{"id":1666,"date":"2012-07-18T14:30:34","date_gmt":"2012-07-18T13:30:34","guid":{"rendered":"http:\/\/biochimie.umontreal.ca\/?page_id=1666"},"modified":"2016-10-12T15:45:17","modified_gmt":"2016-10-12T19:45:17","slug":"stephen-michnick","status":"publish","type":"page","link":"https:\/\/biochimie.umontreal.ca\/en\/department\/stephen-michnick\/","title":{"rendered":"Stephen Michnick"},"content":{"rendered":"

Professor<\/h2>\n\n\n\n
\"\"<\/td>\n\n

Contact Information<\/h2>\n

D\u00e9partement de biochimie
\nFacult\u00e9 de M\u00e9decine
\nUniversit\u00e9 de Montr\u00e9al
\nPavillon Roger-Gaudry, room E-523
\nC.P. 6128, Succ. Centre-ville
\nMontr\u00e9al (Qu\u00e9bec)
\nH3C 3J7<\/td>\n

\n

.<\/span><\/h2>\n

P<\/strong> 514 343-5849
\n<\/strong>F<\/strong> 514 343-2210
\nstephen.michnick@umontreal.ca<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\n

Themes<\/h3>\n
    \n
  • Genomics and Proteomics<\/li>\n
  • Bioinformatics<\/li>\n
  • Cellular dynamics of macromolecules<\/li>\n
  • Structural analysis of macromolecules<\/li>\n
  • Cell signaling<\/li>\n<\/ul>\n

    How do cells work? We can pose this question in two ways first, we could ask: what is the function of a gene and second, how do genes function as ensembles. In my lab, we want to be able to test hypotheses both about how genes function and how to study their interactions at a genome-wide scale. The sequencing of some 28,000 human genes has occupied a number of labs around the world and has motivated feverish activity among biomedical researchers to understand functions of genes. However, in the absence of simple methods to establish function, these activities have not advanced significantly. We have a situation analogous to having a complete list of telephone numbers for a city, but few easy ways of linking those numbers to their owners, let alone the relationships among them. On way to define the function of a newly identified gene is to study the interactions of its product (a proteins) with proteins for which we already know their function. \u00a0We have developed experimental and theoretical methods that allow us to study how proteins form complexes with each other. Our methods allow us to determine how, when and where in the cell novel proteins interact with known proteins and what are resulting phenotypes specifically associated with a new gene. We also study how groups of proteins work as ensembles to regulate decision making by the cell. \u00a0We have posed the hypothesis that cells use a limited number of molecular strategies to respond to environmental signals to make decisions to divide, to differentiate into new forms or to die. \u00a0We are searching for these common mechanisms, which we call \u00ab logic motifs \u00bb at a genome-wide level. \u00a0We have already discovered several logic motifs that are necessary to cell survival and for which their interruptions are implicated in several diseases including cancers and diseases of development and aging.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Publications<\/h3>\n
      \n
    • Tarassov, K. Messier, V., Landry, C.R., Radinovic, S., Serna Molina, M. M., Shames, I., Malitskaya, Y., Vogel, J., Bussey, H. and S. W. Michnick (2008) An in vivo Map of the Yeast Protein Interactome Science Epub May 8.<\/li>\n
    • Stefan, E., Aquin, S., Berger, N., Landry, C., Bouvier, M., Michnick, S. W., (2007) Quantification of dynamic protein complexes using Renilla luciferase-fragment complementation applied to PKA activities in vivo. Proc Natl Acad Sci U S A, 104, 16,916-16,921.<\/li>\n
    • Michnick, S. W., Ear, P. H., Manderson, E. N., Remy, I., Stefan, E.,\u00a0 (2007)\u00a0 Universal strategies in research and drug discovery based on protein-fragment complementation assays. Nature Rev Drug Discov \u00a06, 569-582.<\/li>\n
    • MacDonald, M. L., Lamerdin, J., Owens, S., Keon, B. H., Bilter, G. K., Shang, Z., Huang, Z., Yu, H., Dias, J., Minami, T., Michnick, S. W.*, Westwick, J. K.,\u00a0 (2006)\u00a0 Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature Chem Biol \u00a02, 329-337.<\/li>\n
    • Remy, I., Montmarquette, A., Michnick, S. W.,\u00a0 (2004)\u00a0 PKB\/Akt modulates TGF-beta signalling through a direct interaction with Smad3. Nature Cell Biol \u00a06, 358-65.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

      Professor Contact Information D\u00e9partement de biochimie Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al Pavillon Roger-Gaudry, room E-523 C.P. 6128, Succ. Centre-ville Montr\u00e9al (Qu\u00e9bec) H3C 3J7 . P 514 343-5849 F 514 […]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":11439,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1666","page","type-page","status-publish","hentry"],"yoast_head":"\nStephen Michnick - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biochimie.umontreal.ca\/en\/department\/stephen-michnick\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Stephen Michnick - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Professor Contact Information D\u00e9partement de biochimie Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al Pavillon Roger-Gaudry, room E-523 C.P. 6128, Succ. 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