Distinctions et publications

Promotion/nomination

Le Dr Michel Bouvier s’est vu attitré un second mandat de quatre ans au poste de directeur général de l’IRIC.

Prix et distinctions - chercheurs

En septembre dernier, le Dr Stephen Michnick a été accueilli à la Société royale du Canada en reconnaissance de l’excellence de ses réalisations scientifiques et universitaires. Ses travaux de recherche se concentrent sur l’étude de l’organisation des mécanismes cellulaires responsables de la prise de décision et de la mémoire. Leur objectif est d’améliorer la compréhension des interactions moléculaires sous-jacents les processus vivants.

Prix et distinctions - étudiants

Bourses post-doctorales externes

M. Musa Ozboyaci (laboratoire S. Pechmann) – IVADO
M. Pouria Dasmeh (laboratoire A. Serohijos) – IVADO
Mme Isabel De Oliveira Lima Bacellar (laboratoire S. Michnick)  –  HFSP (The International Human Frontier Science Program Organization)  –  Protein liquid-liquid phase separation as a mechanism of peroxisome matrix membrane transport

Bourse d’excellence Hydro-Québec

Cette bourse vise à souligner l’excellent parcours d’un étudiant menant des recherches dans des domaines liés aux champs d’action d’Hydro-Québec. Félicitation à Mme Christina Sawchyn, étudiante de 3e cycle du Département de biochimie et médecine moléculaire qui est la lauréate 2018. Mme Sawchyn est étudiante dans le laboratoire du Dr Frédérick-Antoine Mallette.
Bourse d’excellence J. A. DeSève
Nous félicitons Mme Bhagya Thimmappa pour l’obtention de la bourse d’excellence J. A, DeSève de la Faculté des études supérieures et postdoctorales. Mme Thimmappa est étudiante au doctorat dans le laboratoire du Dr Gertraud Burger.
Bourse de Mérite de la Faculté de Médecine
Mme Mélanie Breton-Larrivée, future étudiante à la maîtrise en biochimie (laboratoire S. McGraw)
M. Francis Leblanc, futur étudiant à la maîtrise en bio-informatique (laboratoire G. Lettre)
Bourse d’excellence 2018 de l’Association Médicale des Personnes de Race Noire du Québec
L’Université de Montréal ainsi que le Département de biochimie et médecine moléculaire souhaitent féliciter Mme Kayla Lewis-Thelusmon pour l’obtention de la bourse d’excellence 2018 de l’Association Médicale des Personnes de Race Noire du Québec (AMPRNQ). Cette dernière cherche à valoriser les étudiants de race noire en médecine ou en sciences de la santé qui s’investissent autant dans leurs études que dans leur communauté. Étudiante à la maîtrise en biochimie appliquée au milieu industriel et diplômée en enseignement postsecondaire, Kayla s’assure d’inclure autant que possible les notions de la communauté africaine et à descendance africaine dans tout ce qu’elle entreprend. Elle s’est donc démarquée par son implication à la plus ancienne entreprise de théâtre au Canada, soit le « Black Theatre Workshop », et au Festival International des Films Black de Montréal (FIFBM), mais également en faisant le parallèle entre culture et sciences. Elle aborde des sujets tels l’hydroquinone, un composant actif dans les produits éclaircissants topiques, l’albinisme et l’origine des premières cellules immortelles humaines HeLa, toujours exploitées aujourd’hui et dérobée d’une dame afro-américaine sans son consentement.

Publications 2019

Eisemann T, Langelier MF, Pascal JM. Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose dehydratase. J Biol Chem. 2019 Aug 2. pii: jbc.RA119.009200.

Pedersen MF, Wróbel TM, Märcher-Rørsted E, Pedersen DS, Møller TC, Gabriele F, Pedersen H, Matosiuk D, Foster SR, Bouvier M, Bräuner-Osborne H. Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics. Neuropharmacology. 2019 Jul 24:107718.

Akoume MY, Elbakry M, Veillette M, Franco A, Nada D, Labelle H, Mac-Thiong JM, Grimard G, Ouellet J, Parent S, Rivard CH, Lombardi G, Colombini A, Banfi G, Brayda-Bruno M, Gorman KF, Moreau A. A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep. 2019 Jul 11;9(1):10074.

