Distinctions et publications

Publications 2020

Kouwenhoven WM, Fortin G, Penttinen AM, Florence C, Delignat-Lavaud B, Bourque MJ, Trimbuch T, Luppi MP, Salvail-Lacoste A, Legault P, Poulin JF, Rosenmund C, Awatramani R, Trudeau LÉ. VGLUT2 EXPRESSION IN DOPAMINE NEURONS CONTRIBUTES TO POST-LESIONAL STRIATAL REINNERVATION. J Neurosci. 2020 Sep 14:JN-RM-0823-20.

Sundqvist M, Holdfeldt A, Wright SC, Møller TC, Siaw E, Jennbacken K, Franzyk H, Bouvier M, Dahlgren C, Forsman H. Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis. Biochim Biophys Acta Mol Cell Res. 2020 Sep 8:118849.

Lewandowski JP, Dumbović G, Watson AR, Hwang T, Jacobs-Palmer E, Chang N, Much C, Turner KM, Kirby C, Rubinstein ND, Groff AF, Liapis SC, Gerhardinger C, Bester A, Pandolfi PP, Clohessy JG, Hoekstra HE, Sauvageau M, Rinn JL. The Tug1 lncRNA locus is essential for male fertility. Genome Biol. 2020 Sep 7;21(1):237.

Shao Z, Lee BJ, Rouleau-Turcotte É, Langelier MF, Lin X, Estes VM, Pascal JM, Zha S. Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo. Nucleic Acids Res. 2020 Sep 5:gkaa718. doi: 10.1093/nar/gkaa718.

Valach M, Alcazar JAG, Sarrasin M, Lang BF, Gray MW, Burger G. An unexpectedly complex mitoribosome in Andalucia godoyi, a protist with the most bacteria-like mitochondrial genome. Mol Biol Evol. 2020 Sep 4:msaa223. doi: 10.1093/molbev/msaa223.

Abe KT, Li Z, Samson R, Samavarchi-Tehrani P, Valcourt EJ, Wood H, Budylowski P, Dupuis Ii AP, Girardin RC, Rathod B, Wang J, Barrios-Rodiles M, Colwill K, McGeer A, Mubareka S, Gommerman JL, Durocher Y, Ostrowski M, McDonough KA, Drebot MA, Drews SJ, Rini JM, Gingras AC. A simple protein-based surrogate neutralization assay for SARS-CoV-2. JCI Insight. 2020 Sep 1:142362.

Beauséjour M, Vaillancourt F, Akoume MY, Franco A, Parent S, Labelle H, Joncas J, Desbiens-Blais F, Mac-Thiong JM, Roy-Beaudry M, Aubin CÉ, Moreau A. Patient outcomes in idiopathic scoliosis are associated with biological endophenotypes: 2020 SOSORT award winner. Eur Spine J. 2020 Aug 29. doi: 10.1007/s00586-020-06579-1.

Okashah N, Wright SC, Kawakami K, Mathiasen S, Zhou J, Lu S, Javitch JA, Inoue A, Bouvier M, Lambert NA. Agonist-induced formation of unproductive receptor-G12 complexes. Proc Natl Acad Sci U S A. 2020 Aug 17:202003787. doi: 10.1073/pnas.2003787117.

Dagenais P, Legault P. In Vitro Selection of Varkud Satellite Ribozyme Variants that Cleave a Modified Stem-Loop Substrate. Methods Mol Biol. 2021;2167:61-77.

Ghanbari F, Mader S, Philip A. Cholesterol as an Endogenous Ligand of ERRα Promotes ERRα-Mediated Cellular Proliferation and Metabolic Target Gene Expression in Breast Cancer Cells. Cells. 2020 Jul 23;9(8):E1765.

Koirala S, Klein J, Zheng Y, Glenn NO, Eisemann T, Fon Tacer K, Miller DJ, Kulak O, Lu M, Finkelstein DB, Neale G, Tillman H, Vogel P, Strand DW, Lum L, Brautigam CA, Pascal JM, Clements WK, Potts PR. Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase. Cell Rep. 2020 Jul 21;32(3):107922.

Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D, Friguet B, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Gut P, Ivanchenko M, Legault V, Lemaître JF, Liontis T, Liu GH, Liu M, Maier AB, Nóbrega OT, Rikkert MGMO, Pawelec G, Rheault S, Senior AM, Simm A, Soo S, Traa A, Ukraintseva S, Vanhaelen Q, Van Raamsdonk JM, Witkowski JM, Yashin AI, Ziman R, Fülöp T. Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mech Ageing Dev. 2020 Jul 18:111316. doi: 10.1016/j.mad.2020.111316.

Bottardi S, Guieze R, Bourgoin V, Fotouhi-Ardakani N, Dougé A, Darracq A, Lakehal YA, Berger MG, Mollica L, Bay JO, Omichinski JG, Milot E. MNDA controls the expression of MCL-1 and BCL-2 in chronic lymphocytic leukemia cells. Exp Hematol. 2020 Jul 16. pii: S0301-472X(20)30269-1.

