{"id":14893,"date":"2016-11-11T14:24:45","date_gmt":"2016-11-11T19:24:45","guid":{"rendered":"http:\/\/biochimie.umontreal.ca\/en\/?page_id=14893"},"modified":"2016-11-11T16:15:33","modified_gmt":"2016-11-11T21:15:33","slug":"daniel-sinnett","status":"publish","type":"page","link":"https:\/\/biochimie.umontreal.ca\/en\/department\/directories\/accredited-professors\/daniel-sinnett\/","title":{"rendered":"Daniel Sinnett"},"content":{"rendered":"

Accredited Professor<\/h2>\n\n\n\n
\"\"<\/td>\n\n

Contact Information<\/h2>\n

Centre de recherche
\nService d’h\u00e9matologie et d’oncologie
\nCHU Sainte-Justine
\n3175, chemin de la C\u00f4te Ste-Catherine
\nMontr\u00e9al (Qu\u00e9bec)
\nH3T 1C5<\/td>\n

\n

.<\/span><\/h2>\n

T<\/strong> 514 345-4931, poste 2990
\nF<\/strong> 514 345-4731
\ndaniel.sinnett@umontreal.ca<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\n

Themes<\/h2>\n

Leukemogenesis and tumor suppressor genes<\/strong><\/p>\n

Oncogenesis is a multistep process that involves the accumulation of mutations in oncogenes and tumor suppressor genes.\u00a0The short arm of chromosome 12 is affected by genetic rearrangements leading to the loss of genetic material in a wide range of hematological malignancies.\u00a0It has been shown that chromosome 12p12.3 is associated with a putative tumor suppressor that may play an important in childhood leukemogenesis as well as in certain solid neoplasias.\u00a0 The transcription factor ETV6 is a suitable candidate gene.\u00a0In this project, we propose to characterize ETV6 by identifying the genes targeted by this transcription repressor in order to build the corresponding regulatory network and by determining the nature of the protein partners involved in the repression complex.<\/p>\n

Genetic determinants of childhood leukemia<\/strong><\/p>\n

Sporadic cancer is a complex disease, where the effect of the environment is modulated by a series of genes whose allelic forms represent functional polymorphisms (DNA variants).\u00a0According to this model, the origin of childhood leukemia could be explained by a combination of genetic susceptibility factors and environmental exposures.\u00a0Because of the much shorter latency period, the study of pediatric tumors allows a more realistic evaluation of the input of genetic factors and environment exposures during vulnerable periods of development (foetal life and young childhood).\u00a0In this project, we propose to identify the genetic factors underlying the individual\u2019s susceptibility to childhood leukemia by performing genetic epidemiology studies.<\/p>\n

Regulatory genomics<\/strong><\/p>\n

Genetic diversity in regulatory sequences might lead to allelic variation in gene expression levels (quantitative changes).\u00a0Such variability could alter tightly regulated biological pathways (e.g. cell cycle) and then contribute to change in disease risk.\u00a0In this project, we propose to determine the extent of genetic variants in regulatory regions and to validate the functional impact of these variants.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Publications<\/h3>\n
    \n
  • Boily G, Larose J, Langlois S, Sinnett D.\u00a0 Identification of transcripts modulated by ETV6 expression. Br J Haematol. 2007 136:48-62.<\/li>\n
  • Healy J, B\u00e9langer H, Beaulieu P, Larivi\u00e8re M, Labuda D, Sinnett D. Promoter SNPs in G1\/S checkpoint regulators and their impact on the susceptibility to childhood leukemia. Blood. 2007 109:683-92.<\/li>\n
  • B\u00e9langer H, Beaulieu P, Moreau C, Labuda D, Hudson TJ, Sinnett D.\u00a0 Functional promoter SNPs in cell cycle checkpoint genes. Hum Mol Genet. 2005 14:2641-8.<\/li>\n
  • Krajinovic M, Lamothe S, Labuda D, Lemieux-Blanchard E, Theoret Y, Moghrabi A, Sinnett D.\u00a0 Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.\u00a0 Blood. 2004 103:252-7.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    Accredited Professor Contact Information Centre de recherche Service d’h\u00e9matologie et d’oncologie CHU Sainte-Justine 3175, chemin de la C\u00f4te Ste-Catherine Montr\u00e9al (Qu\u00e9bec) H3T 1C5 . T 514 345-4931, poste 2990 F […]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":14887,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-14893","page","type-page","status-publish","hentry"],"yoast_head":"\nDaniel Sinnett - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biochimie.umontreal.ca\/en\/department\/directories\/accredited-professors\/daniel-sinnett\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Daniel Sinnett - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Accredited Professor Contact Information Centre de recherche Service d’h\u00e9matologie et d’oncologie CHU Sainte-Justine 3175, chemin de la C\u00f4te Ste-Catherine Montr\u00e9al (Qu\u00e9bec) H3T 1C5 . 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