Les chercheurs, distinctions et publications

Nos chercheurs

Les trente-deux professeurs et quatre professeurs de clinique du Département dirigent des programmes de recherche à la fine pointe de la biochimie et de la bio-informatique. De plus, quarante professeurs accrédités ou associés, oeuvrant dans différents centres ou instituts de recherche (BRI, CR-CHUM, HMR, ICM, IRCM, IRIC, Ste-Justine), participent à la formation d’étudiants aux cycles supérieurs du Département et contribuent à une plus grande diversification de la recherche et de l’enseignement.

Avec plus de 200 étudiants aux cycles supérieurs, des stagiaires postdoctoraux et professionnels de la recherche, ils mènent des activités de recherche regroupées selon 5 axes de recherche qui portent sur les mécanismes fondamentaux de la vie et les fondements moléculaires de la médecine.

Prix et distinctions

Promotion/nomination

Nous sommes heureux d’annoncer la titularisation de Nathalie Grandvaux, effectif le premier juin 2017. Mme Grandvaux dont les laboratoires sont situés au Centre de recherche du CHUM s’intéresse aux mécanismes de défense antiviraux, notamment à l’immunité innée et à l’inflammation.

Nous félicitons Karim Benkirane pour sa nomination en tant que professeur-adjoint de clinique. Monsieur Benkirane est un biochimiste clinique qui travaille à l’Hôpital Maisonneuve-Rosemont.

Prix Julius Axelrod

Michel Bouvier a été récompensé pour ses contributions à titre de scientifique et de mentor par le prix Julius Axelrod en pharmacologie 2017. Ce prix est octroyé par l’American Society for Pharmacology and Experimental Therapeutics.

Publications 2017

Félicitations aux groupes de recherche pour leurs publications!

Publications – Chroniques biochimiques 3e édition

Lecoq L, Raiola L, Chabot PR, Cyr N, Arseneault G, Legault P, Omichinski JG. Structural characterization of interactions between transactivation domain 1 of the p65 subunit of NF-κB and transcription regulatory factors. Nucleic Acids Res. 2017.

Langelier MF, Steffen JD, Riccio AA, McCauley M, Pascal JM. Purification of DNA Damage-Dependent PARPs from E. coli for Structural and Biochemical Analysis. Methods Mol Biol. 2017;1608:431-444.

Sultanov DC, Gerasimova NS, Kudryashova KS, Maluchenko NV, Kotova EY, Langelier MF, Pascal JM, Kirpichnikov MP, Feofanov AV, Studitsky VM. Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy. AIMS Genet. 2017;4(1):21-31.

Tavormina PL, Kellermann MY, Antony CP, Tocheva EI, Dalleska NF, Jensen AJ, Valentine DL, Hinrichs KU, Jensen GJ, Dubilier N, Orphan VJ. Starvation and recovery in the deep-sea methanotroph Methyloprofundus sedimenti. Mol Microbiol. 2017 Jan;103(2):242-252.

Perreault S, de Denus S, White M, White-Guay B, Bouvier M, Dorais M, Dubé MP, Rouleau JL, Tardif JC, Jenna S, Haibe-Kains B, Leduc R, Deblois D. Older adults with heart failure treated with carvedilol, bisoprolol, or metoprolol tartrate: risk of mortality.

Pharmacoepidemiol Drug Saf. 2017 Jan; 26(1):81-90.

Krahn N, Spearman M, Meier M, Dorion-Thibaudeau J, McDougall M, Patel TR, De Crescenzo G, Durocher Y, Stetefeld J, Butler M. Inhibition of glycosylation on a camelid antibody uniquely affects its FcγRI binding activity. Eur J Pharm Sci. 2017 Jan 1; 96:428-439.

Smart J, Fouillen A, Casu B, Nanci A, Baron C. Cag-delta (Cag3) protein from the Helicobacter pylori 26695 cag type IV secretion system forms ring-like supramolecular assemblies.FEMS Microbiol Lett. 2017 Jan; 364(1).