Kamada R, Kudoh F, Ito S, Tani I, Janairo JIB, Omichinski JG, Sakaguchi K. Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors. Pharmacol Ther. 2020 Jul 7:107622.

ENCODE Project Consortium, Moore JE, Purcaro MJ, Pratt HE, Epstein CB, Shoresh N, Adrian J, Kawli T, Davis CA, Dobin A, Kaul R, Halow J, Van Nostrand EL, Freese P, Gorkin DU, Shen Y, He Y, Mackiewicz M, Pauli-Behn F, Williams BA, Mortazavi A, Keller CA, Zhang XO, Elhajjajy SI, Huey J, Dickel DE, Snetkova V, Wei X, Wang X, Rivera-Mulia JC, Rozowsky J, Zhang J, Chhetri SB, Zhang J, Victorsen A, White KP, Visel A, Yeo GW, Burge CB, Lécuyer E, Gilbert DM, Dekker J, Rinn J, Mendenhall EM, Ecker JR, Kellis M, Klein RJ, Noble WS, Kundaje A, Guigó R, Farnham PJ, Cherry JM, Myers RM, Ren B, Graveley BR, Gerstein MB, Pennacchio LA, Snyder MP, Bernstein BE, Wold B, Hardison RC, Gingeras TR, Stamatoyannopoulos JA, Weng Z. Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature. 2020 Jul;583(7818):699-710.

Hassine S, Bonnet-Magnaval F, Benoit Bouvrette LP, Doran B, Ghram M, Bouthillette M, Lecuyer E, DesGroseillers L. Staufen1 localizes to the mitotic spindle and controls the localization of RNA populations to the spindle. J Cell Sci. 2020 Jun 23. pii: jcs.247155. doi: 10.1242/jcs.247155.

Faktorová D, Kaur B, Valach M, Graf L, Benz C, Burger G, Lukeš J. Targeted integration by homologous recombination enables in-situ tagging and replacement of genes in the marine microeukaryote Diplonema papillatum. Environ Microbiol. 2020 Jun 16. doi: 10.1111/1462-2920.15130.

Laprade H, Querido E, Smith MJ, Guérit D, Crimmins H, Conomos D, Pourret E, Chartrand P, Sfeir A. Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation. Mol Cell. 2020 May 29. pii: S1097-2765(20)30306-3.

Lukasheva V, Devost D, Le Gouill C, Namkung Y, Martin RD, Longpré JM, Amraei M, Shinjo Y, Hogue M, Lagacé M, Breton B, Aoki J, Tanny JC, Laporte SA, Pineyro G, Inoue A, Bouvier M, Hébert TE. Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR. Sci Rep. 2020 May 29;10(1):8779.

Srirangan K, Loignon M, Durocher Y. The use of site-specific recombination and cassette exchange technologies for monoclonal antibody production in Chinese Hamster ovary cells: retrospective analysis and future directions. Crit Rev Biotechnol. 2020 May 26:1-19. doi: 10.1080/07388551.

Baidya M, Kumari P, Dwivedi-Agnihotri H, Pandey S, Sokrat B, Sposini S, Chaturvedi M, Srivastava A, Roy D, Hanyaloglu AC, Bouvier M, Shukla AK. Genetically encoded intrabody sensors report the interaction and trafficking of β-arrestin 1 upon activation of G protein-coupled receptors. J Biol Chem. 2020 May 21. pii: jbc.RA120.013470.

Nourreddine S, Lavoie G, Paradis J, Ben El Kadhi K, Méant A, Aubert L, Grondin B, Gendron P, Chabot B, Bouvier M, Carreno S, Roux PP.     NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay. Cell Rep. 2020 May 19;31(7):107660.

Chartrand P, Jaramillo M, Gamberi C. Editorial: RNA Regulation in Development and Disease. Front Genet. 2020 Apr 28;11:430. doi: 10.3389/fgene.2020.00430.

Ghram M, Bonnet-Magnaval F, Hotea DI, Doran B, Ly S, DesGroseillers L. Staufen1 is essential for cell cycle transitions and cell proliferation via the control of E2F1 expression. J Mol Biol. 2020 Apr 23. pii: S0022-2836(20)30304-1.

Lussier-Price M, Mascle XH, Cappadocia L, Kamada R, Sakaguchi K, Wahba HM, Omichinski JG. Characterization of a C-Terminal SUMO-Interacting Motif Present in Select PIAS-Family Proteins. Structure. 2020 Apr 22. pii: S0969-2126(20)30121-0.

Rahim MMA,  Parsons BD,  Price EL,  Slaine PD,  Chilvers BL,  Seaton GS,  Wight A,  Medina-Luna D,  Dey S,  Grandy SL,  Anderson LE,  Zamorano Cuervo N,  Grandvaux N,  Gaglia MM,  Kelvin AA,  Khaperskyy DA,  McCormick C,  Makrigiannis AP. Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins. J Virol. 2020 Jun 16;94(13):e00165-20. Faktorová D, Nisbet RER, Fernández Robledo JA, Casacuberta E, Sudek L, Allen AE, Ares M Jr, Aresté C, Balestreri C, Barbrook AC, Beardslee P, Bender S, Booth DS, Bouget FY, Bowler C, Breglia SA, Brownlee C, Burger G, Cerutti H,Cesaroni R, Chiurillo MA, Clemente T, Coles DB, Collier JL, Cooney EC, Coyne K, Docampo R, Dupont CL, Edgcomb V, Einarsson E, Elustondo PA, Federici F, Freire-Beneitez V, Freyria NJ, Fukuda K, García PA, Girguis PR, Gomaa F, Gornik SG, Guo J, Hampl V, HanawaY, Haro-Contreras ER, Hehenberger E, Highfield A, Hirakawa Y, Hopes A, Howe CJ, Hu I, Ibañez J, Irwin NAT, Ishii Y, Janowicz NE, Jones AC, Kachale A, Fujimura-Kamada K, Kaur B, Kaye JZ, Kazana E, Keeling PJ, King N, Klobutcher LA, Lander N, Lassadi I, Li Z,Lin S, Lozano JC, Luan F, Maruyama S, Matute T, Miceli C, Minagawa J, Moosburner M, Najle SR, Nanjappa D, Nimmo IC, Noble L, Novák Vanclová AMG, Nowacki M, Nuñez I, Pain A, Piersanti A, Pucciarelli S, Pyrih J, Rest JS, Rius M, Robertson D, Ruaud A, Ruiz-TrilloI, Sigg MA, Silver PA, Slamovits CH, Jason Smith G, Sprecher BN, Stern R, Swart EC, Tsaousis AD, Tsypin L, Turkewitz A, Turnšek J, Valach M, Vergé V, von Dassow P, von der Haar T, Waller RF, Wang L, Wen X, Wheeler G, Woods A, Zhang H, Mock T, Worden AZ, Lukeš J. Genetic tool development in marine protists: emerging model organisms for experimental cell biology. Nat Methods. 2020 Apr 6. doi: 10.1038/s41592-020-0796-x.

Zandarashvili L, Langelier MF, Velagapudi UK, Hancock MA, Steffen JD, Billur R, Hannan ZM, Wicks AJ, Krastev DB, Pettitt SJ, Lord CJ, Talele TT, Pascal JM, Black BE. Structural basis for allosteric PARP-1 retention on DNA breaks. Science. 2020 Apr 3;368(6486).

Cambay F, Forest-Nault C, Dumoulin L, Seguin A, Henry O, Durocher Y, De Crescenzo G. Glycosylation of Fcγ receptors influences their interaction with various IgG1 glycoforms. Mol Immunol. 2020 Mar 26;121:144-158.

Camacho D, Frazao R, Fouillen A, Nanci A, Lang BF, Apte SC, Baron C, Warren LA. New Insights Into Acidithiobacillus thiooxidans Sulfur Metabolism Through Coupled Gene Expression, Solution Chemistry, Microscopy, and Spectroscopy Analyses. Front Microbiol. 2020 Mar 13;11:411.

Bergalet J, Patel D, Legendre F, Lapointe C, Benoit Bouvrette LP, Chin A, Blanchette M, Kwon E, Lécuyer E. Inter-dependent Centrosomal Co-localization of the cen and ik2 cis-Natural Antisense mRNAs in Drosophila. Cell Rep. 2020 Mar 10;30(10):3339-3352.

Gray MW, Burger G, Derelle R, Klimeš V, Leger MM, Sarrasin M, Vlček Č, Roger AJ, Eliáš M, Lang BF. The draft nuclear genome sequence and predicted mitochondrial proteome of Andalucia godoyi, a protist with the most gene-rich and bacteria-like mitochondrial genome. BMC Biol. 2020 Mar 2;18(1):22. doi: 10.1186/s12915-020-0741-6.

Manenda MS, Picard MÈ, Zhang L, Cyr N, Zhu X, Barma J, Pascal JM, Couture M, Zhang C, Shi R. Structural analyses of the group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations. J Biol Chem. 2020 Feb 28. pii: jbc.RA119.011212.

Jasinska W, Manhart M, Lerner J, Gauthier L, Serohijos AWR, Bershtein S. Chromosomal barcoding of E. coli populations reveals lineage diversity dynamics at high resolution. Nat Ecol Evol. 2020 Feb 24. doi: 10.1038/s41559-020-1103-z.

Lalonde M, Chartrand P. TERRA, a multifaceted regulator of telomerase activity at telomeres. J Mol Biol. 2020 Feb 18. pii: S0022-2836(20)30154-6.

Alexander RA, Lot I, Saha K, Abadie G, Lambert M, Decosta E, Kobayashi H, Beautrait A, Borrull A, Asnacios A, Bouvier M, Scott MGH, Marullo S, Enslen H. Beta-arrestins operate an on/off control switch for focal adhesion kinase activity. Cell Mol Life Sci. 2020 Feb 10. doi: 10.1007/s00018-020-03471-5.