Caron MC, Sharma AK, O’Sullivan J, Myler LR, Ferreira MT, Rodrigue A, Coulombe Y, Ethier C, Gagné JP, Langelier MF, Pascal JM, Finkelstein IJ, Hendzel MJ, Poirier GG, Masson JY. Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks. Nat Commun. 2019 Jul 4;10(1):2954.

Xiao R, Chen JY, Liang Z, Luo D, Chen G, Lu ZJ, Chen Y, Zhou B, Li H, Du X, Yang Y, San M, Wei X, Liu W, Lécuyer E, Graveley BR, Yeo GW, Burge CB, Zhang MQ, Zhou Y, Fu XD. Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription. Cell. 2019 Jun 27;178(1):107-121.e18.

Miller MM, Banville J, Friends T, Gagnon M, Hangeland JJ, Lavalee JF, Martel A, O’Grady H, Remillard R, Ruediger EH, Tremblay F, Posy S, Allegretto N, Guarino VR, Harden D, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson CA, Yang Y, Zhang G, Wong PC, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM, Priestley ES, Marinier A. Discovery of Potent Protease-Activated Receptor 4 Antagonists with in vivo Antithrombotic Efficacy. J Med Chem. 2019 Jun 27.

Fouillen A, Grenier D, Barbeau J, Baron C, Moffatt P, Nanci A. Selective bacterial degradation of the extracellular matrix attaching the gingiva to the tooth. Eur J Oral Sci. 2019 Jun 22. doi: 10.1111/eos.12623.

Reynders N, Abboud D, Baragli A, Noman MZ, Rogister B, Niclou SP, Heveker N, Janji B, Hanson J, Szpakowska M, Chevigné A. The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment. Cells. 2019 Jun 18;8(6). pii: E613.

Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, Lewcock JW, Yeo GW. Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Neuron. 2019 Jun 18. pii: S0896-6273(19)30524-0.

Wang W, Shen M, Fischer C, Basu R, Hazra S, Couvineau P, Paul M, Wang F, Toth S, Mix DS, Poglitsch M, Gerard NP, Bouvier M, Vederas JC, Penninger JM, Kassiri Z, Oudit GY. Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs. Proc Natl Acad Sci U S A. 2019 Jun 12.

Caland L, Labbé P, Mamarbachi M, Villeneuve L, Ferbeyre G, Noly PE, Carrier M, Thorin-Trescases N, Thorin É. Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice. Aging (Albany NY). 2019 Jun 11. doi: 10.18632/aging.102020.

Khoury S, Piltonen MH, Ton AT, Cole T, Samoshkin A, Smith SB, Belfer I, Slade GD, Fillingim RB, Greenspan JD, Ohrbach R, Maixner W, Neely GG, Serohijos AWR, Diatchenko L. A functional substitution in the L-aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway. Ann Neurol. 2019 Jun 8. doi: 10.1002/ana.25521.

Labiuk SL, Sygusch J, Grochulski P. Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan. Acta Crystallogr F Struct Biol Commun. 2019 Jun 1;75(Pt 6):405-411.

Rao S, Hassine S, Monette A, Amorim R, DesGroseillers L, Mouland AJ. HIV-1 requires Staufen1 to dissociate stress granules and to produce infectious viral particles. RNA. 2019 Jun;25(6):727-736.

Hurtubise R, Audiger C, Dominguez-Punaro MC, Chabot-Roy G, Chognard G, Raymond-Marchand L, Coderre L, Chemtob S, Michnick SW, Rioux JD, Lesage S. Induced and spontaneous colitis mouse models reveal complex interactions between IL-10 and IL-12/IL-23 pathways. Cytokine. 2019 May 31;121:154738.

Saint-Germain E, Mignacca L, Huot G, Acevedo M, Moineau-Vallée K, Calabrese V, Bourdeau V, Rowell MC, Ilangumaran S, Lessard F, Ferbeyre G. Phosphorylation of SOCS1 inhibits the SOCS1-p53 tumor suppressor axis. Cancer Res. 2019 May 17. pii: canres.1503.2018.

Velagapudi UK, Langelier MF, Delgado-Martin C, Diolaiti ME, Bakker S, Ashworth A, Patel BA, Shao X, Pascal JM, Talele TT. Design and Synthesis of Poly(ADP-ribose) polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. J Med Chem. 2019 May 1. doi: 10.1021/acs.jmedchem.8b01709.