Wong PC, Seiffert D, Bird JE, Watson CA, Bostwick JS, Giancarli M, Allegretto N, Hua J, Harden D, Guay J, Callejo M, Miller MM, Lawrence RM, Banville J, Guy J, Maxwell BD, Priestley ES, Marinier A, Wexler RR, Bouvier M, Gordon DA, Schumacher WA, Yang J. Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.Sci Transl Med. 2017 Jan 4;9(371).

Benredjem B, Girard M, Rhainds D, St-Onge G, Heveker N. Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12. J Biol Chem. 2017 Jan 6;292(1):31-42.

Yousef EM, Furrer D, Laperriere DL, Tahir MR, Mader S, Diorio C, Gaboury LA. MCM2: An alternative to Ki-67 for measuring breast cancer cell proliferation. Mod Pathol 2017 Jan 13.

Wahba HM, Stevenson MJ, Mansour A, Sygusch J, Wilcox DE, Omichinski JG. Structural and biochemical characterization of organotin and organolead compounds binding to the organomercurial lyase MerB provide new insights into its mechanism of carbon-metal bond cleavage.J Am Chem Soc. 2017 Jan 18;139(2):910-921.

Karengera E, Robotham A, Kelly J, Durocher Y, De Crescenzo G, Henry O. Altering the central carbon metabolism of HEK293 cells: Impact on recombinant glycoprotein quality. J Biotechnol. 2017 Jan 20; 242:73-82.

Dorion-Thibaudeau J, Durocher Y, De Crescenzo G. Quantification and simultaneous evaluation of the bioactivity of antibody produced in CHO cell culture-The use of the ectodomain of FcγRI and surface plasmon resonance-based biosensor. Mol Immunol. 2017 Feb;82:46-49.

Fritzius T, Turecek R, Seddik R, Kobayashi H, Tiao J, Rem PD, Metz M, Kralikova M, Bouvier M, Gassmann M, Bettler B. KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABAB Receptor-Induced K+ Currents. J Neurosci. 2017 Feb 1;37(5):1162-1175.

Lefebvre FA, Benoit Bouvrette LP, Bergalet J, Lécuyer E. Biochemical Fractionation of Time-Resolved Drosophila Embryos Reveals Similar Transcriptomic Alterations in Replication Checkpoint and Histone mRNA Processing Mutants. J Mol Biol. 2017 Feb 3.

Gallion J, Koire A, Katsonis P, Schoenegge AM, Bouvier M, Lichtarge O. Predicting phenotype from genotype: improving accuracy through more robust experimental and computational modeling.Hum Mutat. 2017 Feb 23.

Chevrier M, Bobbala D, Villalobos-Hernandez A, Khan MG, Ramanathan S, Saucier C, Ferbeyre G, Geha S, Ilangumaran S. Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer. BMC Cancer. 2017 Feb 24;17(1):157.

Desrochers G, Cappadocia L, Lussier-Price M, Ton AT, Ayoubi R, Serohijos A, Omichinski JG, Angers A. Molecular Basis of Interactions Between SH3 Domain-Containing Proteins and the Proline-Rich Region of the Ubiquitin Ligase Itch.J Biol Chem. 2017 Feb 24.

Sharifahmadian M, Arya T, Bessette B, Lecoq L, Ruediger E, Omichinski JG, Baron C. Monomer-to-dimer transition of Brucella suis type IV secretion system componentVirB8 induces conformational changes.FEBS J. 2017 Feb 25.

Moreau A. The next personalized medicine evolution in orthopedics: how diagnosing and treating scoliosis are about to change. Per Med. 2017 Mar;14(2):89-92.

Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2562-2567.

Stallaert W, van der Westhuizen ET, Schonegge AM, Plouffe B, Hogue M, Lukashova V, Inoue A, Ishida S, Aoki J, Le Gouill C, Bouvier M. Purinergic receptor transactivation by the β2-adrenergic receptor increases intracellular Ca2+ in non-excitable cells. Mol Pharmacol. 2017 Mar 9.