Semmler S, Gagné M, Garg P, Pickles SR , Baudouin C, Hamon-Keromen E, Destroismaisons L, Khalfallah Y, Chaineau M, Caron E , Bayne AN, Trempe JF, Cashman NR, Star AT, Haqqani AS, Durcan TM, Meiering EM, Robertson J, Grandvaux N, Plotkin SS, McBride HM, Vande Velde C. TNF receptor associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation. J Biol Chem. 2020 Feb 6. pii: jbc.RA119.011215.

Nakagawa N, Sakaguchi S, Nomura T, Kamada R, Omichinski JG, Sakaguchi K. The tetramerization domain of the tree shrew p53 protein displays unique thermostability despite sharing high sequence identity with the human p53 protein. Biochem Biophys Res Commun. 2020 Jan 15;521(3):681-686.

Kaur B, Záhonová K, Valach M, Faktorová D, Prokopchuk G, Burger G, Lukeš J. Gene fragmentation and RNA editing without borders: eccentric mitochondrial genomes of diplonemids. Nucleic Acids Res. 2020 Jan 10. pii: gkz1215. doi: 10.1093/nar/gkz1215.

Lalonde ME, Koyuturk I, Brochu D, Jabbour J, Gilbert M, Durocher Y. Production of α2,6-sialylated and non-fucosylated recombinant alpha-1-antitrypsin in CHO cells. J Biotechnol. 2020 Jan 10;307:87-97.

Benoit Bouvrette LP, Bovaird S, Blanchette M, Lécuyer E. oRNAment: a database of putative RNA binding protein target sites in the transcriptomes of model species. Nucleic Acids Res. 2020 Jan 8;48(D1):D166-D173.

Eisemann T, Pascal JM. Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity. Cell Mol Life Sci. 2020 Jan;77(1):19-33.

Zhang J, Cheuk KY, Xu L, Wang Y, Feng Z, Sit T, Cheng KLNepotchatykh E, Lam TP, Liu Z, Hung ALH, Zhu Z, Moreau A, Cheng JCY, Qiu Y, Lee WYW. A validated composite model to predict risk of curve progression in adolescent idiopathic scoliosis. EClinicalMedicine. 2020 Jan 5;18:100236.

Publications 2019

Joubert S, Dodelet V, Béliard R, Durocher Y. Biomanufacturing of monoclonal antibodies. Med Sci (Paris). 2019 Dec;35(12):1153-1159.

Hasan ABMSU, Kurata H, Pechmann S. Improvement of the memory function of a mutual repression network in a stochastic environment by negative autoregulation. BMC Bioinformatics. 2019 Dec 27;20(1):734.

Lessard F, Saint-Germain E, Mignacca L, Ferbeyre G. SOCS1: phosphorylation, dimerization and tumor suppression. Oncoscience. 2019 Dec 23;6(11-12):386-389.

Mascle XH, Gagnon C, Wahba HM, Lussier-Price M, Cappadocia L, Sakaguchi K, Omichinski JG. Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. Structure. 2019 Dec 23. pii: S0969-2126(19)30437-X.

Gauthier L, Stynen B, Serohijos AWR, Michnick SW. Genetics’ Piece of the PI: Inferring the Origin of Complex Traits and Diseases from Proteome-Wide Protein-Protein Interaction Dynamics. Bioessays. 2019 Dec 18:e1900169.

Deschênes-Simard X, Rowell MC, Ferbeyre G. Metformin turns off the metabolic switch of pancreatic cancer. Aging (Albany NY). 2019 Dec 12. doi: 10.18632/aging.102622.

Scott DD, Aguilar LC, Kramar M, Oeffinger M. It’s Not the Destination, It’s the Journey: Heterogeneity in mRNA Export Mechanisms. Adv Exp Med Biol. 2019;1203:33-81.

Sauvageau M. Diverging RNPs: Toward Understanding lncRNA-Protein Interactions and Functions. Adv Exp Med Biol. 2019;1203:285-312.

Adivarahan S, Zenklusen D. Lessons from (pre-)mRNA Imaging. Adv Exp Med Biol. 2019;1203:247-284.

Benoit Bouvrette LP, Blanchette M, Lécuyer E. Bioinformatics Approaches to Gain Insights into cis-Regulatory Motifs Involved in mRNA Localization. Adv Exp Med Biol. 2019;1203:165-194.

Eisemann T, Pascal JM. Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity. Cell Mol Life Sci. 2019 Nov 21. doi: 10.1007/s00018-019-03366-0.

Benoit Bouvrette LP, Bovaird S, Blanchette M, Lécuyer E. oRNAment: a database of putative RNA binding protein target sites in the transcriptomes of model species. Nucleic Acids Res. 2019 Nov 14. pii: gkz986.

García RA, Ito BR, Lupisella JA, Carson NA, Hsu MY, Fernando G, Heroux M, Bouvier M, Dierks E, Kick EK, Gordon DA, Chen J, Mintier G, Carrier M, St-Onge S, Shah H, Towne J, Bucardo MS, Ma X, Ryan CS, Wurtz NR, Ostrowski J, Villarreal FJ. Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment. JACC Basic Transl Sci. 2019 Nov 13;4(8):905-920.

Chen G, Gerrior A, Durocher Y, Ghosh R. Efficient capture of monoclonal antibody from cell culture supernatant using protein A media contained in a cuboid packed-bed device. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Nov 12;1134-1135:121853.

Coutinho de Oliveira L, Volpon L, Rahardjo AK, Osborne MJ, Culjkovic-Kraljacic B, Trahan C, Oeffinger M, Kwok BH, Borden KLB. Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation. Proc Natl Acad Sci U S A. 2019 Nov 11. pii: 201904752.

Bury M, Le Calvé B, Lessard F, Dal Maso T, Saliba J, Michiels C, Ferbeyre G, Blank V. NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor. Cell Rep. 2019 Nov 5;29(6):1469-1481.e9.

Lalonde ME, Koyuturk I, Brochu D, Jabbour J, Gilbert M, Durocher Y. Production of α2,6-sialylated and non-fucosylated recombinant alpha-1-antitrypsin in CHO cells. J Biotechnol. 2019 Nov 4. pii: S0168-1656(19)30909-5.

Nakagawa N, Sakaguchi S, Nomura T, Kamada R, Omichinski JG, Sakaguchi K. The tetramerization domain of the tree shrew p53 protein displays unique thermostability despite sharing high sequence identity with the human p53 protein. Biochem Biophys Res Commun. 2019 Nov 2. pii: S0006-291X(19)32032-7.

Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, Von Zglinicki T, Zhou D, Serrano M, Demaria M. Cellular Senescence: Defining a Path Forward. Cell. 2019 Oct 31;179(4):813-827.

Gizak A, Wiśniewski J, Heron P, Mamczur P, Sygusch J, Rakus D. Targeting a moonlighting function of aldolase induces apoptosis in cancer cells. Cell Death Dis. 2019 Sep 26;10(10):712.

Igelmann S, Neubauer HA, Ferbeyre G. STAT3 and STAT5 Activation in Solid Cancers. Cancers (Basel). 2019 Sep 25; 11(10).

Kong J, Han H, Bergalet J, Bouvrette LPB, Hernández G, Moon NS, Vali H, Lécuyer É, Lasko P. A ribosomal protein S5 isoform is essential for oogenesis and interacts with distinct RNAs in Drosophila melanogaster. Sci Rep. 2019 Sep 24; 9(1):13779.

Draceni Y, Pechmann S. Pervasive convergent evolution and extreme phenotypes define chaperone requirements of protein homeostasis. Proc Natl Acad Sci U S A. 2019 Sep 16. pii: 201904611.

Benredjem B, Gallion J, Pelletier D, Dallaire P, Charbonneau J, Cawkill D, Nagi K, Gosink M, Lukasheva V, Jenkinson S, Ren Y, Somps C, Murat B, Van Der Westhuizen E, Le Gouill C, Lichtarge O, Schmidt A, Bouvier M, Pineyro G. Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response. Nat Commun. 2019 Sep 9;10(1):4075. doi: 10.1038/s41467-019-11875-6.

Mariani MK, Dasmeh P, Fortin A, Caron E, Kalamujic M, Harrison AN,4, Hotea D, Kasumba DM, Cervantes-Ortiz SL, Mukawera E, Serohijos AWR, Grandvaux N. The Combination of IFN β and TNF Induces an Antiviral and Immunoregulatory Program via Non-Canonical Pathways Involving STAT2 and IRF9. Cells. 2019 Aug 17;8(8). pii: E919.

Zhou TE, Zhu T, Rivera JC, Omri S, Tahiri H, Lahaie I, Rouget R, Wirth M, Nattel S, Lodygensky G, Ferbeyre G, Nezhady M, Desjarlais M, Hamel P, Chemtob S. The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased P53/mir-Let-7b Activity. Am J Pathol. 2019 Aug 17. pii: S0002-9440(19)30665-0.

Eisemann T, Langelier MF, Pascal JM. Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose dehydratase. J Biol Chem. 2019 Aug 2. pii: jbc.RA119.009200.

Pedersen MF, Wróbel TM, Märcher-Rørsted E, Pedersen DS, Møller TC, Gabriele F, Pedersen H, Matosiuk D, Foster SR, Bouvier M, Bräuner-Osborne H. Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics. Neuropharmacology. 2019 Jul 24:107718.

Yan Z, Lécuyer E, Blanchette M. Prediction of mRNA subcellular localization using deep recurrent neural networks. Bioinformatics. 2019 Jul 15;35(14):i333-i342.

Akoume MY, Elbakry M, Veillette M, Franco A, Nada D, Labelle H, Mac-Thiong JM, Grimard G, Ouellet J, Parent S, Rivard CH, Lombardi G, Colombini A, Banfi G, Brayda-Bruno M, Gorman KF, Moreau A. A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep. 2019 Jul 11;9(1):10074.

