{"id":19892,"date":"2019-08-15T12:01:55","date_gmt":"2019-08-15T16:01:55","guid":{"rendered":"https:\/\/biochimie.umontreal.ca\/?page_id=19892"},"modified":"2019-08-15T14:58:56","modified_gmt":"2019-08-15T18:58:56","slug":"en-ressources-scientific-platforms-bmm-structural-biology-biomolecular-nmr","status":"publish","type":"page","link":"https:\/\/biochimie.umontreal.ca\/en\/resources\/en-ressources-scientific-platforms-bmm-structural-biology-biomolecular-nmr\/","title":{"rendered":"BIOMOLECULAR NMR"},"content":{"rendered":"<div class=\"one-third first \">\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/biochimie.umontreal.ca\/wp-content\/uploads\/sites\/37\/2019\/08\/photo_rmn_biomol\u00e9culaire-450x309.jpeg\" alt=\"\" class=\"alignnone wp-image-19895\" width=\"250\" height=\"172\" srcset=\"https:\/\/biochimie.umontreal.ca\/wp-content\/uploads\/sites\/37\/2019\/08\/photo_rmn_biomol\u00e9culaire-450x309.jpeg 450w, https:\/\/biochimie.umontreal.ca\/wp-content\/uploads\/sites\/37\/2019\/08\/photo_rmn_biomol\u00e9culaire-768x528.jpeg 768w, https:\/\/biochimie.umontreal.ca\/wp-content\/uploads\/sites\/37\/2019\/08\/photo_rmn_biomol\u00e9culaire-1024x704.jpeg 1024w, https:\/\/biochimie.umontreal.ca\/wp-content\/uploads\/sites\/37\/2019\/08\/photo_rmn_biomol\u00e9culaire-610x419.jpeg 610w, https:\/\/biochimie.umontreal.ca\/wp-content\/uploads\/sites\/37\/2019\/08\/photo_rmn_biomol\u00e9culaire.jpeg 1917w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><\/p>\n<\/div>\n<div class=\"two-third  \">\n<div class=\"mybutton goal   \"><a href=\"https:\/\/biochimie.umontreal.ca\/wp-content\/uploads\/sites\/37\/2018\/10\/NMR_time_request.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Reservation Form<\/a><\/div>\n<h3>Contacts<\/h3>\n<p><strong>Normand Cyr<br \/>\n<\/strong>Structural biology platform manager<br \/>\n<a href=\"mailto:normand.cyr@umontreal.ca\">normand.cyr@umontreal.ca<\/a><\/p>\n<p><strong>Pascale Legault<\/strong><br \/>\nProfessor<br \/>\n<a href=\"mailto:pascale.legault@umontreal.ca\">pascale.legault@umontreal.ca<\/a><\/p>\n<\/div>\n<hr\/>\n<h3>Description of the equipment<\/h3>\n<div class=\"togglecontainer toggle_close_all \">\n\n<div class=\"toggler extralight-border\"><span class=\"text-title\"><strong>Bruker AVANCE NEO - 500 MHz<\/strong><\/span><span class=\"toggle_icon extralight-border\"><span class=\"vert_icon extralight-border\"><\/span><span class=\"hor_icon extralight-border\"><\/span><\/span><\/div>\n<div class=\"toggle_wrap\">\n<div class=\"toggle_content\">\n<h3>Applications<\/h3>\n<p style=\"text-align: justify\">Analysis of small molecules, peptides and biomolecules of small molecular weight. Biomolecule (protein, RNA, DNA) \u2013 small molecule titrations. Rapid assessment of the quality of a biomolecular sample in order to initiate biophysical studies.<\/p>\n<p style=\"text-align: justify\">NMR tubes\u00a0: 3 or 5 mm in diameter (standard or Shigemi)<\/p>\n<p style=\"text-align: justify\">Temperature\u00a0: 0 \u2013 80 \u02daC<\/p>\n<h4 style=\"text-align: justify\">Magnet and console<\/h4>\n<p style=\"text-align: justify\">Shielded, superconducting Oxford magnet of 500 MHz (11.7 Tesla) coupled to a Bruker AVANCE NEO console.