Frédérick Antoine Mallette
Centre de Recherche
5415, boul. de l’Assomption
T 514 252-3400, poste 3341 bureau
T 514 252-3400, poste 3338 labo
F 514 252-3430
Normal cells possess intrinsic mechanisms to avoid genetic mutations that contribute to the formation of cancer. One of these mechanisms is cellular senescence, defined as a permanent cell cycle arrest where the cell remains metabolically active but no longer capable to respond to proliferation stimuli. Methylation of histones plays an important role during senescence by contributing to the stable repression of genes involved in cell cycle progression.
The focus of my research program is to examine the biological role of histone demethylases in different cellular processes including cell cycle, gene regulation, DNA damage response and tumorigenesis. The long-term objective will be to provide a better understanding of the role epigenetic modifications in cancer leading to the development of potential therapeutics in the treatment of cancer.