{"id":13528,"date":"2016-05-30T14:26:02","date_gmt":"2016-05-30T13:26:02","guid":{"rendered":"http:\/\/biochimie.umontreal.ca\/en\/?page_id=13528"},"modified":"2016-10-12T15:45:16","modified_gmt":"2016-10-12T19:45:16","slug":"michel-bouvier","status":"publish","type":"page","link":"https:\/\/biochimie.umontreal.ca\/en\/department\/michel-bouvier\/","title":{"rendered":"Michel Bouvier"},"content":{"rendered":"<h2>Professor<\/h2>\n<table>\n<tbody>\n<tr>\n<td style=\"vertical-align: middle\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/biochimie.umontreal.ca\/wp-content\/uploads\/sites\/37\/2012\/06\/MBouvier-150x150.jpg\" alt=\"MBouvier\" class=\"alignnone size-thumbnail wp-image-12340\" height=\"150\" width=\"150\" \/><\/td>\n<td>\n<h2>Contact Information<\/h2>\n<p><em><strong><span id=\"result_box\" class=\"short_text\" lang=\"en\"><span class=\"\">Principal Investigator<\/span><\/span><br \/>\n<\/strong><\/em>Institut de Recherche en Immunologie et en Canc\u00e9rologie<br \/>\nPavillon Marcelle-Coutu, room 4305<br \/>\nUniversit\u00e9 de Montr\u00e9al<br \/>\nC.P. 6128, Succ. Centre-ville<br \/>\nMontr\u00e9al (Qu\u00e9bec)<br \/>\nH3C 3J7<\/td>\n<td>\n<h2><span style=\"color: #ffffff\">.<\/span><\/h2>\n<p><strong>P<\/strong> 514\u00a0343-6319<br \/>\n<strong>F<\/strong> 514 343-6843<br \/>\n<a href=\"mailto:michel.bouvier@umontreal.ca\">michel.bouvier@umontreal.ca<\/a><br \/>\n<a href=\"https:\/\/sites.google.com\/site\/bouvierlab\/\" target=\"_blank\">WWW<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table>\n<tbody>\n<tr>\n<td>\n<h2>Themes<\/h2>\n<ul>\n<li>Cell Signalling and Molecular Pharmacology<\/li>\n<li>Cellular Dynamics of Protein-Protein Interactions<\/li>\n<\/ul>\n<p>Dr. Dr Bouvier\u2019s team is composed of professional research coordinators, post-doctoral fellows, graduate students and research assistants. The research program focuses on the molecular mechanisms controlling the function of the largest family of drug targets, the G protein-coupled receptors (GPCR). Using a combination of biochemical, molecular and cell biology and biophysical methods the projects aimed at studying the dynamics of the protein-protein interactions involved in GPCR-mediated signal propagation.\u00a0 Dissecting the molecular basis underlying signalling selectivity and efficacy of GPCR has direct implication for the development of innovative approaches for the discovery of new drugs.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Publications<\/h3>\n<ul>\n<li>Breton B, Sauvageau \u00c9, Zhou J, Bonin H, Le Gouill C &amp; <strong>Bouvier M<\/strong>. (2010) Multiplexing of multicolor bioluminescence resonance energy transfer. <strong> J.,<\/strong> 99(12):4037-4046<\/li>\n<li>Quoyer J, Janz JM, Luo J, Ren Y, Armando S, Lukashova V, Benovic JL, Carlson KE, Hunt SW &amp; <strong>Bouvier M.<\/strong> (2013). Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. <strong>Proc Natl Acad Sci USA.<\/strong> 110(52):5088-97.<\/li>\n<li>Armando S, Quoyer J, Lukashova V, Maiga A, Percherancier Y, Heveker N, Pin JP, Pr\u00e9zeau L, <strong>Bouvier M.<\/strong> (2014). The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and \u03b2 <strong>FASEB J.<\/strong> 28(10):4509-4523.<\/li>\n<li>Sauvageau, E., Rochdi, D.M., Oueslati, M., Hamdan, F.H., Percherancier, Y., Simpson, J.C., Pepperkok, R., and <strong>Bouvier, M.<\/strong> (2014). CNIH4 interacts with newly synthesized GPCR and control their export form the endoplasmic reticulum. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24405750\"><strong>Traffic,<\/strong><\/a> 15(4):383-400.<\/li>\n<li>Paradis, J., Roux, P. and <strong>Bouvier, M<\/strong>. (2015). Receptor sequestration in response to barrestin-2 phosphorylation governs steady-state levels of GPCR cell surface expression. <strong>Proc Natl Acad Sci USA<\/strong>. 112(37):E5160-8<\/li>\n<\/ul>\n<p>A complete list of publication: can be found at:<\/p>\n<p><a href=\"http:\/\/scholar.google.com\/citations?hl=fr&amp;user=jWcM8YoAAAAJ\"><strong>http:\/\/scholar.google.com\/citations?hl=fr&amp;user=jWcM8YoAAAAJ<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Professor Contact Information Principal Investigator Institut de Recherche en Immunologie et en Canc\u00e9rologie Pavillon Marcelle-Coutu, room 4305 Universit\u00e9 de Montr\u00e9al C.P. 6128, Succ. Centre-ville Montr\u00e9al (Qu\u00e9bec) H3C 3J7 . P [&hellip;]<\/p>\n","protected":false},"author":92,"featured_media":0,"parent":11439,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-13528","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Michel Bouvier - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biochimie.umontreal.ca\/en\/department\/michel-bouvier\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Michel Bouvier - D\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Professor Contact Information Principal Investigator Institut de Recherche en Immunologie et en Canc\u00e9rologie Pavillon Marcelle-Coutu, room 4305 Universit\u00e9 de Montr\u00e9al C.P. 6128, Succ. 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