Dr. Dr Bouvier’s team is composed of professional research coordinators, post-doctoral fellows, graduate students and research assistants. The research program focuses on the molecular mechanisms controlling the function of the largest family of drug targets, the G protein-coupled receptors (GPCR). Using a combination of biochemical, molecular and cell biology and biophysical methods the projects aimed at studying the dynamics of the protein-protein interactions involved in GPCR-mediated signal propagation. Dissecting the molecular basis underlying signalling selectivity and efficacy of GPCR has direct implication for the development of innovative approaches for the discovery of new drugs.
- Breton B, Sauvageau É, Zhou J, Bonin H, Le Gouill C & Bouvier M. (2010) Multiplexing of multicolor bioluminescence resonance energy transfer. J., 99(12):4037-4046
- Quoyer J, Janz JM, Luo J, Ren Y, Armando S, Lukashova V, Benovic JL, Carlson KE, Hunt SW & Bouvier M. (2013). Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc Natl Acad Sci USA. 110(52):5088-97.
- Armando S, Quoyer J, Lukashova V, Maiga A, Percherancier Y, Heveker N, Pin JP, Prézeau L, Bouvier M. (2014). The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and β FASEB J. 28(10):4509-4523.
- Sauvageau, E., Rochdi, D.M., Oueslati, M., Hamdan, F.H., Percherancier, Y., Simpson, J.C., Pepperkok, R., and Bouvier, M. (2014). CNIH4 interacts with newly synthesized GPCR and control their export form the endoplasmic reticulum. Traffic, 15(4):383-400.
- Paradis, J., Roux, P. and Bouvier, M. (2015). Receptor sequestration in response to barrestin-2 phosphorylation governs steady-state levels of GPCR cell surface expression. Proc Natl Acad Sci USA. 112(37):E5160-8
A complete list of publication: can be found at: