{"id":14961,"date":"2016-11-11T15:06:00","date_gmt":"2016-11-11T20:06:00","guid":{"rendered":"http:\/\/biochimie.umontreal.ca\/en\/?page_id=14961"},"modified":"2016-11-11T15:06:00","modified_gmt":"2016-11-11T20:06:00","slug":"mathieu-ferron","status":"publish","type":"page","link":"https:\/\/biochimie.umontreal.ca\/en\/department\/directories\/accredited-professors\/mathieu-ferron\/","title":{"rendered":"Mathieu Ferron"},"content":{"rendered":"<h2>Accredited Professor<\/h2>\n<table>\n<tbody>\n<tr>\n<td style=\"vertical-align: middle;\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/biochimie.umontreal.ca\/wp-content\/uploads\/sites\/37\/2015\/09\/Mathieu-Ferron.jpg\" alt=\"Mathieu Ferron\" class=\"alignleft size-full wp-image-9867\" height=\"151\" width=\"226\" \/><\/td>\n<td style=\"vertical-align: top;\">\n<h2>Contact Information<\/h2>\n<p>Unit\u00e9 de recherche en physiologie int\u00e9grative et mol\u00e9culaire<br \/>\nInstitut de recherches cliniques de Montr\u00e9al (IRCM)<br \/>\n110, avenue des Pins Ouest \u2013 laboratoire 2750<br \/>\nMontr\u00e9al (Qu\u00e9bec)<br \/>\nH2W 1R7<\/td>\n<td style=\"vertical-align: top;\">\n<h2><span style=\"color: #ffffff;\">.<\/span><\/h2>\n<p><strong>T<\/strong> 514 987-5754 bureau<br \/>\n<strong>T<\/strong> 514 987-5780 labo<br \/>\n<strong>F<\/strong> 514 987-5649<br \/>\n<a href=\"mailto:mathieu.ferron@ircm.qc.ca\">mathieu.ferron@ircm.qc.ca<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table>\n<tbody>\n<tr>\n<td>\n<h2>Themes<\/h2>\n<p><strong>Physiological and pathological function of vitamin K and \u03b3-carboxylation:<\/strong><br \/>\nThe only known biological function of vitamin K is to serve as a co-factor for the \u03b3-glutamyl carboxylase (GGCX), an enzyme responsible for the conversion of glutamic acid residues (GLU) into \u03b3-carboxyglutamic acid (GLA) residues in specific secreted proteins. This posttranslational modification is found for instance in some coagulation factors (prothrombin, factor IX, etc.), in MGP, a protein implicated in tissue mineralization, and in osteocalcin, a bone-derived hormone affecting glucose metabolism. However, we still don\u2019t know all the \u03b3-carboxylated proteins and their functions. Recent findings in humans and rodents suggest that vitamin K and \u03b3-carboxylation may be involved in the control of energy metabolism and the development of obesity and diabetes. Our current goal is to address \u03b3-carboxylation function in vivo through the generation of tissue-specific knockout mice for the enzymes implicated in this process. We are also planning to characterize, in a non-bias proteomic approach, the \u201c\u03b3-carboxylome\u201d (i.e. identifying all the GLA proteins produced in tissues were the \u03b3-glutamyl carboxylase is expressed).<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Publications<\/h3>\n<ul>\n<li>Ferron, M., Lacombe, J., Germain, A., Oury, F. and Karsenty, G. (2015) GGCX and VKORC1 inhibit osteocalcin endocrine functions. J Cell Biol., 208, 761-776.<\/li>\n<li>Ferron, M., Lacombe, J. Regulation of energy metabolism by the skeleton: Osteocalcin and beyond. (2014) Arch Biochem Biophys., 562, 137-146.<\/li>\n<li>Lacombe, J., Karsenty, G., Ferron, M. (2013) In vivo analyis of the contribution of bone resorption to the control of glucose metabolism in male mice. Molecular Metabolism. 2, 498-504.<\/li>\n<li>Ferron, M. Settembre, C., Shimazu, J., Lacombe, J., Kato, S., Rawlings, D.J., Ballabio, A., Karsenty, G. (2013) A RANKL-PKC\u03b2-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts. Genes &amp; Dev. 27, 955-69.<\/li>\n<li>Ferron, M., Wei, J., Yoshizawa, T., Del Fattore, A., DePinho, R.A., Teti, A., Ducy, P. and Karsenty, G. (2010) Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism. Cell. 142, 296-308.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Accredited Professor Contact Information Unit\u00e9 de recherche en physiologie int\u00e9grative et mol\u00e9culaire Institut de recherches cliniques de Montr\u00e9al (IRCM) 110, avenue des Pins Ouest \u2013 laboratoire 2750 Montr\u00e9al (Qu\u00e9bec) H2W [&hellip;]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":14887,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-14961","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Mathieu Ferron - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biochimie.umontreal.ca\/en\/department\/directories\/accredited-professors\/mathieu-ferron\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mathieu Ferron - 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