Caron MC, Sharma AK, O’Sullivan J, Myler LR, Ferreira MT, Rodrigue A, Coulombe Y, Ethier C, Gagné JP, Langelier MF, Pascal JM, Finkelstein IJ, Hendzel MJ, Poirier GG, Masson JY. Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks. Nat Commun. 2019 Jul 4;10(1):2954.

Xiao R, Chen JY, Liang Z, Luo D, Chen G, Lu ZJ, Chen Y, Zhou B, Li H, Du X, Yang Y, San M, Wei X, Liu W, Lécuyer E, Graveley BR, Yeo GW, Burge CB, Zhang MQ, Zhou Y, Fu XD. Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription. Cell. 2019 Jun 27;178(1):107-121.e18.

Miller MM, Banville J, Friends T, Gagnon M, Hangeland JJ, Lavalee JF, Martel A, O’Grady H, Remillard R, Ruediger EH, Tremblay F, Posy S, Allegretto N, Guarino VR, Harden D, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson CA, Yang Y, Zhang G, Wong PC, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM, Priestley ES, Marinier A. Discovery of Potent Protease-Activated Receptor 4 Antagonists with in vivo Antithrombotic Efficacy. J Med Chem. 2019 Jun 27.

Fouillen A, Grenier D, Barbeau J, Baron C, Moffatt P, Nanci A. Selective bacterial degradation of the extracellular matrix attaching the gingiva to the tooth. Eur J Oral Sci. 2019 Jun 22. doi: 10.1111/eos.12623.

Reynders N, Abboud D, Baragli A, Noman MZ, Rogister B, Niclou SP, Heveker N, Janji B, Hanson J, Szpakowska M, Chevigné A. The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment. Cells. 2019 Jun 18;8(6). pii: E613.

Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, Lewcock JW, Yeo GW. Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Neuron. 2019 Jun 18. pii: S0896-6273(19)30524-0.

Wang W, Shen M, Fischer C, Basu R, Hazra S, Couvineau P, Paul M, Wang F, Toth S, Mix DS, Poglitsch M, Gerard NP, Bouvier M, Vederas JC, Penninger JM, Kassiri Z, Oudit GY. Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs. Proc Natl Acad Sci U S A. 2019 Jun 12.

Caland L, Labbé P, Mamarbachi M, Villeneuve L, Ferbeyre G, Noly PE, Carrier M, Thorin-Trescases N, Thorin É. Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice. Aging (Albany NY). 2019 Jun 11. doi: 10.18632/aging.102020.

Mellahi K, Brochu D, Gilbert M, Perrier M, Ansorge S, Durocher Y, Henry O. Assessment of Fed-batch Cultivation Strategies for an Inducible CHO Cell Line. J Biotechnol. 2019 Jun 10;298:45-56.

Khoury S, Piltonen MH, Ton AT, Cole T, Samoshkin A, Smith SB, Belfer I, Slade GD, Fillingim RB, Greenspan JD, Ohrbach R, Maixner W, Neely GG, Serohijos AWR, Diatchenko L. A functional substitution in the L-aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway. Ann Neurol. 2019 Jun 8. doi: 10.1002/ana.25521.

Labiuk SL, Sygusch J, Grochulski P. Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan. Acta Crystallogr F Struct Biol Commun. 2019 Jun 1;75(Pt 6):405-411.

Rao S, Hassine S, Monette A, Amorim R, DesGroseillers L, Mouland AJ. HIV-1 requires Staufen1 to dissociate stress granules and to produce infectious viral particles. RNA. 2019 Jun;25(6):727-736.

Mary C, Baron C. Bases moléculaires de l’infection de plantes par Agrobacterium tumefaciens via un système de sécrétion de type IV 1. Biochem Cell Biol. 2019 Jun;97(3):215-223.

Hurtubise R, Audiger C, Dominguez-Punaro MC, Chabot-Roy G, Chognard G, Raymond-Marchand L, Coderre L, Chemtob S, Michnick SW, Rioux JD, Lesage S. Induced and spontaneous colitis mouse models reveal complex interactions between IL-10 and IL-12/IL-23 pathways. Cytokine. 2019 May 31;121:154738.

Saint-Germain E, Mignacca L, Huot G, Acevedo M, Moineau-Vallée K, Calabrese V, Bourdeau V, Rowell MC, Ilangumaran S, Lessard F, Ferbeyre G. Phosphorylation of SOCS1 inhibits the SOCS1-p53 tumor suppressor axis. Cancer Res. 2019 May 17. pii: canres.1503.2018.

Velagapudi UK, Langelier MF, Delgado-Martin C, Diolaiti ME, Bakker S, Ashworth A, Patel BA, Shao X, Pascal JM, Talele TT. Design and Synthesis of Poly(ADP-ribose) polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. J Med Chem. 2019 May 1. doi: 10.1021/acs.jmedchem.8b01709.

Stanek M, Picard LP, Schmidt MF, Kaindl JM, Hübner H, Bouvier M, Weikert D, Gmeiner P. Hybridization of β-adrenergic agonists and antagonists confers G protein bias. J Med Chem. 2019 May 1. doi: 10.1021/acs.jmedchem.9b00349.