Stanek M, Picard LP, Schmidt MF, Kaindl JM, Hübner H, Bouvier M, Weikert D, Gmeiner P. Hybridization of β-adrenergic agonists and antagonists confers G protein bias. J Med Chem. 2019 May 1. doi: 10.1021/acs.jmedchem.9b00349.

Bolognini D, Barki N, Butcher AJ, Hudson BD, Sergeev E, Molloy C, Moss CE, Bradley SJ, Le Gouill C, Bouvier M, Tobin AB, Milligan G. Chemogenetics defines receptor-mediated functions of short chain free fatty acids. Nat Chem Biol. 2019 May;15(5):489-498.

Bolognini D, Barki N, Butcher AJ, Hudson BD, Sergeev E, Molloy C, Moss CE, Bradley SJ, Le Gouill C, Bouvier M, Tobin AB, Milligan G. Chemogenetics defines receptor-mediated functions of short chain free fatty acids. Nat Chem Biol. 2019 May;15(5):489-498.

Mignaqui AC, Ruiz V, Durocher Y, Wigdorovitz A. Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids. Crit Rev Biotechnol. 2019 May;39(3):306-320.

Arya T, Oudouhou F, Casu B, Bessette B, Sygusch J, Baron C. Fragment-based screening identifies inhibitors of ATPase activity and of hexamer formation of Cagα from the Helicobacter pylori type IV secretion system. Sci Rep. 2019 Apr 24;9(1):6474.

Shayegan M, Tahvildari R, Metera K, Kisley L, Michnick SW, Leslie SR. Probing inhomogeneous diffusion in the microenvironments of phase-separated polymers under confinement. J Am Chem Soc. 2019 Apr 24. doi: 10.1021/jacs.8b13349.

Girard N, Dagenais P, Lacroix-Labonté J, Legault P. A multi-axial RNA joint with a large range of motion promotes sampling of an active ribozyme conformation. Nucleic Acids Res. 2019 Apr 23;47(7):3739-3751.

Poulain A, Mullick A, Massie B, Durocher Y. Reducing recombinant protein expression during CHO pool selection enhances frequency of high-producing cells. J Biotechnol. 2019 Apr 20;296:32-41.

Cohen-Armon M, Yeheskel A, Pascal JM. Signal-induced PARP1-Erk synergism mediates IEG expression. Signal Transduct Target Ther. 2019 Apr 12;4:8.

Kelil A, Michnick SW. Predicted amino acid motif repeats in proteins potentially encode extensive multivalent macromolecular assemblies in the human proteome. Curr Opin Struct Biol. 2019 Apr 9; 54:171-178.

Mellahi K, Brochu D, Gilbert M, Perrier M, Ansorge S, Durocher Y, Henry O. Assessment of Fed-batch Cultivation Strategies for an Inducible CHO Cell Line. J Biotechnol. 2019 Apr 5. pii: S0168-1656(19)30119-1.

Nada D, Julien C, Rompré PH, Akoume MY, Gorman KF, Samuels ME, Levy E, Kost J, Li D, Moreau A. Association of Circulating YKL-40 Levels and CHI3L1 Variants with the Risk of Spinal Deformity Progression in Adolescent Idiopathic Scoliosis. Sci Rep. 2019 Apr 5;9(1):5712.

Ghanbari F, Hebert-Losier A, Barry J, Poirier D, Giguere V, Mader S, Philip A. Isolation and functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy urine. J Steroid Biochem Mol Biol. 2019 Apr 4. pii: S0960-0760(18)30635-6.

Brejová B, Lichancová H, Brázdovič F, Hegedűsová E, Forgáčová Jakúbková M, Hodorová V, Džugasová V, Baláž A, Zeiselová L, Cillingová A, Neboháčová M, Raclavský V, Tomáška Ľ, Lang BF, Vinař T, Nosek J. Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus. Curr Genet. 2019 Apr;65(2):539-560.

Andrianjafy C, Luciano L, Bazin C, Baumstarck K, Bouvier M, Vitton V. Three-dimensional high-resolution anorectal manometry in functional anorectal disorders: results from a large observational cohort study. Int J Colorectal Dis. 2019 Apr;34(4):719-729.

