{"id":687,"date":"2012-06-19T10:53:32","date_gmt":"2012-06-19T09:53:32","guid":{"rendered":"http:\/\/biochimie.umontreal.ca\/?page_id=687"},"modified":"2016-11-08T15:11:04","modified_gmt":"2016-11-08T20:11:04","slug":"lea-brakier-gingras","status":"publish","type":"page","link":"https:\/\/biochimie.umontreal.ca\/en\/department\/lea-brakier-gingras\/","title":{"rendered":"L\u00e9a Brakier-Gingras"},"content":{"rendered":"

Professor<\/h2>\n\n\n\n
\"\"<\/td>\n\n

Contact Information<\/h2>\n

D\u00e9partement de biochimie
\nFacult\u00e9 de M\u00e9decine
\nUniversit\u00e9 de Montr\u00e9al
\nPavillon Roger-Gaudry, bureau E-519
\nC.P. 6128, Succ. Centre-ville
\nMontr\u00e9al (Qu\u00e9bec)
\nH3C 3J7<\/td>\n

\n

.<\/span><\/h2>\n

T<\/strong> 514 343-6316
\n<\/strong>F<\/strong> 514 343-2210
\nlea.brakier.gingras@umontreal.ca<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\n

Themes<\/h2>\n
    \n
  • Gene expression control<\/li>\n<\/ul>\n

    Changes in the fidelity of translation in senescent cells<\/strong><\/p>\n

    Senescence is a permanent arrest of the replication cycle that opposes to the proliferation of cancerous cells and is also involved in the process of aging. Senescent cells are metabolically active.\u00a0 Our research focuses on the translational fidelity of senescent cells (misincorporation of aminoacids, frameshift and readthrough of stop codons). So far, we investigated changes in the readthrough in translation. This event is more widespread than previously believed in eukaryotes. It produces proteins that are lengthened in C-terminal and exhibit properties different from standard proteins or have a different localization. Our preliminary results show that ribosomes from senescent cells make less readthrough than non-senescent cells. We now want to study which pathways control this change, what are the ribosomal modifications responsible for this change and which role this change plays in the establishment of senescence. This research is developed in tight collaboration with Dr. Gerardo Ferbeyre.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Publications<\/h3>\n
      \n
    • Knops, E., Brakier-Gingras, L.<\/strong>, Sch\u00fblter, E., Pfister, H., Kaiser, R. et Verheyen, J. Mutational patterns in the frameshift-regulating site of HIV-1 selected by protease inhibitors. (Med. Microbiol. Immunol., 2012, 201, 213-218).<\/li>\n
    • Charbonneau, J., Gendron, K., Ferbeyre, G, et Brakier-Gingras, L. <\/strong>The 5\u2019UTR of HIV-1 full-length mRNA and the Tat viral protein modulate the programmed -1 ribosomal frameshift that generates HIV-1.(RNA, 2012, 18, 519-529).<\/li>\n
    • Brakier-Gingras, L., <\/strong>Charbonneau, J. et Butcher S.E. Targeting frameshiting in HIV. Expert Opinion on therapeutic targets. 2012, 16, 249-258)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

      Professor Contact Information D\u00e9partement de biochimie Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al Pavillon Roger-Gaudry, bureau E-519 C.P. 6128, Succ. Centre-ville Montr\u00e9al (Qu\u00e9bec) H3C 3J7 . T 514 343-6316 F 514 […]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":11439,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-687","page","type-page","status-publish","hentry"],"yoast_head":"\nL\u00e9a Brakier-Gingras - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biochimie.umontreal.ca\/en\/department\/lea-brakier-gingras\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L\u00e9a Brakier-Gingras - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Professor Contact Information D\u00e9partement de biochimie Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al Pavillon Roger-Gaudry, bureau E-519 C.P. 6128, Succ. 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