<\/p>\n<h4 style=\"text-align: justify\">Probes available<\/h4>\n<p style=\"text-align: justify\">Normally equipped with a <strong>5 mm TXI probe<\/strong> (inverse triple resonance) with automatic tuning and matching and Z-gradient capability. This probe is designed for <sup>1<\/sup>H observation with decoupling capacity of <sup>13<\/sup>C, <sup>15<\/sup>N and <sup>2<\/sup>D.<\/p>\n<p style=\"text-align: justify\">A second probe is available if needed: a <strong>5 mm QXI probe<\/strong> (inverse quadruple resonance) with automatic tuning and matching and Z-gradient capability. This probe is designed for <sup>1<\/sup>H observation with decoupling capacity of <sup>13<\/sup>C, <sup>15<\/sup>N and <sup>31<\/sup>P in the same experiment. Can also be used for <sup>13<\/sup>C, <sup>15<\/sup>N and <sup>31<\/sup>P observed experiments, albeit not optimized for that purpose.<\/p>\n<h4>Logiciels<\/h4>\n<ul>\n<li>TopSpin 4.0.3 (Linux CentOS)<\/li>\n<li>Complete Molecular Confidence suite (CMC-assist and CMC-se)<\/li>\n<li>Non-Uniform Sampling (NUS)<\/li>\n<li>Protein Dynamics Center<\/li>\n<\/ul>\n<h4>Technical support<\/h4>\n<p>Normand Cyr, Structural biology platform manager <u><a href=\"mailto:normand.cyr@umontreal.ca\">normand.cyr@umontreal.ca<\/a><\/u><\/p>\n\n<\/div>\n<\/div>\n\n<div class=\"toggler extralight-border\"><span class=\"text-title\"><strong>Bruker AVANCE NEO - 600 MHz with cryo-probe<\/strong><\/span><span class=\"toggle_icon extralight-border\"><span class=\"vert_icon extralight-border\"><\/span><span class=\"hor_icon extralight-border\"><\/span><\/span><\/div>\n<div class=\"toggle_wrap\">\n<div class=\"toggle_content\">\n<h4 style=\"text-align: justify\">Applications<\/h4>\n<p style=\"text-align: justify\">Improved sensitivity with cryo-probe usage. Ideal for multi-dimensional, triple resonance experiments typically used in structural and dynamics studies of proteins and nucleic acids.<\/p>\n<p style=\"text-align: justify\">NMR tubes\u00a0: 3 or 5 mm in diameter (standard or Shigemi) and Bruker shaped tubes (with SPU)<\/p>\n<p style=\"text-align: justify\">Temperature\u00a0: 0 \u2013 80 \u02daC<\/p>\n<h4 style=\"text-align: justify\">Magnet and console<\/h4>\n<p style=\"text-align: justify\">Superconducting Oxford magnet of 600 MHz (14.1 Tesla) coupled to a Bruker AVANCE NEO console.<\/p>\n<h4 style=\"text-align: justify\">Probes available<\/h4>\n<p style=\"text-align: justify\">Normally equipped with a <strong>TCI 5 mm cryo-probe<\/strong> (inverse triple resonance) with automatic tuning and matching, Z-gradient capability and sample positioning unit (SPU). This probe is designed for high sensitivity <sup>1<\/sup>H observation (with <sup>13<\/sup>C, <sup>15<\/sup>N and <sup>2<\/sup>D decoupling) as well as <sup>13<\/sup>C observation (with <sup>1<\/sup>H, <sup>15<\/sup>N and <sup>2<\/sup>D decoupling). The pre-amplifier for the lock signal (<sup>2<\/sup>D) is also cryo-cooled thus enabling the usage of lower percentages of deuterated solvent.<\/p>\n<p style=\"text-align: justify\">A second probe is also available on demand: a <strong>5 mm TXI probe<\/strong> (inverse triple resonance) with automatic tuning and matching and Z-gradient capability. This probe is designed for <sup>1<\/sup>H observation with decoupling capacity of <sup>13<\/sup>C, <sup>15<\/sup>N and <sup>2<\/sup>D.