{"id":3836,"date":"2012-11-29T15:44:40","date_gmt":"2012-11-29T14:44:40","guid":{"rendered":"http:\/\/biochimie.umontreal.ca\/?page_id=3836"},"modified":"2016-11-08T15:52:45","modified_gmt":"2016-11-08T20:52:45","slug":"jean-francois-cote","status":"publish","type":"page","link":"https:\/\/biochimie.umontreal.ca\/en\/department\/jean-francois-cote\/","title":{"rendered":"Jean-Fran\u00e7ois C\u00f4t\u00e9"},"content":{"rendered":"

Accredited Professor<\/h2>\n\n\n\n
\"\"<\/td>\n\n

Contact Information<\/h2>\n

Institut de recherche cliniques de Montr\u00e9al
\n110, ave des Pins ouest
\nMontr\u00e9al (Qu\u00e9bec)
\nH2W 1R7<\/td>\n

\n

.<\/span><\/h2>\n

T<\/strong> 514 987-5647
\n<\/strong>jean-francois.cote@ircm.qc.ca<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\n

Themes<\/h2>\n

Dr. C\u00f4t\u00e9’s group focuses on understanding the role of the DOCK180\/ELMO-Rac pathway in cell migration using biochemical, cellular, genetic and structural approaches. We are currently studying the molecular players involved in myoblast fusion during the formation of skeletal muscle in order to identify the biological mechanisms regulated through DOCK180\/Rac. In addition, we are interested in understanding the molecular mechanisms controlling signaling by receptor tyrosine kinases in the induction of cell invasion and metastasis. In vivo models are used to study the role of AXL and HER-2 in the progression of breast cancer.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Publications<\/h3>\n
    \n
  • M\u00e9lanie Laurin, Jennifer Huber, Ariane Pelletier, Tarek Houalla, Morag Park, Yoshinori Fukui, Benjamin Haibe-Kains, William J. Muller and Jean-Fran\u00e7ois C\u00f4t\u00e9. \u201cThe Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis\u201d. (2013) P.N.A.S.; in revision.<\/li>\n
  • Yoran Margaron, Nadine Fradet, and Jean-Fran\u00e7ois C\u00f4t\u00e9. \u201cELMO recruits Actin Crosslinking Family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions\u201d. (2013) J Biol Chem, 288(2), p1184-1199.<\/li>\n
  • Manishha Patel*, Yoran Margaron*, Nadine Fradet, Qi Yang, Brian Wilkes, Michel Bouvier, Kay Hofmann and Jean-Fran\u00e7ois C\u00f4t\u00e9. \u201cAn evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling\u201d. (2010) Current Biology, 20(22), p2021-2027.<\/li>\n
  • Jean-Fran\u00e7ois C\u00f4t\u00e9* and Kristiina Vuori*. \u201cCell Biology. Two Lipids That Give Direction.\u201d (2009) Science, 324(5925), p346-347.<\/li>\n
  • M\u00e9lanie Laurin, Nadine Fradet, Anne Blangy, Alan Hall, Kristiina Vuori* and Jean-Fran\u00e7ois C\u00f4t\u00e9*. \u201cThe atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo\u201d (2008) P.N.A.S., 105(40), p15446-15451.<\/li>\n
  • Jean-Fran\u00e7ois C\u00f4t\u00e9, Andrea B. Motoyama, Jason A. Bush and Kristiina Vuori. \u201cA novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling\u201d (2005) Nature Cell Biology, 7(8), p797-807.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    Accredited Professor Contact Information Institut de recherche cliniques de Montr\u00e9al 110, ave des Pins ouest Montr\u00e9al (Qu\u00e9bec) H2W 1R7 . T 514 987-5647 jean-francois.cote@ircm.qc.ca Themes Dr. C\u00f4t\u00e9’s group focuses on […]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":11439,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3836","page","type-page","status-publish","hentry"],"yoast_head":"\nJean-Fran\u00e7ois C\u00f4t\u00e9 - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biochimie.umontreal.ca\/en\/department\/jean-francois-cote\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jean-Fran\u00e7ois C\u00f4t\u00e9 - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Accredited Professor Contact Information Institut de recherche cliniques de Montr\u00e9al 110, ave des Pins ouest Montr\u00e9al (Qu\u00e9bec) H2W 1R7 . 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