Cambay F, Henry O, Durocher Y, De Crescenzo G. Impact of N-glycosylation on Fcγ receptor / IgG interactions: unravelling differences with an enhanced surface plasmon resonance biosensor assay based on coiled-coil interactions. MAbs. 2019 Apr;11(3):435-452.

Kobayashi H, Picard LP, Schönegge AM, Bouvier M. Bioluminescence resonance energy transfer-based imaging of protein-protein interactions in living cells. Nat Protoc. 2019 Mar 25. doi: 10.1038/s41596-019-0129-7.

Rao S, Hassine S, Monette A, Amorim R, DesGroseillers L, Mouland A. HIV-1 requires Staufen1 to dissociate stress granules and to produce infectious viral particles. RNA. 2019 Mar 22. pii: rna.069351.118

Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, Bourdeau V, Ferbeyre G, Lessard F. Ribosomal protein Rpl22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex. Cell Cycle. 2019 Mar 15. doi: 10.1080/15384101.2019.1593708.

Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL. Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons. iScience. 2019 Mar 15; 14:47-57.

Poulain A, Mullick A, Massie B, Durocher Y. Reducing recombinant protein expression during CHO pool selection enhances frequency of high-producing cells. J Biotechnol. 2019 Mar 15.

Gauthier L, Di Franco R, Serohijos AWR. SodaPop: A Forward Simulation Suite for the Evolutionary Dynamics of Asexual Populations on Protein Fitness Landscapes. Bioinformatics. 2019 Mar 13. pii: btz175. doi: 10.1093/bioinformatics/btz175.

Karam N, Lavoie JF, St-Jacques B, Bouhanik S, Franco A, Ladoul N, Moreau A. Bone-Specific Overexpression of PITX1 Induces Senile Osteoporosis in Mice Through Deficient Self-Renewal of Mesenchymal Progenitors and Wnt Pathway Inhibition. Sci Rep. 2019 Mar 5;9(1):3544.

Cambay F, Henry O, Durocher Y, De Crescenzo G. Impact of N-glycosylation on Fcγ receptor / IgG interactions: unravelling differences with an enhanced surface plasmon resonance biosensor assay based on coiled-coil interactions. MAbs. 2019 Mar 1. doi: 10.1080/19420862.2019.1581017.

Okeke K, Angers S, Bouvier M, Michel MC. Agonist-induced desensitisation of β3-adrenoceptors: where, when and how? Br J Pharmacol. 2019 Feb 27. doi: 10.1111/bph.14633.

Muñoz-Gómez SA, Hess S, Burger G, Lang BF, Susko E, Slamovits CH, Roger AJ. An updated phylogeny of the Alphaproteobacteria reveals that the Rickettsiales and Holosporales have independent origins. Elife. 2019 Feb 21;8. pii: e42535. doi: 10.7554/eLife.42535.

Lopes-Paciencia S, Saint-Germain E, Rowell MC, Ruiz AF, Kalegari P, Ferbeyre G. The senescence-associated secretory phenotype and its regulation. Cytokine. 2019 Feb 15; 117:15-22.

Lessard F, Brakier-Gingras L, Ferbeyre G. Ribosomal Proteins Control Tumor Suppressor Pathways in Response to Nucleolar Stress. Bioessays. 2019 Feb 1:e1800183. doi: 10.1002/bies.201800183.

Kasumba DM, Grandvaux N. Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome. Trends Pharmacol Sci. 2019 Feb;40 (2):116-127.

Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S. Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells. Oncogene. 2019 Feb;38(7):1019-1037.

Noutahi E, Calderon V, Blanchette M, El-Mabrouk N, Lang BF. Rapid genetic code evolution in green algal mitochondrial genomes. Mol Biol Evol. 2019 Jan 29. doi: 10.1093/molbev/msz016.

D’Eall C, Pon RA, Rossotti MA, Krahn N, Spearman M, Callaghan D, van Faassen H, Hussack G, Stetefeld J, Butler M, Durocher Y, Zhang J, Henry KA, Tanha J. Modulation of antibody-dependent cellular cytotoxicity of EGFR-specific heavy-chain antibodies through hinge engineering. Immunol Cell Biol. 2019 Jan 25. doi: 10.1111/imcb.12238.

Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 Jan 25;172(3):590-604.e13.

Mellahi K, Brochu D, Gilbert M, Perrier M, Ansorge S, Durocher Y, Henry O. Process intensification for the production of rituximab by an inducible CHO cell line. Bioprocess Biosyst Eng. 2019 Jan 23. doi: 10.1007/s00449-019-02075-z.

Mignaqui AC, Ruiz V, Durocher Y, Wigdorovitz A. Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids. Crit Rev Biotechnol. 2019 Jan 17:1-15.

Deschênes-Simard X, Parisotto M, Rowell MC, Le Calvé B, Igelmann S, Moineau-Vallée K, Saint-Germain E, Kalegari P, Bourdeau V, Kottakis F, Bardeesy N, Ferbeyre G. Circumventing senescence is associated with stem cell properties and metformin sensitivity. Aging Cell. 2019 Jan 6:e12889.

Weill U, Yofe I, Sass E, Stynen B, Davidi D, Natarajan J, Ben-Menachem R, Avihou Z, Goldman O, Harpaz N, Chuartzman S, Kniazev K, Knoblach B, Laborenz J, Boos F, Kowarzyk J, Ben-Dor S, Zalckvar E, Herrmann JM, Rachubinski RA, Pines O, RapaportD, Michnick SW, Levy ED, Schuldiner M. Genome-wide SWAp-Tag yeast libraries for proteome exploration. Nat Methods. 2019 Jan 2.

Lari A, Farzam F, Bensidoun P, Oeffinger M, Zenklusen D, Grunwald D, Montpetit B. Live-Cell Imaging of mRNP-NPC Interactions in Budding Yeast. Methods Mol Biol. 2019;2038:131-150. Lummertz da Rocha E, Malleshaiah M. Trajectory Algorithms to Infer Stem Cell Fate Decisions. Methods Mol Biol. 2019;1975:193-209.

Publications 2018

Bouvette J, Korkut DN, Fouillen A, Amellah S, Nanci A, Durocher Y, Omichinski JG, Legault P. High-yield production of human Dicer by transfection of human HEK293-EBNA1 cells grown in suspension. BMC Biotechnol. 2018 Dec 6;18(1):76.

Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA, Carlsson J, Kostenis E, Bouvier M, Schulte G, Hoffmann C. FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs. Sci Signal. 2018 Dec 4;11(559).

Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK. Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist. Nat Chem Biol. 2018 Nov 30;14(11):1059-1066.

Yao C, Wang C, Li Y, Zavortink M, Archambault V, Girton J, Johansen KM, Johansen J. Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation. PLoS One. 2018 Nov 28;13(11):e0208022.

Vaniotis G, Moffett S, Sulea T, Wang N, Elahi SM, Lessard E, Baardsnes J, Perrino S, Durocher Y, Frystyk J, Massie B, Brodt P. Enhanced anti-metastatic bioactivity of an IGF-TRAP re-engineered to improve physicochemical properties. Sci Rep. 2018 Nov 26;8(1):17361.

Langelier MF, Eisemann T, Riccio AA, Pascal JM. PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification. Curr Opin Struct Biol. 2018 Nov 24; 53:187-198.

Brejová B, Lichancová H, Brázdovič F, Hegedűsová E, Forgáčová Jakúbková M, Hodorová V, Džugasová V, Baláž A, Zeiselová L, Cillingová A, Neboháčová M, Raclavský V, Tomáška Ľ, Lang BF, Vinař T, Nosek J. Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus. Curr Genet. 2018 Nov 19. doi: 10.1007

Stynen B, Abd-Rabbo D, Kowarzyk J, Miller-Fleming L, Aulakh SK, Garneau P, Ralser M, Michnick SW. Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics. Cell. 2018 Nov 15;175(5):1418-1429.e9.

Heron P, Abellán-Flos M, Salmon L, Sygusch J. Bisphosphonate inhibitors of mammalian glycolytic aldolase. J Med Chem. 2018 Nov 12. doi: 10.1021.

Mellahi K, Cambay F, Brochu D, Gilbert M, Perrier M, Ansorge S, Durocher Y, Henry O. Process Development for an Inducible Rituximab-Expressing CHO Cell Line. Biotechnol Prog. 2018 Nov 10. doi: 10.1002.

