{"id":7198,"date":"2014-06-09T15:20:47","date_gmt":"2014-06-09T14:20:47","guid":{"rendered":"http:\/\/biochimie.umontreal.ca\/?page_id=7198"},"modified":"2017-06-19T14:52:27","modified_gmt":"2017-06-19T18:52:27","slug":"nicolas-bousette","status":"publish","type":"page","link":"https:\/\/biochimie.umontreal.ca\/en\/department\/nicolas-bousette\/","title":{"rendered":"Nicolas Bousette"},"content":{"rendered":"

Professeur accr\u00e9dit\u00e9<\/h2>\n\n\n\n
\"\"<\/td>\n\n

Coordonn\u00e9es<\/h2>\n

Institut de Cardiologie de Montr\u00e9al
\n5000, rue B\u00e9langer, suite S-4100
\nMontr\u00e9al (Qu\u00e9bec)
\nH1T 1C8<\/td>\n

\n

.<\/span><\/h2>\n

T<\/strong> 514 376-3330, poste 3403
\nT<\/strong> 514 376-3330, poste 3017 labo
\nF<\/strong> 514 376-1355
\nnicolas.bousette@umontreal.ca<\/a>
\nSite web<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\n

Th\u00e8mes<\/h2>\n
Notre laboratoire se concentre sur la poursuite de notre compr\u00e9hension des \u00e9v\u00e9nements cl\u00e9s de l’incitation lipotoxicit\u00e9 cardiaque et comment ils conduisent \u00e0 la progression de la cardiomyopathie diab\u00e9tique. C\u2019est \u00e0 dire, quels sont les facteurs qui d\u00e9clenchent lipotoxicit\u00e9 cardiaque et comment se<\/div>\n
traduisent-ils dans la progression de la maladie? La cardiomyopathie diab\u00e9tique est de plus en plus<\/div>\n
reconnue comme une maladie inflammatoire qui est associ\u00e9e \u00e0 une diminution de l’utilisation du glucose et une augmentation concomitante de l’absorption d’acide gras. Ce d\u00e9rangement m\u00e9tabolique r\u00e9sulte m\u00eame en un plus grand rapport de l’ATP d\u00e9riv\u00e9 d\u2019acides gras contre le glucose que normale.<\/div>\n
Malgr\u00e9 cette augmentation d\u2019oxydation accrue des acides gras, des c\u0153urs diab\u00e9tiques accumulent encore des exc\u00e8s de lipides intracellulaires et cela se produit avant le d\u00e9veloppement de dysfonction.<\/div>\n
Cela sugg\u00e8re qu’il existe un degr\u00e9 de \u03b2 -oxydation insuffisante pour r\u00e9pondre \u00e0 l’augmentation de l’absorption d’acide gras qui se produit dans les c\u0153urs diab\u00e9tiques. Ici, nous proposons que les m\u00e9diateurs inflammatoires nuisent \u00e0 la \u03b2-oxydation mitochondriale dans le c\u0153ur diab\u00e9tique qui cause une aggravation d\u2019accumulation des lipides. Avec le temps cette inad\u00e9quation entre l’absorption et la \u03b2-oxydation dans les c\u0153urs diab\u00e9tiques provoque la progression de la st\u00e9atose cardiaque, qui \u00e0 son tour favorise davantage la lipotoxicit\u00e9 et \u00e9ventuellement la cardiomyopathie diab\u00e9tique.<\/div>\n
En effet, des \u00e9tudes cliniques ont montr\u00e9 une corr\u00e9lation entre le degr\u00e9 d’accumulation des lipides et un dysfonctionnement cardiaque chez les patients diab\u00e9tiques. Nous avons montr\u00e9 que les cytokines r\u00e9duisent \u00e0 la fois l’activit\u00e9 et l’expression de r\u00e9gulateurs m\u00e9taboliques cl\u00e9s et des enzymes impliqu\u00e9s dans la \u03b2-oxydation et perp\u00e9tuent ainsi l’accumulation de lipides. Cela conduit \u00e0 un cercle vicieux de l’inflammation et lipotoxicit\u00e9 aboutissant \u00e0 la perte de cardiomyocytes, la dysfonction cardiaque et en<\/div>\n
fin de compte, l’insuffisance cardiaque. Nous utilisons les derni\u00e8res techniques et technologies pour<\/div>\n
approfondir notre compr\u00e9hension de ces m\u00e9canismes pathologiques dans des mod\u00e8les de cardiomyopathie diab\u00e9tique (in vitro et in vivo).<\/div>\n
En fin de compte, nous visons \u00e0 \u00e9tablir des modalit\u00e9s th\u00e9rapeutiques avec des avantages cliniques am\u00e9lior\u00e9s.<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Publications<\/h3>\n
    \n
  • Haffar, T., Berube-Simard, F.A., Tardif, J.-C. & Bousette, N. Saturated fatty acidsinduce endoplasmic reticulum stress in primary cardiomyocytes. Endoplasm.Reticul. Stress Dis. , 53-66 (2015).<\/li>\n
  • Haffar, T., Berube-Simard, F.A. & Bousette, N. Cardiomyocyte lipotoxicity ismediated by Il-6 and causes down-regulation of PPARs. Biochemical andbiophysical research communications (2015).<\/li>\n
  • Bousette, N., Abbasi, C., Chis, R. & Gramolini, A.O. Calnexin silencing in mouseneonatal cardiomyocytes induces Ca2+ cycling defects, ER stress, and apoptosis.Journal of cellular physiology 229, 374-383 (2014).<\/li>\n
  • Bousette, N. et al. Constitutively active calcineurin induces cardiac endoplasmicreticulum stress and protects against apoptosis that is mediated by alphacrystallin-B. Proceedings of the National Academy of Sciences of the UnitedStates of America 107, 18481-18486 (2010).<\/li>\n
  • Bousette, N. et al. Urotensin II receptor knockout mice on an ApoE knockoutbackground fed a high-fat diet exhibit an enhanced hyperlipidemic andatherosclerotic phenotype. Circulation research 105, 686-695, 619 p following695 (2009).<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    Professeur accr\u00e9dit\u00e9 Coordonn\u00e9es Institut de Cardiologie de Montr\u00e9al 5000, rue B\u00e9langer, suite S-4100 Montr\u00e9al (Qu\u00e9bec) H1T 1C8 . T 514 376-3330, poste 3403 T 514 376-3330, poste 3017 labo F […]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":11439,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7198","page","type-page","status-publish","hentry"],"yoast_head":"\nNicolas Bousette - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biochimie.umontreal.ca\/en\/department\/nicolas-bousette\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nicolas Bousette - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Professeur accr\u00e9dit\u00e9 Coordonn\u00e9es Institut de Cardiologie de Montr\u00e9al 5000, rue B\u00e9langer, suite S-4100 Montr\u00e9al (Qu\u00e9bec) H1T 1C8 . 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