{"id":14884,"date":"2016-11-11T14:23:15","date_gmt":"2016-11-11T19:23:15","guid":{"rendered":"http:\/\/biochimie.umontreal.ca\/en\/?page_id=14884"},"modified":"2016-11-11T14:23:24","modified_gmt":"2016-11-11T19:23:24","slug":"pierre-thibault","status":"publish","type":"page","link":"https:\/\/biochimie.umontreal.ca\/en\/department\/directories\/accredited-professors\/pierre-thibault\/","title":{"rendered":"Pierre Thibault"},"content":{"rendered":"

Accredited Professor<\/h2>\n\n\n\n
\"\"<\/td>\n\n

Contact Information<\/h2>\n

Institut de recherche en immunologie et canc\u00e9rologie
\nUniversit\u00e9 de Montr\u00e9al
\nPavillon Marcelle-Coutu, bureau 2306-17
\nC.P. 6128, Succ. Centre-ville
\nMontr\u00e9al (Qu\u00e9bec)
\nH3C 3J7<\/td>\n

\n

.<\/span><\/h2>\n

T<\/strong> 514 343-6910
\nF<\/strong> 514 343-6843
\npierre.thibault@umontreal.ca
\n<\/a>Site web<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\n

Themes<\/h2>\n

Our research program focuses on the development and application of proteomics and bioanalytical mass spectrometry to the identification of trace-level proteins in complex cell extracts. Our research efforts bring a multidisciplinary team approach using methods and techniques from bioanalytical chemistry, protein chemistry, biochemistry and cellbiology.<\/p>\n

More specifically, our research interests span from the development of cell fractionation methods and protein enrichment techniques for phospho- and glycoproteins to the coupling of multidimensional capillary liquid chromatography to mass spectrometry and its application to the identification of post-translational modifications (sites and stoechiometry). We are also developing chemometric and bioinformatics tools for data mining of peptides in complex protein digests. These different tools are used in proteomics research programs to gain further insights to complex cell biology paradigms such as organelle biogenesis (phagosome and endosome), cell signalling in cancer, and the identification of peptides presented by the major histocompatibility complexproteins.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Publications<\/h3>\n
    \n
  • J. Saba, E. Bonneil, C. Pomies, K. Eng, P.Thibault, \u201cEnhanced Sensitivity in Proteomics Experiments Using FAIMS Coupled to a Hybrid Linear Ion Trap\/Orbitrap Mass Spectrometer\u201d, J. Proteome Res., 8, 3355\u20133366 (2009)<\/li>\n
  • P. Drogaris, Y. Le Blanc, J. Fitzgerald, N. Lowndes, A. Verreault, P. Thibault, \u201cEnhanced protein detection using a novel trapping mode on a hybrid quadrupole-linear ion trap Q-Trap)\u201d, Anal. Chem., 81, 6300-6309 (2009)<\/li>\n
  • M. Boutin, C. Berthelette, F. G. Gervais, M.-B. Scholand, J. Hoidal, M. F. Leppert, K. P. Bateman, P. Thibault, \u201cHigh Sensitivity NanoLC-MS\/MS Analysis of Urinary Desmosine and Isodesmosine\u201d, Anal. Chem, 81, 1881-1887 (2009)<\/li>\n
  • M. Trost, L. English, M. Courcelles, M. Desjardins, P. Thibault, \u201cDeciphering the Phagosomal Proteome in Interferon-g Activated Macrophages\u201d, Immunity, 30, 143-154 (2009)<\/li>\n
  • Bendall S.C., Hughes C., Campbell J.L., Stewart MH, Pittock P., Liu S., Bonneil E., Thibault P., Bhatia M., Lajoie G.A., \u201cAn enhanced mass spectrometry approach reveals human embryonic stem cell growth factors in culture\u201d, Mol. Cell. Proteomics, 8, 421-432 (2009)<\/li>\n
  • M. Gharib, M. Marcantonio, S.G. Lehmann, M. Courcelles, S. Meloche, A. Verreault, P. Thibault, \u201cArtifactual O-sulfation of silver-stained proteins: Implications for the assignment of phosphorylation and sulfation sites\u201d, Mol. Cell. Proteomics, 8, 506-518 (2009)<\/li>\n
  • P. Drogaris, H. Wurtele, H. Masumoto, A. Verreault, P. Thibault, \u201cComprehensive profiling of histone modifications using a label-free approach and its applications in determining structure-function relationships\u201d, Anal. Chem, 80, 6698-6707 (2008)<\/li>\n
  • A. Carri\u00e8re, M. Cargnello, L.-A. Julien, H. Gao, E. Bonneil, P. Thibault, P. P. Roux, \u201cOncogenic MAPK Signaling Regulates mTORC1 Assembly by Promoting Raptor Phosphorylation via ERK and RSK\u201d, Current Biol, 18, 1269-1277 (2008)<\/li>\n
  • Y. Tang, M. A Holbert, H. Wurtele, K. Meeth, W. Rocha, M. Gharib, E. Jiang, P. Thibault, A.Verreault, P. A Cole, R. Marmorstein, \u201cFungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300\/CBP\u201d, Nature Struct. Mol. Biol., 15, 738-745 (2008)<\/li>\n
  • M. Marcantonio, M. Trost, M. Courcelles, M. Desjardins, P. Thibault, \u201cCombined enzymatic and data mining approaches for comprehensive phosphoproteome analyses; application to cell signaling events of interferon-\u03b3 stimulated macrophages\u201d, Mol Cell Proteomics, 7, 645-660 (2008)<\/li>\n
  • M.-H. Fortier, E. Caron, M.-P. Hardy, G. Voisin, S. Lemieux, C. Perreault, P. Thibault, \u201cThe MHC I immunopeptidome is moulded by the transcriptome\u201d, J. Exp. Med., 205, 595-610 (2008)<\/li>\n
  • C.A. Smith, K.M. Lau, Z. Rahmani, S. E. Dho, G. Brothers, Y. Min She, D. M. Berry, E. Bonneil, P. Thibault, F. Schweisguth, R. Le Borgne, C.J. McGlade, \u201caPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb\u201d, EMBO J., 26, 468-480 (2007)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    Accredited Professor Contact Information Institut de recherche en immunologie et canc\u00e9rologie Universit\u00e9 de Montr\u00e9al Pavillon Marcelle-Coutu, bureau 2306-17 C.P. 6128, Succ. Centre-ville Montr\u00e9al (Qu\u00e9bec) H3C 3J7 . T 514 343-6910 […]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":14887,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-14884","page","type-page","status-publish","hentry"],"yoast_head":"\nPierre Thibault - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biochimie.umontreal.ca\/en\/department\/directories\/accredited-professors\/pierre-thibault\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pierre Thibault - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Accredited Professor Contact Information Institut de recherche en immunologie et canc\u00e9rologie Universit\u00e9 de Montr\u00e9al Pavillon Marcelle-Coutu, bureau 2306-17 C.P. 6128, Succ. 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