Brain. 2021 Jun 11:awab217.
Mancini OK, Acevedo M, Fazez N, Cuillerier A, Ruiz AF, Huynh DN, Burelle Y, Ferbeyre G, Baron M, Servant MJ. Oxidative stress-induced senescence mediates inflammatory and fibrotic phenotypes in fibroblasts from systemic sclerosis patients. Rheumatology (Oxford). 2021 Jun 11:keab477.
Larouche M, Kachaner D, Wang P, Normandin K, Garrido D, Yao C, Cormier M, Johansen KM, Johansen J, Archambault V. Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression. J Cell Biol. 2021 Jun 7;220(6):e202008145.
Henry KA, Nguyen TD, Baral TN, Hussack G, Raphael S, Arbabi-Ghahroudi M, Robert A, Durocher Y, Wu C, Jaramillo ML, MacKenzie CR. Biparatopic single-domain antibodies against Axl achieve ultra-high affinity through intramolecular engagement. Biochem Biophys Res Commun. 2021 May 28;562:154-161.
Wright SC, Bouvier M. Illuminating the complexity of GPCR pathway selectivity – advances in biosensor development. Curr Opin Struct Biol. 2021 May 25;69:142-149.
Bonnet-Magnaval F, DesGroseillers L. The Staufen1-dependent cell cycle regulon or how a misregulated RNA-binding protein leads to cancer. Biol Rev Camb Philos Soc. 2021 May 20. doi: 10.1111/brv.12749.
Karine Tremblay, Simon Rousseau, Ma’n H Zawati, Daniel Auld, Michaël Chassé, Daniel Coderre, Emilia Liana Falcone, Nicolas Gauthier, Nathalie Grandvaux, François Gros-Louis, Carole Jabet, Yann Joly, Daniel E Kaufmann, Catherine Laprise, Catherine Larochelle, François Maltais, Anne-Marie Mes-Masson, Alexandre Montpetit, Alain Piché, J Brent Richards, Sze Man Tse, Alexis F Turgeon, Gustavo Turecki, Donald C Vinh, Han Ting Wang, Vincent Mooser, BQC19. The Biobanque québécoise de la COVID-19 (BQC19)—A cohort to prospectively study the clinical and biological determinants of COVID-19 clinical trajectories. PLoS One. 2021 May 19;16(5):e0245031.
Wright SC, Lukasheva V, Le Gouill C, Kobayashi H, Breton B, Mailhot-Larouche S, Blondel-Tepaz É, Antunes Vieira N, Costa-Neto C, Héroux M, Lambert NA, Parreiras-E-Silva LT, Bouvier M. BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gq activation at early endosomes. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2025846118.
Hébert A, Parisotto M, Rowell MC, Doré A, Fernandez Ruiz A, Lefrançois G, Kalegari P, Ferbeyre G, Schmitzer AR. Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth. Sci Rep. 2021 May 10;11(1):9854.
Bensidoun P, Zenklusen D, Oeffinger M. Choosing the right exit: How functional plasticity of the nuclear pore drives selective and efficient mRNA export. Wiley Interdiscip Rev RNA. 2021 May 2:e1660.
Beauséjour M, Vaillancourt F, Akoume MY, Franco A, Parent S, Labelle H, Joncas J, Desbiens-Blais F, Mac-Thiong JM, Roy-Beaudry M, Aubin CÉ, Moreau A. Patient outcomes in idiopathic scoliosis are associated with biological endophenotypes: 2020 SOSORT award winner. Eur Spine J. 2021 May;30(5):1125-1131.
Razban RM, Dasmeh P, Serohijos AWR, Shakhnovich EI. Avoidance of protein unfolding constrains protein stability in long-term evolution. Biophys J. 2021 Apr 28:S0006-3495(21)00340-4.
Natalia Zamorano Cuervo, Audray Fortin, Elise Caron, Stéfany Chartier, Nathalie Grandvaux. Pinpointing cysteine oxidation sites by high-resolution proteomics reveals a mechanism of redox-dependent inhibition of human STING. Sci Signal. 2021 Apr 27;14(680):eaaw4673.
de Melo Teixeira M, Lang BF, Matute DR, Stajich JE, Barker B. The mitochondrial genomes of the human pathogens Coccidioides immitis and C. posadasii. G3 (Bethesda). 2021 Apr 19:jkab132.
Fellouse FA, Miersch S, Chen C, Michnick SW. Structure-Based Design of a Specific, Homogeneous Luminescence Enzyme Reporter Assay for SARS-CoV-2. J Mol Biol. 2021 Apr 8:166983. doi: 10.1016/j.jmb.2021.166983.
Liu X, Chai Y, Liu G, Su W, Guo Q, Lv X, Gao P, Yu B, Ferbeyre G, Cao X, Wan M. Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis. Nat Commun. 2021 Mar 23;12(1):1832.