Bolognini D, Barki N, Butcher AJ, Hudson BD, Sergeev E, Molloy C, Moss CE, Bradley SJ, Le Gouill C, Bouvier M, Tobin AB, Milligan G. Chemogenetics defines receptor-mediated functions of short chain free fatty acids. Nat Chem Biol. 2019 May;15(5):489-498.

Bolognini D, Barki N, Butcher AJ, Hudson BD, Sergeev E, Molloy C, Moss CE, Bradley SJ, Le Gouill C, Bouvier M, Tobin AB, Milligan G. Chemogenetics defines receptor-mediated functions of short chain free fatty acids. Nat Chem Biol. 2019 May;15(5):489-498.

Mignaqui AC, Ruiz V, Durocher Y, Wigdorovitz A. Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids. Crit Rev Biotechnol. 2019 May;39(3):306-320.

Mellahi K, Brochu D, Gilbert M, Perrier M, Ansorge S, Durocher Y, Henry O. Process intensification for the production of rituximab by an inducible CHO cell line. Bioprocess Biosyst Eng. 2019 May;42(5):711-725.

Arya T, Oudouhou F, Casu B, Bessette B, Sygusch J, Baron C. Fragment-based screening identifies inhibitors of ATPase activity and of hexamer formation of Cagα from the Helicobacter pylori type IV secretion system. Sci Rep. 2019 Apr 24;9(1):6474.

Shayegan M, Tahvildari R, Metera K, Kisley L, Michnick SW, Leslie SR. Probing inhomogeneous diffusion in the microenvironments of phase-separated polymers under confinement. J Am Chem Soc. 2019 Apr 24. doi: 10.1021/jacs.8b13349.

Girard N, Dagenais P, Lacroix-Labonté J, Legault P. A multi-axial RNA joint with a large range of motion promotes sampling of an active ribozyme conformation. Nucleic Acids Res. 2019 Apr 23;47(7):3739-3751.

Poulain A, Mullick A, Massie B, Durocher Y. Reducing recombinant protein expression during CHO pool selection enhances frequency of high-producing cells. J Biotechnol. 2019 Apr 20;296:32-41.

Cohen-Armon M, Yeheskel A, Pascal JM. Signal-induced PARP1-Erk synergism mediates IEG expression. Signal Transduct Target Ther. 2019 Apr 12;4:8.

Kelil A, Michnick SW. Predicted amino acid motif repeats in proteins potentially encode extensive multivalent macromolecular assemblies in the human proteome. Curr Opin Struct Biol. 2019 Apr 9; 54:171-178.

Nada D, Julien C, Rompré PH, Akoume MY, Gorman KF, Samuels ME, Levy E, Kost J, Li D, Moreau A. Association of Circulating YKL-40 Levels and CHI3L1 Variants with the Risk of Spinal Deformity Progression in Adolescent Idiopathic Scoliosis. Sci Rep. 2019 Apr 5;9(1):5712.

Ghanbari F, Hebert-Losier A, Barry J, Poirier D, Giguere V, Mader S, Philip A. Isolation and functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy urine. J Steroid Biochem Mol Biol. 2019 Apr 4. pii: S0960-0760(18)30635-6.

Brejová B, Lichancová H, Brázdovič F, Hegedűsová E, Forgáčová Jakúbková M, Hodorová V, Džugasová V, Baláž A, Zeiselová L, Cillingová A, Neboháčová M, Raclavský V, Tomáška Ľ, Lang BF, Vinař T, Nosek J. Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus. Curr Genet. 2019 Apr;65(2):539-560.

Andrianjafy C, Luciano L, Bazin C, Baumstarck K, Bouvier M, Vitton V. Three-dimensional high-resolution anorectal manometry in functional anorectal disorders: results from a large observational cohort study. Int J Colorectal Dis. 2019 Apr;34(4):719-729.

Cambay F, Henry O, Durocher Y, De Crescenzo G. Impact of N-glycosylation on Fcγ receptor / IgG interactions: unravelling differences with an enhanced surface plasmon resonance biosensor assay based on coiled-coil interactions. MAbs. 2019 Apr;11(3):435-452.

Kobayashi H, Picard LP, Schönegge AM, Bouvier M. Bioluminescence resonance energy transfer-based imaging of protein-protein interactions in living cells. Nat Protoc. 2019 Mar 25. doi: 10.1038/s41596-019-0129-7.

Rao S, Hassine S, Monette A, Amorim R, DesGroseillers L, Mouland A. HIV-1 requires Staufen1 to dissociate stress granules and to produce infectious viral particles. RNA. 2019 Mar 22. pii: rna.069351.118

Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, Bourdeau V, Ferbeyre G, Lessard F. Ribosomal protein Rpl22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex. Cell Cycle. 2019 Mar 15. doi: 10.1080/15384101.2019.1593708.

Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL. Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons. iScience. 2019 Mar 15; 14:47-57.

