Publications 2024

Stocks BB, Thibeault MP, L’Abbé D, Umer M, Liu Y, Stuible M, Durocher Y, Melanson JE. Characterization of biotinylated human ACE2 and SARS-CoV-2 Omicron BA.4/5 spike protein reference materials. Anal Bioanal Chem. 2024 Jun 28.

Ravindran R, Michnick SW. Biomolecular condensates as drivers of membrane trafficking and remodelling. Curr Opin Cell Biol. 2024 Jun 26;89:102393.

Jasinska W, Dindo M, Cordoba SMC, Serohijos AWR, Laurino P, Brotman Y, Bershtein S. Non-consecutive enzyme interactions within TCA cycle supramolecular assembly regulate carbon-nitrogen metabolism. Nat Commun. 2024 Jun 20;15(1):5285.

Wright SC, Avet C, Gaitonde SA, Muneta-Arrate I, Le Gouill C, Hogue M, Breton B, Koutsilieri S, Alarcia RD, Héroux M, Lauschke VM, Bouvier M. Conformation- and activation-based BRET sensors differentially report on GPCR-G protein coupling. Sci Signal. 2024 Jun 18;17(841):eadi4747.

Bettin N, Querido E, Gialdini I, Grupelli GP, Goretti E, Cantarelli M, Andolfato M, Soror E, Sontacchi A, Jurikova K, Chartrand P, Cusanelli E. TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends. Sci Adv. 2024 Jun 14;10(24):eadk4387.

Ives CM, Nguyen L, Fogarty CA, Harbison AM, Durocher Y, Klassen J, Fadda E. Role of N343 glycosylation on the SARS-CoV-2 S RBD structure and co-receptor binding across variants of concern. Elife. 2024 Jun 12;13:RP95708.

Morin C, Verma VT, Arya T, Casu B, Jolicoeur E, Ruel R, Marinier A, Sygusch J, Baron C. Structure-based design of small molecule inhibitors of the cagT4SS ATPase Cagα of Helicobacter pylori. Biochem Cell Biol. 2024 Jun 1;102(3):226-237.

Kossatz E, Diez-Alarcia R, Gaitonde SA, Ramon-Duaso C, Stepniewski TM, Aranda-Garcia D, Muneta-Arrate I, Tepaz E, Saen-Oon S, Soliva R, Shahraki A, Moreira D, Brea J, Loza MI, de la Torre R, Kolb P, Bouvier M, Meana JJ, Robledo P, Selent J. G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits. Nat Commun. 2024 May 29;15(1):4307.

Wang Y, Sauvage M, Diennet M, Weber S, Mader S, Gleason JL. Design, synthesis and antiproliferative activity of raloxifene/histone deacetylase inhibitor hybrids in breast cancer. Eur J Med Chem. 2024 May 24;274:116533.

El Bakkouri Y, Chidiac R, Delisle C, Corriveau J, Cagnone G, Gaonac’h-Lovejoy V, Chin A, Lécuyer É, Angers S, Joyal JS, Topisirovic I, Hulea L, Dubrac A, Gratton JP. ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis. Nat Commun. 2024 May 23;15(1):4405.

Smith-Pillet ES, Billur R, Langelier MF, Talele TT, Pascal JM, Black BE. A PARP2-specific active site α-helix melts to permit DNA damage-induced enzymatic activation. bioRxiv [Preprint]. 2024 May 20:2024.05.20.594972.

Shkreta L, Toutant J, Delannoy A, Durantel D, Salvetti A, Ehresmann S, Sauvageau M, Delbrouck JA, Gravel-Trudeau A, Comeau C, Huard C, Coulombe-Huntington J, Tyers M, Grierson D, Boudreault PL, Chabot B. The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response. Oncotarget. 2024 May 16;15:313-325.

Laliberté C, Bossé B, Bourdeau V, Prieto LI, Perron-Deshaies G, Vuong-Robillard N, Igelmann S, Aguilar LC, Oeffinger M, Baker DJ, DesGroseillers L, Ferbeyre G. Senescent Macrophages Release Inflammatory Cytokines and RNA-Loaded Extracellular Vesicles to Circumvent Fibroblast Senescence. Biomedicines. 2024 May 14;12(5):1089.

Ali MG, Wahba HM, Igelmann S, Cyr N, Ferbeyre G, Omichinski JG. Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR. Autophagy. 2024 May 10. doi: 10.1080/15548627.2024.2353443.

Reyes SJ, Lemire L, Molina RS, Roy M, L’Ecuyer-Coelho H, Martynova Y, Cass B, Voyer R, Durocher Y, Henry O, Pham PL. Multivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary cell pools expressing SARS-CoV-2 spike protein as vaccine antigen in early process development. Biotechnol Prog. 2024 Apr 25:e3467.