Oliazadeh N, Gorman KF, Eveleigh R, Bourque G, Moreau A. Identification of Elongated Primary Cilia with Impaired Mechanotransduction in Idiopathic Scoliosis Patients. Sci Rep. 2017 Mar 14;7:44260.

Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gandía J, Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, Malty RH, Deineko V, Aoki H, Amin S, Yao Z, Morató X, Otasek D, Kobayashi H, Menendez J, Auerbach D, Angers S, Pržulj N, Bouvier M, Babu M, Ciruela F, Jockers R, Jurisica I, Stagljar I. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Mol Syst Biol. 2017 Mar 15;13(3):918.

Abd-Rabbo D, Michnick SW. Delineating functional principles of the bow tie structure of a kinase-phosphatase network in the budding yeast. BMC Syst Biol. 2017 Mar 16;11(1):38.

Lefebvre FA, Lécuyer E. Small Luggage for a Long Journey: Transfer of Vesicle-Enclosed Small RNA in Interspecies Communication. Front Microbiol. 2017 Mar 16;8:377.

McCormick C, Grandvaux N. 1st Workshop of the Canadian Society for Virology. Viruses. 2017 Mar 20;9(3).

Racki LR, Tocheva EI, Dieterle MG, Sullivan MC, Jensen GJ, Newman DK. Polyphosphate granule biogenesis is temporally and functionally tied to cell cycle exit during starvation in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2440-E2449.

Riahi N, Murschel F, Lerouge S, Durocher Y, Henry O, De Crescenzo G. Bioavailability of immobilized epidermal growth factor: Covalent versus noncovalent grafting. Biointerphases. 2017 Mar 21; 12(1):010501.

Ziarek JJ, Kleist AB, London N, Raveh B, Montpas N, Bonneterre J, St-Onge G, DiCosmo-Ponticello CJ, Koplinski CA, Roy I, Stephens B, Thelen S, Veldkamp CT, Coffman FD, Cohen MC, Dwinell MB, Thelen M, Peterson FC, Heveker N, Volkman BF. Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation. Sci Signal. 2017 Mar 21; 10 (471).

Reimer KA, Stark MR, Aguilar LC, Stark SR, Burke RD, Moore J, Fahlman RP, Yip CK, Kuroiwa H, Oeffinger M, Rader SD. The sole LSm complex in Cyanidioschyzon merolae associates with pre-mRNA splicing and mRNA degradation factors. RNA. 2017 Mar 21.

Möller D, Banerjee A, Uzuneser TC, Skultety M, Huth T, Plouffe B, Hübner H, Alzheimer C, Friedland K, Müller CP, Bouvier M, Gmeiner P. Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure. J Med Chem. 2017 Mar 22.

Madadkar P, Umatheva U, Hale G, Durocher Y, Ghosh R. Ultra-fast separation and analysis of monoclonal antibody aggregates using membrane chromatography. Anal Chem. 2017 Mar 27.

Guinoiseau T, Moreau A, Hohnadel G, Ngo-Giang-Huong N, Brulard C, Vourc’h P, Goudeau A, Gaudy-Graffin C. Deep sequencing is an appropriate tool for the selection of unique Hepatitis C virus (HCV) variants after single genomic amplification. PLoS One. 2017 Mar 31;12 (3):e0174852.

Ramachandran R, Mihara K, Thibeault P, Vanderboor CM, Petri B, Saifeddine M, Bouvier M, Hollenberg MD.Targeting a PAR4 carboxyl terminal motif to regulate platelet function. Mol Pharmacol. 2017 Apr; 91(4):287-295.

Gougain M, Moreau A, Boussageon R, Pickering G, Gueyffier F. Acute analgesic effect of paracetamol in primary care: Incomplete evidence. Therapie. 2017 Apr 4. pii: S0040-5957(17)30057-4.

Dagenais P, Girard N, Bonneau E, Legault P. Insights into RNA structure and dynamics from recent NMR and X-ray studies of the Neurospora Varkud satellite ribozyme. Wiley Interdiscip Rev RNA. 2017 Apr 6. doi: 10.1002/wrna.1421.

