Daniel Lajeunesse

Accredited Professor

Contact Information

Centre de Recherche du CHUM
Hôpital Notre-Dame
Pavillon JA DeSève, bureau Y-2603
1560, est rue Sherbrooke
Montréal (Québec)
H2L 4M1

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T 514 890-8000, poste 28914 (bureau)
T 514 890-8000, poste 28907 (laboratoire)
F 514 412-7583
daniel.lajeunesse@umontreal.ca

Themes

  • Osteoarthrose
  • Osseous mineralization
  • Wnt signalisation
  • Growth factors
  • Leptin
  1. Role of subchondral bone in the pathogenesis of osteoarthrosis (OA).  Implication of IGF-1, HGF and TGF-beta 1 signaling pathways in OA osteoblasts.
  2. Role of the extracellular matrix (ECM) and in particular collagen type 1 in OA bone sclerosis and abnormal mineralization.  Role of eicosanoids in OA bone sclerosis.
  3. Role of endogenous leptin production by OA osteoblasts in pathogenesis of OA and abnormal mineralisation.
  4. Implication of the Wnt signaling pathway in OA pathogenesis:  role of Dicckpof (DKK) and sclerostin (SOST) in abnormal signalisation in OA osteoblasts.

Publications

  • *Massicotte, F., Martel-Pelletier, J., Pelletier, J.-P., & Lajeunesse, D. : Modulation of Insulin-like Growth Factor 1 levels in human osteoarthritic subchondral bone osteoblasts.  Bone 38, 333-341, 2006.
  • Martel-Pelletier, J., Lajeunesse, D., Fahmi, H., Tardif, G., Pelletier, J.-P. : New thoughts on the pathophysiology of osteoarthritis: one more step toward new therapeutic targets.  Current Rheumatology Reports. 8(1):30-6, 2006 (selected by the editor for reproduction in Curr. Primary Care Rep. 2:3-9, 2007).
  • *Massicotte, F., Aubry, I., Martel-Pelletier, J., Pelletier, J.-P. & Lajeunesse, D.: Abnormal Insulin-like Growth Factor-1 intracellular signaling in human osteoarthritic osteoblasts. Arthritis Res Ther. 2006;8(6):R177.
  • *Maxis, K., Delalandre, A., Sabouret, P. & Lajeunesse, D.: Variable production of leukotriene B4 in human osteoarthritic subchondral osteoblasts is due to altered expression of 5-lipoxygenase activating protein. Arthritis Res Ther. 2006;8(6):R181.
  • *Tat, S.K., Pelletier, J.-P., Verges, J., Lajeunesse, D., Montell, E., Fahmi, H., Lavigne, M. & Martel-Pelletier, J. : Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: A basic science study. Arthritis Res Ther. 2007;9:R117.
  • *Tat, S.K., Pelletier, J.-P., Lajeunesse, D., Fahmi, H., Lavigne, M., & Martel-Pelletier, J. : The Differential Expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kB ligand (RANKL) in Human Osteoarthritic Subchondral Bone Osteoblasts is an Indicator of the Metabolic State of These Diseased Cells. Clin. Expr. Rheum. 2008;26(2):295-304.
  • *Tat, S.K., Pelletier, J.-P., Lajeunesse, D., Fahmi, H., Duval, N. & Martel-Pelletier, J. Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts:  Influence of osteotropic factors.  Bone 2008 (in press)
  • Fernandes, J.C., SHI, Q., Benderdour, M., Lajeunesse, D. & *Lavigne, P.:  An active role for soluble and membrane intercellular adhesion molecule-1 on osteoclast activity in vitro.  Journal Bone Mineral Metabolism (In press) 2008
  • Kwan Tat S., Pelletier J-P., Lajeunesse D., Duval N. et Martel-Pelletier J.: Activation of EphB4 receptor by its ligand EphB2 in human osteoarthritic subchondral bone osteoblasts  ostéoblastes.  Arthritis & Rheum. 2008 (in press)