Adivarahan S, Livingston N, Nicholson B, Rahman S, Wu B, Rissland OS, Zenklusen D. Spatial Organization of Single mRNPs at Different Stages of the Gene Expression Pathway. Mol Cell. 2018 Nov 2. pii: S1097-2765(18)30842-6.

Hamoud N, Tran V, Aimi T, Kakegawa W, Lahaie S, Thibault MP, Pelletier A, Wong GW, Kim IS, Kania A, Yuzaki M, Bouvier M, Côté JF. Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion. Nat Commun. 2018 Oct 26;9(1):4470.

Mende F, Hundahl C, Plouffe B, Skov LJ, Sivertsen B, Madsen AN, Lückmann M, Diep TA, Offermanns S, Frimurer TM, Bouvier M, Holst B. Translating biased signaling in the ghrelin receptor system into differential in vivo functions. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10255-E10264.

Hitchinson B, Eby JM, Gao X, Guite-Vinet F, Ziarek JJ, Abdelkarim H, Lee Y, Okamoto Y, Shikano S, Majetschak M, Heveker N, Volkman BF, Tarasova NI, Gaponenko V. Biased antagonism of CXCR4 avoids antagonist tolerance. Sci Signal. 2018 Oct 16;11(552).

Mehsen H, Boudreau V, Garrido D, Bourouh M, Larouche M, Maddox PS, Swan A, Archambault V. PP2A-B55 promotes nuclear envelope reformation after mitosis in Drosophila. J Cell Biol. 2018 Oct 11. doi: 10.1083/jcb.201804018.

Burger G, Valach M. Perfection of eccentricity: Mitochondrial genomes of diplonemids. IUBMB Life. 2018 Oct 10. doi: 10.1002/iub.1927.

Matralis AN, Xanthopoulos D, Huot G, Lopes-Paciencia S, Cole C, de Vries H, Ferbeyre G, Tsantrizos YS. Molecular tools that block maturation of the nuclear lamin A and decelerate cancer cell migration. Bioorg Med Chem. 2018 Oct 4. doi:10.1016/j.bmc.2018.10.001.

Perez-Romero CA, Lalonde M, Chartrand P, Cusanelli E. Induction and relocalization of telomeric repeat-containing RNAs during diauxic shift in budding yeast. Curr Genet. 2018 Oct;64(5):1117-1127.

Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJ. Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Sci Signal. 2018 Sep 25;11(549).

Yan Y, Acevedo M, Mignacca L, Desjardins P, Scott N, Imane R, Quenneville J, Robitaille J, Feghaly A, Gagnon E, Ferbeyre G, Major F. The sequence features that define efficient and specific hAGO2-dependent miRNA silencing guides. Nucleic Acids Res. 2018 Sep 19;46(16):8181-8196.

Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I. Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides. Cell Metab. 2018 Sep 17. pii: S1550-4131(18)30566-7.

Stuible M, Burlacu A, Perret S, Brochu D, Paul-Roc B, Baardsnes J, Loignon M, Grazzini E, Durocher Y. Optimization of a high-cell-density polyethylenimine transfection method for rapid protein production in CHO-EBNA1 cells. J Biotechnol. 2018 Sep 10;281:39-47.

Rodier F, Zhou D, Ferbeyre G. Cellular senescence, geroscience, cancer and beyond. Aging (Albany NY). 2018 Sep 7. doi: 10.18632/aging.101546.

Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S. Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells. Oncogene. 2018 Sep 6. doi: 10.1038/s41388-018-0468-9.

Pechmann S. Coping with stress by regulating tRNAs. Sci Signal. 2018 Sep 4;11(546).

Valach M, Léveillé-Kunst A, Gray MW, Burger G. Respiratory chain Complex I of unparalleled divergence in diplonemids. J Biol Chem. 2018 Aug 30. pii: jbc.RA118.005326.

Karamitri A, Plouffe B, Bonnefond A, Chen M, Gallion J, Guillaume JL, Hegron A, Boissel M, Canouil M, Langenberg C, Wareham NJ, Le Gouill C, Lukasheva V, Lichtarge O, Froguel P, Bouvier M, Jockers R. Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling. Sci Signal. 2018 Aug 28;11(545).

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