Centre de recherche
My lab studies how genetic variation predisposes individuals to develop cardiovascular (e.g. myocardial infarction) and hematological (e.g. sickle cell disease) diseases, or how the same genetic variation modulates disease severity. We use modern genetic and genomic approaches, such as genome-wide association studies and next-generation DNA re-sequencing, to identify genetic risk factors for these diseases. Projects in the lab could involve: (1) analyzing complex genetic datasets, (2) developing new algorithm for data mining and integration, and (3) molecular and cellular functional validation of new genetic discoveries. For more information, please visit our website.
- Michael N. Weedon*, Guillaume Lettre*, Rachel M. Freathy*, Cecilia M. Lindgren*, et al. A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet. 2007 Oct;39(10):1245-1250.
- Guillaume Lettre, Anne U. Jackson, Christian Gieger, Fredrick R. Schumacher, Sonja I. Berndt, Serena Sanna, Susana Eyheramendy, Benjamin F Voight, Johannah L. Butler, Candace Guiducci, et al. Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet. 2008 May;40(5):584-91.
- Guillaume Lettre*, Vijay G. Sankaran*, Marcos André C. Bezerra, Aderson S. Araújo, Manuela Uda, Serena Sanna, Antonio Cao, Fernando F. Costa, Joel N. Hirschhorn, and Stuart H. Orkin. DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin and pain crises in sickle cell disease. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11869-74.
- Kiran Musunuru*, Guillaume Lettre*, Taylor Young*, Deborah N. Farlow*, James P. Pirruccello, Kenechi G. Ejebe, Qiong Yang, Ming-Huei Chen, Nina Lapchyk, Andrew Crenshaw, et al. Candidate Gene Association Resource (CARe): Design, Methods, and Proof of Concept. Circ Cardiovascular Genet 2010 April 17.