<\/p>\n<h4 style=\"text-align: justify\">Softwares<\/h4>\n<ul style=\"text-align: justify\">\n<li>TopSpin 4.0.3 (Linux CentOS)<\/li>\n<li>Complete Molecular Confidence suite (CMC-assist and CMC-se)<\/li>\n<li>Non-Uniform Sampling (NUS)<\/li>\n<li>Protein Dynamics Center<\/li>\n<\/ul>\n<h4>Technical support<\/h4>\n<p>Normand Cyr, Structural biology platform manager <u><a href=\"mailto:normand.cyr@umontreal.ca\">normand.cyr@umontreal.ca<\/a><\/u><\/p>\n\n<\/div>\n<\/div>\n\n<div class=\"toggler extralight-border\"><span class=\"text-title\"><strong>Bruker AVANCE NEO - 700 MHz<\/strong><\/span><span class=\"toggle_icon extralight-border\"><span class=\"vert_icon extralight-border\"><\/span><span class=\"hor_icon extralight-border\"><\/span><\/span><\/div>\n<div class=\"toggle_wrap\">\n<div class=\"toggle_content\">\n<h4 style=\"text-align: justify\">Applications<\/h4>\n<p style=\"text-align: justify\">Great resolution and sensitivity. Ideal for multi-dimensional, triple resonance experiments typically used in structural and dynamics studies of proteins and nucleic acids.<\/p>\n<p style=\"text-align: justify\">NMR tubes\u00a0: 3 or 5 mm in diameter (standard or Shigemi)<\/p>\n<p style=\"text-align: justify\">Temperature\u00a0: 0 \u2013 80 \u02daC<\/p>\n<p style=\"text-align: justify\"><strong>Magnet and console<\/strong><\/p>\n<p style=\"text-align: justify\">Shielded, superconducting Bruker Ascend magnet of 700 MHz (16.4 Tesla) coupled to a Bruker AVANCE NEO console.<\/p>\n<h4 style=\"text-align: justify\">Probes<\/h4>\n<p style=\"text-align: justify\">Normally equipped with a <strong>5 mm TXI probe<\/strong> (inverse triple resonance) with automatic tuning and matching and Z-gradient capability. This probe is designed for <sup>1<\/sup>H observation with decoupling capacity <sup>13<\/sup>C, <sup>15<\/sup>N and <sup>2<\/sup>D.<\/p>\n<p style=\"text-align: justify\">A second probe is also available on demand: a <strong>BBI 5 mm probe<\/strong> (inverse broadband) with automatic tuning and matching and Z-gradient capability. This probe enables the observation of <sup>1<\/sup>H with decoupling capacity for a single nucleus between <sup>31<\/sup>P and <sup>109<\/sup>Ag depending on the tuning. Useful for HSQC, HMQC and HMBC experiments. Can be used for the observation of <sup>13<\/sup>C, <sup>15<\/sup>N or <sup>31<\/sup>P observed experiments, albeit not optimized for that purpose.<\/p>\n<h4 style=\"text-align: justify\">Softwares<\/h4>\n<ul style=\"text-align: justify\">\n<li>TopSpin 4.0.3 (Linux CentOS)<\/li>\n<li>Complete Molecular Confidence suite (CMC-assist &amp; CMC-se)<\/li>\n<li>Non-Uniform Sampling (NUS)<\/li>\n<li>Protein Dynamics Center<\/li>\n<\/ul>\n<h4 style=\"text-align: justify\">Technical support<\/h4>\n<p style=\"text-align: justify\">Normand Cyr, Structural biology platform manager <u><a href=\"mailto:normand.cyr@umontreal.ca\">normand.cyr@umontreal.ca<\/a><\/u><\/p>\n\n<\/div>\n<\/div>\n\n\n\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Description of the equipment<\/p>\n","protected":false},"author":93,"featured_media":0,"parent":12934,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-19892","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - 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