Rahman S, Zorca CE, Traboulsi T, Noutahi E, Krause MR, Mader S, Zenklusen D. Single-cell profiling reveals that eRNA accumulation at enhancer-promoter loops is not required to sustain transcription. Nucleic Acids Res. 2017 Apr 7;45(6):3017-3030.

Oudouhou F, Casu B, Dopgwa Puemi AS, Sygusch J, Baron C. Analysis of novel interactions between components of the selenocysteine biosynthesis pathway SEPHS1, SEPHS2, SEPSECS and SECp43. Biochemistry. 2017 Apr 17. doi: 10.1021/acs.biochem.6b01116.

Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich FM, Khoury E, Audet M, Roux PP, Veprintsev DB, Laporte SA, Bouvier M. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017 Apr 18; 8:15054.

Kelil A, Dubreuil B, Levy ED, Michnick SW. Exhaustive search of linear information encoding protein-peptide recognition. PLoS Comput Biol. 2017 Apr 20;13(4):e1005499.

Fouillen A, Dos Santos Neves J, Mary C, Castonguay JD, Moffatt P, Baron C, Nanci A. Interactions of AMTN, ODAM and SCPPPQ1 proteins of a specialized basal lamina that attaches epithelial cells to tooth mineral. Sci Rep. 2017 Apr 24; 7: 46683.

Madadkar P, Sadavarte R, Butler M, Durocher Y, Ghosh R. Preparative separation of monoclonal antibody aggregates by cation-exchange laterally-fed membrane chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Apr 25;1055-1056:158-164.

Lalonde ME, Durocher Y. Therapeutic glycoprotein production in mammalian cells. J Biotechnol. 2017 Apr 29. pii: S0168-1656(17)30191-8.

Sakaguchi T, Janairo JIB, Lussier-Price M, Wada J, Omichinski JG, Sakaguchi K. Oligomerization enhances the binding affinity of a silver biomineralization peptide and catalyzes nanostructure formation. Sci Rep. 2017 May 3;7(1):1400.

Lemieux S, Sargeant T, Laperrière D, Ismail H, Boucher G, Rozendaal M, Lavallée VP, Ashton-Beaucage D, Wilhelm B, Hébert J, Hilton DJ, Mader S, Sauvageau G. MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets. Nucleic Acids Res. 2017 May 4. doi: 10.1093/nar/gkx338.

Archambault V, Normandin K. Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators. Cell Cycle. 2017 May 19:0. doi: 10.1080/15384101.2017.1325043.

Villiard É, Denis JF, Hashemi FS, Igelmann S, Ferbeyre G, Roy S. Senescence gives insights into the morphogenetic evolution of anamniotes. Biol Open. 2017 May 12. pii: bio.025809.

Lefebvre FA, Bouvrette LPB, Bergalet J, Lécuyer E. Data for the generation of RNA spatiotemporal distributions and interpretation of Chk1 and SLBP protein depletion phenotypes during Drosophila embryogenesis. Data Brief. 2017 May 13;13:28-31.

Hernández-Ramírez LC, Gam R, Valdés N, Lodish M, Pankratz N, Balsalobre A, Gauthier Y, Faucz FR, Trivellin G, Chittiboina P, Lane J, Kay DM, Dimopoulou A, Gaillard S, Neou M, Bertherat J, Assié G, Villa C, Mills JL, Drouin J, Stratakis CA. Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing’s disease. Endocr Relat Cancer. 2017 May 22. pii: ERC-17-0131.

Williams V, Grosset AA, Zamorano Cuervo N, St-Pierre Y , Sylvestre MP, Gaboury L, Grandvaux N. Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis. BMC Cancer. 2017 May 22;17(1):356.

Cloutier P, Poitras C, Durand M, Hekmat O, Fiola-Masson É, Bouchard A, Faubert D, Chabot B, Coulombe B. R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein. Nat Commun. 2017 May 31;8:15615.

