Professor
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Contact informationDépartement de biochimie |
.P 514 343-7571 |
Themes
My laboratory is interested in uncovering the molecular mechanism of tumor suppression. These mechanisms involve sensors that detect oncogenic stress and effector pathways that prevent the proliferative expansion of potentially malignant cells. Our work on senescence is leading us towards new mechanism of triggering anti-tumor immune response. We thus view cell senescence, not only as a way to stop the proliferation of incipient tumors but also as a mechanism to alert the immune system of a tumor threat and developing lasting antitumor immunity. Using proteomics, RNA interference and CRISPR screening we have identified many genes with unsuspected roles in tumor suppression and cellular senescence. Many of the genes can potentially regulate the immune system. |
Publications
- Moiseeva O, Lessard F, Acevedo-Aquino M, Vernier M, Tsantrizos YS, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015 Aug 3;14(15):2408-2421.
- Deschênes-Simard, X., Gaumont-Leclerc, M.F., Bourdeau, V., Moiseeva, O., Forest, V., Ingelman, S., Mallette, F.A., Lessard, F., El-Leil, M.S., Meloche, S., Saad, F., Mes-Masson A.M. and Ferbeyre G. (2013). Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. Genes and Dev 27(8):900-15.
- Vernier M, Bourdeau V, Gaumont-Leclerc MF, Moiseeva O, Bégin V, Saad F, Mes-Masson AM, Ferbeyre G. (2011). Regulation of E2Fs and senescence by PML nuclear bodies. Genes Dev. 25(1):41-50.