Julie Lavoie

Accredited Professor

Contact Information

Centre de recherche
CHUM – Technopôle Angus
2901, rue Rachel Est, bureau 310
Montréal (Québec)
H1W 4A4


T 514 890-8000, poste 23612
T 514 343-5602
F 514 412-7655


Preeclampsia animal models and impact of exercise training

  • This project studies preeclampsia, a pregnancy-associated disease in which women develop hypertension and proteinuria, and the effect of exercise training on the pathology in animal models. Furthermore, we wish to investigate the mechanisms by which exercise training can prevent the disease.

Adipose renin-angiotensin system and obesity and obesity-related disease

  • We wish to investigate the implication of the local renin-angiotensin system (RAS) in adipose tissue on obesity and obesity-related diseases such as hypertension and diabetes. For instance, we will evaluate the involvement of the renin receptor in the development of obesity and its related symptoms as well as investigate the potential therapeutic value of the renin receptor blocker for the treatment of obesity and the metabolic syndrome. Also, with the use of novel transgenic mice, we plan to determine which RAS inhibitor, when comparing renin and angiotensin converting-enzyme inhibitors as well as angiotensin receptor blockers, may be more effective for the treatment of hypertension-related to obesity as these individuals are presently difficult to treat.


  • Lavoie, J.L., Liu, X., Bianco, R.A., Beltz, T.G., Johnson, A.K. and Sigmund, C.D.  Evidence supporting a functional role for intracellular renin in the brain.  Hypertension 47(3):461-6, 2006.
  • Lavoie, J.L.  Normal circulating renin-angiotensin system but hypertensive: are the local systems the culprit?  Hypertension Canada 89:4-8, 2006.
  • Lavoie, J.L.   Pression artérielle chez la souris avec un nouveau transmetteur miniaturisé. S.T.A.L. 31(3/4):1-3, 2006.
  • Lazartigues, E., Feng, Y. and Lavoie, J.L. The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases. Current Pharmaceutical Design 13(12):1231-45, 2007.
  • Falcao, S., *Bisotto, S., Gutkowska, J., and Lavoie, J.L. Hyperhomocysteinemia is not sufficient to cause preeclampsia in an animal model: the importance of folate intake. Am. J. Obst. Gynecol. 200(2):198.e1-5, 2009.
  • Falcao, S., Solomon, C., Monat, C., *Bérubé, J., Gutkowska, J. and Lavoie, J.L. Impact of diet and stress on the development of preeclampsia-like symptoms in p57kip2 mice. Am. J. Physiol. (Heart and Circ. Physiol.) 296(1):H119-26, 2009.
  • Falcao, S., Stoyanova, E., Cloutier, G., Maurice, R.L. Gutkowska, J. and Lavoie, J.L. Mice overexpressing both human angiotensinogen and human renin as a model of Superimposed preeclampsia on Chronic Hypertension.  Hypertension 54(6):1401-7, 2009.
  • Falcao, S., *Bisotto, S., *Michel, C., Lacasse, A.-A., Vaillancourt, C., Gutkowska, J. and Lavoie, J.L. Exercise training can reduce PE-like symptoms in an animal model. J. of Hypertension 28(12):2446-2453, 2010.
  • Lavoie, J.L. and Gutkowska, J. Can exercise prevent preeclampsia?: author’s reply. J. of Hypertension. 29(7):1465, 2011.
  • Ahmed, B.A. Seda, O. and Lavoie, J.L. (Pro)Renin receptor as a new drug target. Curr. Pharm. Des. 17(33): 3611-21, 2011.