Lefebvre FA, Cody N, Bouvrette LPB, Bergalet J, Wang X, Lécuyer E. CeFra-seq: Systematic mapping of RNA subcellular distribution properties through cell fractionation coupled to deep-sequencing. Methods. 2017 Jun 1. pii: S1046-2023(16)30406-6.

Reimer KA, Stark MR, Aguilar LC, Stark SR, Burke RD, Moore J, Fahlman RP, Yip CK, Kuroiwa H, Oeffinger M, Rader SD. The sole LSm complex in Cyanidioschyzon merolae associates with pre-mRNA splicing and mRNA degradation factors. RNA. 2017 Jun;23(6):952-967.

Milek M, Imami K, Mukherjee N, De Bortoli F, Zinnall U, Hazapis O, Trahan C, Oeffinger M, Heyd F, Ohler U, Selbach M, Landthaler M. DDX54 regulates transcriptome dynamics during DNA damage response. Genome Res. 2017 Jun 8.

Normand E, Franco A, Moreau A, Marcil V. Dipeptidyl Peptidase-4 and Adolescent Idiopathic Scoliosis: Expression in Osteoblasts. Sci Rep. 2017 Jun 9;7(1):3173.

Nada D, Julien C, Samuels ME, Moreau A. A Replication Study for Association of LBX1 locus with Adolescent Idiopathic Scoliosis in French-Canadian Population. Spine (Phila Pa 1976). 2017 Jun 9. doi: 10.1097/BRS.0000000000002280.

Dobro MJ, Oikonomou CM, Piper A, Cohen J, Guo K, Jensen T, Tadayon J, Donermeyer J, Park Y, Solis BA, Kjær A, Jewett AI, McDowall AW, Chen S, Chang YW, Shi J, Subramanian P, Iancu CV, Li Z, Briegel A, Tocheva EI, Pilhofer M, Jensen GJ. Uncharacterized bacterial structures revealed by electron cryotomography. J Bacteriol. 2017 Jun 12. pii: JB.00100-17.

Poulain A, Perret S, Malenfant F, Mullick A, Massie B, Durocher Y. Rapid protein production from stable CHO cell pools using plasmid vector and the cumate gene-switch. J Biotechnol. 2017 Jun 15. pii: S0168-1656(17)30290-0.

Chin A, Lécuyer E. RNA Localization: Making its Way to the Center Stage. Biochim Biophys Acta. 2017 Jun 16. pii: S0304-4165(17)30197-6.

Ouenzar F, Lalonde M, Laprade H, Morin G, Gallardo F, Tremblay-Belzile S, Chartrand P. Cell cycle-dependent spatial segregation of telomerase from sites of DNA damage. J Cell Biol. 2017 Jun 21. pii: jcb.201610071.

Ferbeyre G. Aberrant signaling and senescence associated protein degradation. Exp Gerontol. 2017 Jun 25. pii: S0531-5565(17)30219-X.

Diot C, Chin A, Lécuyer E. Optimized FISH methods for visualizing RNA localization properties in Drosophila and human tissues and cultured cells. Methods. 2017 Jun 28. pii: S1046-2023(17)30089-0.

Manceur AP, Zou W, Marcil A, Paquet E, Gadoury C, Jaentschke B,Li X, Petiot E, Durocher Y, Baardsnes J, Rosa-Calatrava M, Ansorge S, Kamen AA. Generation of monoclonal pan-hemagglutinin antibodies for the quantification of multiple strains of influenza. PLoS One. 2017 Jun 29;12(6):e0180314.

Chand SN, Zarei M, Schiewer MJ, Kamath AR, Romeo C, Lal S, Cozzitorto JA, Nevler A, Scolaro L, Londin E, Jiang W, Meisner-Kober N, Pishvaian MJ, Knudsen KE, Yeo CJ, Pascal JM, Winter JM, Brody JR. Post-transcriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors. Cancer Res. 2017 Jul 7. pii: canres.2704.2016.