Brouwers B, de Oliveira EM, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, Henning E, Bounds R, Daly CA, Houston S, Ayinampudi V, Wasiluk N, Clarke D, Plouffe B, Bouvier M, Babu MM, Farooqi IS, Mokrosiński J. Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation. Cell Rep. 2021 Mar 23;34(12):108862.
Meyrath M, Palmer CB, Reynders N, Vanderplasschen A, Ollert M, Bouvier M, Szpakowska M, Chevigné A. Proadrenomedullin N-Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7. ACS Pharmacol Transl Sci. 2021 Mar 22;4(2):813-823.
Leguay K, Decelle B, He YY, Pagniez A, Hogue M, Kobayashi H, Le Gouill C, Bouvier M, Carréno S. Development of conformational BRET biosensors that monitor ezrin, radixin and moesin activation in real-time. J Cell Sci. 2021 Mar 12:jcs.255307.
Valach M, Gonzalez Alcazar JA, Sarrasin M, Lang BF, Gray MW, Burger G. An Unexpectedly Complex Mitoribosome in Andalucia godoyi, a Protist with the Most Bacteria-like Mitochondrial Genome. Mol Biol Evol. 2021 Mar 9;38(3):788-804.
Grunddal KV, Diep TA, Petersen N, Tough IR, Skov LJ, Liu L, Buijink JA, Mende F, Jin C, Jepsen SL, Sørensen LME, Achiam MP, Strandby RB, Bach A, Hartmann B, Frimurer TM, Hjorth SA, Bouvier M, Cox H, Holst B. Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist. Mol Metab. 2021 Mar 9:101207.
Gargalovic P, Wong P, Onorato J, Finlay H, Wang T, Yan M, Crain E, St-Onge S, Héroux M, Bouvier M, Xu C, Chen XQ, Generaux C, Lawrence M, Wexler R, Gordon D. In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure. Circ Heart Fail. 2021 Mar 5:CIRCHEARTFAILURE120007351.
Condé L, Gonzalez Quesada Y, Bonnet-Magnaval F, Beaujois R, DesGroseillers L. STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells. BMC Mol Cell Biol. 2021 Mar 4;22(1):16.
Fabre L, Ntreh AT, Yazidi A, Leus IV, Weeks JW, Bhattacharyya S, Ruickoldt J, Rouiller I, Zgurskaya HI, Sygusch J. A « Drug Sweeping » State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa. Structure. 2021 Mar 4;29(3):261-274.
Bury M, Le Calvé B, Ferbeyre G, Blank V, Lessard F. New Insights into CDK Regulators: Novel Opportunities for Cancer Therapy. Trends Cell Biol. 2021 Mar 3:S0962-8924(21)00025-8.
Blondel-Tepaz E, Leverve M, Sokrat B, Paradis JS, Kosic M, Saha K, Auffray C, Lima-Fernandes E, Zamborlini A, Poupon A, Gaboury L, Findlay J, Baillie GS, Enslen H, Bouvier M, Angers S, Marullo S, Scott MGH. The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis. Oncogene. 2021 Mar 1. doi: 10.1038/s41388-021-01704-w.
Knüppel R, Trahan C, Kern M, Wagner A, Grünberger F, Hausner W, Quax TEF, Albers SV, Oeffinger M, Ferreira-Cerca S. Insights into synthesis and function of KsgA/Dim1-dependent rRNA modifications in archaea. Nucleic Acids Res. 2021 Feb 22;49(3):1662-1687.
Genois MM, Gagné JP, Yasuhara T, Jackson J, Saxena S, Langelier MF, Ahel I, Bedford MT, Pascal JM, Vindigni A, Poirier GG, Zou L. CARM1 regulates replication fork speed and stress response by stimulating PARP1. Mol Cell. 2021 Feb 18;81(4):784-800.e8.
Gaudreault J, Liberelle B, Durocher Y, Henry O, De Crescenzo G. Determination of the composition of heterogeneous binder solutions by surface plasmon resonance biosensing. Sci Rep. 2021 Feb 11;11(1):3685.
Jayabalan AK, Adivarahan S, Koppula A, Abraham R, Batish M, Zenklusen D, Griffin DE, Leung AKL. Stress granule formation, disassembly, and composition are regulated by alphavirus ADP-ribosylhydrolase activity. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2021719118.
Tschaikner P, Regele D, Röck R, Salvenmoser W, Meyer D, Bouvier M, Geley S, Stefan E, Aanstad P. Feedback Control of the Gpr161-Gαs-PKA axis contributes to basal Hedgehog repression in zebrafish. Development. 2021 Feb 2:dev.192443.