Larouche JD, Laumont CM, Trofimov A, Vincent K, Hesnard L, Brochu S, Côté C, Humeau JF, Bonneil É, Lanoix J, Durette C, Gendron P, Laverdure JP, Richie ER, Lemieux S, Thibault P, Perreault C. Transposable elements regulate thymus development and function. Elife. 2024 Apr 18;12:RP91037.

Lamontagne F, Paz Trejo C, Zamorano Cuervo N, Grandvaux N. Redox signaling in cell fate: Beyond damage. Biochim Biophys Acta Mol Cell Res. 2024 Apr 12:119722.

Coulombe B, Durcan TM, Bernard G, Moursli A, Poitras C, Faubert D, Pinard M. The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases. Mol Brain. 2024 Apr 11;17(1):18.

Normand É, Franco A, Parent S, Lombardi G, Brayda-Bruno M, Colombini A, Moreau A, Marcil V. Association between the GLP1R A316T Mutation and Adolescent Idiopathic Scoliosis in French Canadian and Italian Cohorts. Genes (Basel). 2024 Apr 11;15(4):481.

Pschunder B, Locati L, López O, Martin Aispuro P, Zurita E, Stuible M, Durocher Y, Hozbor D. Outer membrane vesicles derived from Bordetella pertussis are potent adjuvant that drive Th1-biased response. Front Immunol. 2024 Apr 8;15:1387534.

Gaitonde SA, Avet C, de la Fuente Revenga M, Blondel-Tepaz E, Shahraki A, Pastor AM, Talagayev V, Robledo P, Kolb P, Selent J, González-Maeso J, Bouvier M. Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor. Mol Psychiatry. 2024 Apr 2. doi: 10.1038/s41380-024-02531-7.

Lopes-Paciencia S, Bourdeau V, Rowell MC, Amirimehr D, Guillon J, Kalegari P, Barua A, Quoc-Huy Trinh V, Azzi F, Turcotte S, Serohijos A, Ferbeyre G. A senescence restriction point acting on chromatin integrates oncogenic signals. Cell Rep. 2024 Apr 2;43(4):114044.

Agbayani G, Akache B, Renner TM, Tran A, Stuible M, Dudani R, Harrison BA, Duque D, Bavananthasivam J, Deschatelets L, Hemraz UD, Régnier S, Durocher Y, McCluskie MJ. Intranasal administration of unadjuvanted SARS-CoV-2 spike antigen boosts antigen-specific immune responses induced by parenteral protein subunit vaccine prime in mice and hamsters. Eur J Immunol. 2024 Apr 1:e2350620.

Petraccione K, Ali MGH, Cyr N, Wahba HM, Stocker T, Akhrymuk M, Akhrymuk I, Panny L, Bracci N, Cafaro R, Sastre D, Silberfarb A, O’Maille P, Omichinski J, Kehn-Hall K. An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy. PLoS Pathog. 2024 Mar 21;20(3):e1012093.

Velagapudi UK, Rouleau-Turcotte É, Billur R, Shao X, Patil M, Black BE, Pascal JM, Talele TT. Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks. Biochem J. 2024 Mar 20;481(6):437-460.

Chofflet N, Naito Y, Pastore AJ, Padmanabhan N, Nguyen PT, Poitras C, Feller B, Yi N, Van Prooijen J, Khaled H, Coulombe B, Clapcote SJ, Bourgault S, Siddiqui TJ, Rudenko G, Takahashi H. Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization. Front Mol Neurosci. 2024 Mar 20;17:1371145.

Sanchez-Martinez ZV, Alpuche-Lazcano SP, Stuible M, Durocher Y. CHO cells for virus-like particle and subunit vaccine manufacturing. Vaccine. 2024 Mar 18:S0264-410X(24)00321-9.

Masclef L, Ahmed O, Iannantuono N, Gagnon J, Gushul-Leclaire M, Boulay K, Estavoyer B, Echbicheb M, Poy M, Boubacar KA, Boubekeur A, Menggad S, Schcolnik-Cabrera A, Balsalobre A, Bonneil E, Thibault P, Hulea L, Tanaka Y, Antoine-Mallette F, Drouin J, Affar EB. O-GlcNAcylation of FOXK1 orchestrates the E2F pathway and promotes oncogenesis. bioRxiv [Preprint]. 2024 Mar 1:2024.03.01.582838.

Gross F, Mancini A, Breton B, Kobayashi H, Pereira PHS, Le Gouill C, Bouvier M, Schann S, Leroy X, Sabbagh L. EGFR signaling and pharmacology in oncology revealed with innovative BRET-based biosensors. Commun Biol. 2024 Mar 1;7(1):250.

