{"id":14985,"date":"2016-11-11T15:18:50","date_gmt":"2016-11-11T20:18:50","guid":{"rendered":"http:\/\/biochimie.umontreal.ca\/en\/?page_id=14985"},"modified":"2016-11-11T15:18:50","modified_gmt":"2016-11-11T20:18:50","slug":"daniel-lajeunesse","status":"publish","type":"page","link":"https:\/\/biochimie.umontreal.ca\/en\/department\/directories\/accredited-professors\/daniel-lajeunesse\/","title":{"rendered":"Daniel Lajeunesse"},"content":{"rendered":"

Accredited Professor<\/h2>\n\n\n\n
\"\"<\/td>\n\n

Contact Information<\/h2>\n

Centre de Recherche du CHUM
\nH\u00f4pital Notre-Dame
\nPavillon JA DeS\u00e8ve, bureau Y-2603
\n1560, est rue Sherbrooke
\nMontr\u00e9al (Qu\u00e9bec)
\nH2L 4M1<\/td>\n

\n

.<\/span><\/h2>\n

T<\/strong> 514 890-8000, poste 28914 (bureau)
\nT<\/strong> 514 890-8000, poste 28907 (laboratoire)
\nF<\/strong> 514 412-7583
\ndaniel.lajeunesse@umontreal.ca<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\n

Themes<\/h2>\n
    \n
  • Osteoarthrose<\/li>\n
  • Osseous mineralization<\/li>\n
  • Wnt signalisation<\/li>\n
  • Growth factors<\/li>\n
  • Leptin<\/li>\n<\/ul>\n
      \n
    1. Role of subchondral bone in the pathogenesis of osteoarthrosis (OA).\u00a0 Implication of IGF-1, HGF and TGF-beta 1 signaling pathways in OA osteoblasts.<\/li>\n
    2. Role of the extracellular matrix (ECM) and in particular collagen type 1 in OA bone sclerosis and abnormal mineralization.\u00a0 Role of eicosanoids in OA bone sclerosis.<\/li>\n
    3. Role of endogenous leptin production by OA osteoblasts in pathogenesis of OA and abnormal mineralisation.<\/li>\n
    4. Implication of the Wnt signaling pathway in OA pathogenesis:\u00a0 role of Dicckpof (DKK) and sclerostin (SOST) in abnormal signalisation in OA osteoblasts.<\/li>\n<\/ol>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      Publications<\/h3>\n
        \n
      • *Massicotte, F., Martel-Pelletier, J., Pelletier, J.-P., & Lajeunesse, D. : Modulation of Insulin-like Growth Factor 1 levels in human osteoarthritic subchondral bone osteoblasts.\u00a0 Bone 38, 333-341, 2006.<\/li>\n
      • Martel-Pelletier, J., Lajeunesse, D., Fahmi, H., Tardif, G., Pelletier, J.-P. : New thoughts on the pathophysiology of osteoarthritis: one more step toward new therapeutic targets.\u00a0 Current Rheumatology Reports. 8(1):30-6, 2006 (selected by the editor for reproduction in Curr. Primary Care Rep. 2:3-9, 2007).<\/li>\n
      • *Massicotte, F., Aubry, I., Martel-Pelletier, J., Pelletier, J.-P. & Lajeunesse, D.: Abnormal Insulin-like Growth Factor-1 intracellular signaling in human osteoarthritic osteoblasts. Arthritis Res Ther. 2006;8(6):R177.<\/li>\n
      • *Maxis, K., Delalandre, A., Sabouret, P. & Lajeunesse, D.: Variable production of leukotriene B4 in human osteoarthritic subchondral osteoblasts is due to altered expression of 5-lipoxygenase activating protein. Arthritis Res Ther. 2006;8(6):R181.<\/li>\n
      • *Tat, S.K., Pelletier, J.-P., Verges, J., Lajeunesse, D., Montell, E., Fahmi, H., Lavigne, M. & Martel-Pelletier, J. : Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: A basic science study. Arthritis Res Ther. 2007;9:R117.<\/li>\n
      • *Tat, S.K., Pelletier, J.-P., Lajeunesse, D., Fahmi, H., Lavigne, M., & Martel-Pelletier, J. : The Differential Expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kB ligand (RANKL) in Human Osteoarthritic Subchondral Bone Osteoblasts is an Indicator of the Metabolic State of These Diseased Cells. Clin. Expr. Rheum. 2008;26(2):295-304.<\/li>\n
      • *Tat, S.K., Pelletier, J.-P., Lajeunesse, D., Fahmi, H., Duval, N. & Martel-Pelletier, J. Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts:\u00a0 Influence of osteotropic factors.\u00a0 Bone 2008 (in press)<\/li>\n
      • Fernandes, J.C., SHI, Q., Benderdour, M., Lajeunesse, D. & *Lavigne, P.:\u00a0 An active role for soluble and membrane intercellular adhesion molecule-1 on osteoclast activity in vitro.\u00a0 Journal Bone Mineral Metabolism (In press) 2008<\/li>\n
      • Kwan Tat S., Pelletier J-P., Lajeunesse D., Duval N. et Martel-Pelletier J.: Activation of EphB4 receptor by its ligand EphB2 in human osteoarthritic subchondral bone osteoblasts\u00a0 ost\u00e9oblastes.\u00a0 Arthritis & Rheum. 2008 (in press)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

        Accredited Professor Contact Information Centre de Recherche du CHUM H\u00f4pital Notre-Dame Pavillon JA DeS\u00e8ve, bureau Y-2603 1560, est rue Sherbrooke Montr\u00e9al (Qu\u00e9bec) H2L 4M1 . T 514 890-8000, poste 28914 […]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":14887,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-14985","page","type-page","status-publish","hentry"],"yoast_head":"\nDaniel Lajeunesse - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biochimie.umontreal.ca\/en\/department\/directories\/accredited-professors\/daniel-lajeunesse\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Daniel Lajeunesse - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Accredited Professor Contact Information Centre de Recherche du CHUM H\u00f4pital Notre-Dame Pavillon JA DeS\u00e8ve, bureau Y-2603 1560, est rue Sherbrooke Montr\u00e9al (Qu\u00e9bec) H2L 4M1 . 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