Trân K, Van Den Hauwe R, Sainsily X, Couvineau P, Côté J, Simard L, Echevarria M, Murza A, Serre A, Théroux L, Saibi S, Haroune L, Longpré JM, Lesur O, Auger-Messier M, Spino C, Bouvier M, Sarret P, Ballet S, Marsault É. Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile. J Med Chem. 2021 Feb 1. doi: 10.1021/acs.jmedchem.0c01941.
Dodat F, Cotnoir-White D, Dianati E, Vallet A, Mader S, Lévesque D. Complex regulation of orphan nuclear receptor Nur77 (Nr4a1) transcriptional activity by SUMO2 and PIASγ. Biochim Biophys Acta Mol Cell Res. 2021 Feb;1868(2):118908.
Ogden TEH, Yang JC, Schimpl M, Easton LE, Underwood E, Rawlins PB, McCauley MM, Langelier MF, Pascal JM, Embrey KJ, Neuhaus D. Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition. Nucleic Acids Res. 2021 Jan 28:gkab020.
Stuible M, Gervais C, Lord-Dufour S, Perret S, L’Abbé D, Schrag J, St-Laurent G, Durocher Y. Rapid, high-yield production of full-length SARS-CoV-2 spike ectodomain by transient gene expression in CHO cells. J Biotechnol. 2021 Jan 20;326:21-27.
Corrêa MF, Balico-Silva AL, Kiss DJ, Fernandes GAB, Maraschin JC, Parreiras-E-Silva LT, Varela MT, Simões SC, Bouvier M, Keserű GM, Costa-Neto CM, Fernandes JPS. Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands – Functional characterization and modeling studies on H3 and H4 receptors. Bioorg Med Chem. 2021 Jan 15;30:115924.
Trân K, Murza A, Sainsily X, Delile E, Couvineau P, Côté J, Coquerel D, Peloquin M, Auger-Messier M, Bouvier M, Lesur O, Sarret P, Marsault É. Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor. J Med Chem. 2021 Jan 14;64(1):602-615.
Knüppel R, Trahan C, Kern M, Wagner A, Grünberger F, Hausner W, Quax TEF, Albers SV, Oeffinger M, Ferreira-Cerca S. Insights into synthesis and function of KsgA/Dim1-dependent rRNA modifications in archaea. Nucleic Acids Res. 2021 Jan 12:gkaa1268.
Hammel M, Rashid I, Sverzhinsky A, Pourfarjam Y, Tsai MS, Ellenberger T, Pascal JM, Kim IK, Tainer JA, Tomkinson AE. An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex. Nucleic Acids Res. 2021 Jan 11;49(1):306-321.
René P, Lanfray D, Richard D, Bouvier M. Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity. JCI Insight. 2021 Jan 12:132778.
Van Nostrand EL, Freese P, Pratt GA, Wang X, Wei X, Xiao R, Blue SM, Chen JY, Cody NAL, Dominguez D, Olson S, Sundararaman B, Zhan L, Bazile C, Bouvrette LPB, Bergalet J, Duff MO, Garcia KE, Gelboin-Burkhart C, Hochman M, Lambert NJ, Li H, McGurk MP, Nguyen TB, Palden T, Rabano I, Sathe S, Stanton R, Su A, Wang R, Yee BA, Zhou B, Louie AL, Aigner S, Fu XD, Lécuyer E, Burge CB, Graveley BR, Yeo GW. A large-scale binding and functional map of human RNA-binding proteins. Nature. 2021 Jan 5. doi: 10.1038/s41586-020-03067-w.
Adivarahan S, Zenklusen D. Probing the Conformational State of mRNPs Using smFISH and SIM. Methods Mol Biol. 2021; 2209:267-286.
Dagenais P, Legault P. In Vitro Selection of Varkud Satellite Ribozyme Variants that Cleave a Modified Stem-Loop Substrate. Methods Mol Biol. 2021;2167:61-77.
Chin A, Lécuyer E. Puromycin Labeling Coupled with Proximity Ligation Assays to Define Sites of mRNA Translation in Drosophila Embryos and Human Cells. Methods Mol Biol. 2021;2381:267-284.
Lenferink AEG, McDonald PC, Cantin C, Grothé S, Gosselin M, Baardsnes J, Banville M, Lachance P, Robert A, Cepero-Donates Y, Radinovic S, Salois P, Parat M, Oamari H, Dulude A, Patel M, Lafrance M, Acel A, Bousquet-Gagnon N, L’Abbé D, Pelletier A, Malenfant F, Jaramillo M, O’Connor-Mccourt M, Wu C, Durocher Y, Duchesne M, Gadoury C, Marcil A, Fortin Y, Paul-Roc B, Acchione M, Chafe SC, Nemirovsky O, Lau J, Bénard F, Dedhar S. Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX. MAbs. 2021 Jan-Dec;13(1):1999194.