Morin C, Verma VT, Arya T, Casu B, Jolicoeur E, Ruel R, Marinier A, Sygusch J, Baron C. Structure-based design of small molecule inhibitors of the cagT4SS ATPase Cagα of Helicobacter pylori. Biochem Cell Biol. 2024 Feb 20. doi: 10.1139/bcb-2023-0331.

Gaudreault J, Forest-Nault C, Gilbert M, Durocher Y, Henry O, De Crescenzo G. A low-temperature SPR-based assay for monoclonal antibody galactosylation and fucosylation assessment using FcγRIIA/B. Biotechnol Bioeng. 2024 Feb 14. doi: 10.1002/bit.28673.

Thimmappa BC, Salhi LN, Forget L, Sarrasin M, Bustamante Villalobos P, Henrissat B, Lang BF, Burger G. A biofertilizing fungal endophyte of cranberry plants suppresses the plant pathogen Diaporthe. Front Microbiol. 2024 Feb 2;15:1327392.

Chol A, Sarrazin-Gendron R, Lécuyer É, Blanchette M, Waldispühl J. PERFUMES: Pipeline to extract RNA FUnctional motifs and exposed structures. Bioinformatics. 2024 Jan 30:btae056.

Gutierrez-Camino A, Caron M, Richer C, Fuchs C, Illarregi U, Poncelet L, St-Onge P, Bataille AR, Tremblay-Dauphinais P, Lopez-Lopez E, Camos M, Ramirez-Orellana M, Astigarraga I, Lécuyer É, Bourque G, Martin-Guerrero I, Sinnett D. CircRNAome of Childhood Acute Lymphoblastic Leukemia: Deciphering Subtype-Specific Expression Profiles and Involvement in TCF3::PBX1 ALL. Int J Mol Sci. 2024 Jan 25;25(3):1477.

Dadhwal G, Samy H, Bouvette J, El-Azzouzi F, Dagenais P, Legault P. Substrate promiscuity of Dicer toward precursors of the let-7 family and their 3′-end modifications. Cell Mol Life Sci. 2024 Jan 23;81(1):53.

Luo H, Lao L, Au KS, Northrup H, He X, Forget D, Gauthier MS, Coulombe B, Bourdeau I, Shi W, Gagliardi L, Fragoso MCBV, Peng J, Wu J. ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans. Genome Biol. 2024 Jan 15;25(1):19.

Seif E, Francis NJ. A Two-Step Mechanism for Creating Stable, Condensed Chromatin with the Polycomb Complex PRC1. Molecules. 2024 Jan 9;29(2):323.

Mehdizadeh M, Naud P, Abu-Taha IH, Hiram R, Xiong F, Xiao J, Saljic A, Kamler M, Vuong-Robillard N, Thorin E, Ferbeyre G, Tardif JC, Sirois MG, Tanguay JF, Dobrev D, Nattel S. The role of cellular senescence in profibrillatory atrial remodeling associated with cardiac pathology. Cardiovasc Res. 2024 Jan 5:cvae003.

Gouhier A, Dumoulin-Gagnon J, Lapointe-Roberge V, Harris J, Balsalobre A, Drouin J. Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening. Nat Struct Mol Biol. 2024 Jan 4. doi: 10.1038/s41594-023-01152-y.

Sachan V, Le Dévéhat M, Roubtsova A, Essalmani R, Laurendeau JF, Garçon D, Susan-Resiga D, Duval S, Mikaeeli S, Hamelin J, Evagelidis A, Chong M, Paré G, Chernetsova E, Gao ZH, Robillard I, Ruiz M, Trinh VQ, Estall JL, Faraj M, Austin RC, Sauvageau M, Prat A, Kiss RS, Seidah NG. PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease. Metabolism. 2024 Jan;150:155736.

Pinard M, Moursli A, Coulombe B. Drugs targeting the particle for arrangement of quaternary structure (PAQosome) and protein complex assembly. Expert Opin Drug Discov. 2024 Jan-Jun;19(1):57-71.

Forest-Nault C, Koyuturk I, Gaudreault J, Pelletier A, L’Abbé D, Cass B, Bisson L, Burlacu A, Delafosse L, Stuible M, Henry O, De Crescenzo G, Durocher Y. A Biosensor Assay Based on Coiled-Coil-Mediated Human ACE2 Receptor Capture for the Analysis of Its Interactions with the SARS-CoV-2 Receptor Binding Domain. Methods Mol Biol. 2024;2762:89-105.

Delafosse L, Lord-Dufour S, Pelletier A, Perret S, Burlacu A, Ouimet M, Cass B, Joubert S, Stuible M, Durocher Y. Recombinant Protein Production from Stable CHO Cell Pools. Methods Mol Biol. 2024;2810:99-121.