Querido E, Dekakra-Bellili L, Chartrand P. RNA fluorescence in situ hybridization for High-Content Screening. Methods. 2017 Jul 7. pii: S1046-2023(16)30421-2.

Beaujois R, Ottoni E, Zhang X, Gagnon C, HSine S, Mollet S, Viranaicken W, DesGroseillers L. The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1. BMC Cell Biol. 2017 Jul 14;18(1):25.

Vivcharuk V, Baardsnes J, Deprez C, Sulea T, Jaramillo M, Corbeil CR, Mullick A, Magoon J, Marcil A, Durocher Y, O’Connor-McCourt MD, Purisima EO. Assisted Design of Antibody and Protein Therapeutics (ADAPT). PLoS One. 2017 Jul 27;12(7):e0181490.

Sharifahmadian M, Nlend IU, Lecoq L, Omichinski JG, Baron C. The type IV secretion system core component VirB8 interacts via the β1-strand with VirB10. FEBS Lett. 2017 Aug 2.; 591(16):2491-2500.

Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P. HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms. JCI Insight. 2017 Aug 3;2(15).

Parreiras-E-Silva LT, Vargas-Pinilla P, Duarte DA, Longo D, Espinoza Pardo GV, Dulor Finkler A, Paixão-Côrtes VR, Paré P, Rovaris DL, Oliveira EB, Caceres RA, Gonçalves GL, Bouvier M, Salzano FM, Lucion AB, Costa-Neto CM, Bortolini MC. Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats. Proc Natl Acad Sci U S A. 2017 Aug 7. pii: 201711687.

Henry KA, Kandalaft H, Lowden MJ, Rossotti MA, van Faassen H, Hussack G, Durocher Y, Kim DY, Tanha J. A disulfide-stabilized human VL single-domain antibody library is a source of soluble and highly thermostable binders. Mol Immunol. 2017 Aug 15;90:190-196.

Stefic K, Chaillon A, Bouvin-Pley M, Moreau A, Braibant M, Bastides F, Gras G, Bernard L, Barin F. Probing the compartmentalization of HIV-1 in the central nervous system through its neutralization properties. PLoS One. 2017 Aug 25; 12(8):e0181680.

Vakiloroayaei A, Shah NS, Oeffinger M, Bayfield MA. The RNA chaperone La promotes pre-tRNA maturation via indiscriminate binding of both native and misfolded targets. Nucleic Acids Res. 2017 Aug 31. doi: 10.1093/nar/gkx764.

Nemec S, Luxey M, Jain D, Huang Sung A, Pastinen T, Drouin J. Pitx1 directly modulates the core limb development program to implement hindlimb identity. Development. 2017 Sep 15;144(18):3325-3335.

Teixeira LB, Parreiras-E-Silva LT, Bruder-Nascimento T, Duarte DA, Simões SC, Costa RM, Rodríguez DY, Ferreira PAB, Silva CAA, Abrao EP, Oliveira EB, Bouvier M, Tostes RC, Costa-Neto CM. Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy. Sci Rep. 2017 Sep 19;7(1):11903.

Heron PW, Sygusch J. Isomer Activation Controls Stereospecificity of Class I Fructose-1,6-bisphosphate Aldolases. J Biol Chem. 2017 Sep 27. pii: jbc.M117.811034.

King BR, Kellner S, Eisenhauer PL, Bruce EA, Ziegler CM, Zenklusen D, Botten JW. Visualization of the lymphocytic choriomeningitis mammarenavirus (LCMV) genome reveals the early endosome as a possible site for genome replication and viral particle pre-assembly. J Gen Virol. 2017 Sep 27. doi: 10.1099/jgv.0.000930.

Burlacu E, Lackmann F, Aguilar LC, Belikov S, Nues RV, Trahan C, Hector RD, Dominelli-Whiteley N, Cockroft SL, Wieslander L, Oeffinger M, Granneman S. High-throughput RNA structure probing reveals critical folding events during early 60S ribosome assembly in yeast. Nat Commun. 2017 Sep 28;8(1):714.