Institut de recherches cliniques de Montréal
T 514 987-5776
The research unit Hematopoiesis and Cancer follows the aim to better understand the molecular basis of the physiology, ontogeny and differentiation of all blood cells and to reveal the mechanisms leading to cancer in the hematopoietic system, i.e. to leukemia and lymphoma. We see our work also as a contribution to larger efforts to identify of targets for future therapeutic strategies for hematopoietic neoplasms. Our research programme focuses on the role of transcription factors, chromatin regulators and cytoplasmic kinases such as the zinc finger proteins Gfi1 and Gfi1b, the POZ/BTB transcription factor Miz-1 and the serine/threonine kinase Pim-1. As a general approach to understand their function, we generate mutant alleles by gene targeting in the mouse; an extremely powerful method that has allowed us to gain deeper insight into a number of critical steps in stem cell self-renewal and hematopoietic differentiation.
- Khandanpour C, Phelan JD, Vassen L, Schütte J, Chen R, Horman S, Gaudreau MC, Krongold J, Zhu J, Paul WE, Dührsen U, Göttgens B, Grimes HL and Möröy T. Growth factor independence 1 (Gfi1) antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia. Cancer Cell, 2013, Feb 11;23:200-214.
- Khandanpour C, Kosan C, Gaudreau MC, Dührsen U, Zeng H and Möröy T. Growth factor independence 1 (Gfi1) protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease. Stem Cells, 2011 Feb 24;29:376–385.
- Kosan C, Saba I, Godmann M, Herold S, Herkert B, Eilers M and Möröy T. The BTB/POZ domain protein Miz-1 (Zbtb17) is required to regulate IL-7 receptor signaling at early commitment stages of B cell differentiation. Immunity, 2010, Dec 14;33(6):917-28.