Poulain A, Mullick A, Massie B, Durocher Y. Reducing recombinant protein expression during CHO pool selection enhances frequency of high-producing cells. J Biotechnol. 2019 Mar 15.

Gauthier L, Di Franco R, Serohijos AWR. SodaPop: A Forward Simulation Suite for the Evolutionary Dynamics of Asexual Populations on Protein Fitness Landscapes. Bioinformatics. 2019 Mar 13. pii: btz175. doi: 10.1093/bioinformatics/btz175.

Karam N, Lavoie JF, St-Jacques B, Bouhanik S, Franco A, Ladoul N, Moreau A. Bone-Specific Overexpression of PITX1 Induces Senile Osteoporosis in Mice Through Deficient Self-Renewal of Mesenchymal Progenitors and Wnt Pathway Inhibition. Sci Rep. 2019 Mar 5;9(1):3544.

Cambay F, Henry O, Durocher Y, De Crescenzo G. Impact of N-glycosylation on Fcγ receptor / IgG interactions: unravelling differences with an enhanced surface plasmon resonance biosensor assay based on coiled-coil interactions. MAbs. 2019 Mar 1. doi: 10.1080/19420862.2019.1581017.

Okeke K, Angers S, Bouvier M, Michel MC. Agonist-induced desensitisation of β3-adrenoceptors: where, when and how? Br J Pharmacol. 2019 Feb 27. doi: 10.1111/bph.14633.

Muñoz-Gómez SA, Hess S, Burger G, Lang BF, Susko E, Slamovits CH, Roger AJ. An updated phylogeny of the Alphaproteobacteria reveals that the Rickettsiales and Holosporales have independent origins. Elife. 2019 Feb 21;8. pii: e42535. doi: 10.7554/eLife.42535.

Lopes-Paciencia S, Saint-Germain E, Rowell MC, Ruiz AF, Kalegari P, Ferbeyre G. The senescence-associated secretory phenotype and its regulation. Cytokine. 2019 Feb 15; 117:15-22.

Lessard F, Brakier-Gingras L, Ferbeyre G. Ribosomal Proteins Control Tumor Suppressor Pathways in Response to Nucleolar Stress. Bioessays. 2019 Feb 1:e1800183. doi: 10.1002/bies.201800183.

Kasumba DM, Grandvaux N. Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome. Trends Pharmacol Sci. 2019 Feb;40 (2):116-127.

Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S. Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells. Oncogene. 2019 Feb;38(7):1019-1037.

Noutahi E, Calderon V, Blanchette M, El-Mabrouk N, Lang BF. Rapid genetic code evolution in green algal mitochondrial genomes. Mol Biol Evol. 2019 Jan 29. doi: 10.1093/molbev/msz016.

D’Eall C, Pon RA, Rossotti MA, Krahn N, Spearman M, Callaghan D, van Faassen H, Hussack G, Stetefeld J, Butler M, Durocher Y, Zhang J, Henry KA, Tanha J. Modulation of antibody-dependent cellular cytotoxicity of EGFR-specific heavy-chain antibodies through hinge engineering. Immunol Cell Biol. 2019 Jan 25. doi: 10.1111/imcb.12238.

Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 Jan 25;172(3):590-604.e13.

Mignaqui AC, Ruiz V, Durocher Y, Wigdorovitz A. Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids. Crit Rev Biotechnol. 2019 Jan 17:1-15.

Deschênes-Simard X, Parisotto M, Rowell MC, Le Calvé B, Igelmann S, Moineau-Vallée K, Saint-Germain E, Kalegari P, Bourdeau V, Kottakis F, Bardeesy N, Ferbeyre G. Circumventing senescence is associated with stem cell properties and metformin sensitivity. Aging Cell. 2019 Jan 6:e12889.

Weill U, Yofe I, Sass E, Stynen B, Davidi D, Natarajan J, Ben-Menachem R, Avihou Z, Goldman O, Harpaz N, Chuartzman S, Kniazev K, Knoblach B, Laborenz J, Boos F, Kowarzyk J, Ben-Dor S, Zalckvar E, Herrmann JM, Rachubinski RA, Pines O, RapaportD, Michnick SW, Levy ED, Schuldiner M. Genome-wide SWAp-Tag yeast libraries for proteome exploration. Nat Methods. 2019 Jan 2.

Mellahi K, Cambay F, Brochu D, Gilbert M, Perrier M, Ansorge S, Durocher Y, Henry O. Process development for an inducible rituximab-expressing Chinese hamster ovarycell line. Biotechnol Prog. 2019 Jan;35(1):e2742.

Lari A, Farzam F, Bensidoun P, Oeffinger M, Zenklusen D, Grunwald D, Montpetit B. Live-Cell Imaging of mRNP-NPC Interactions in Budding Yeast. Methods Mol Biol. 2019;2038:131-150.

Lummertz da Rocha E, Malleshaiah M. Trajectory Algorithms to Infer Stem Cell Fate Decisions. Methods Mol Biol. 2019;1975:193-209.