Marlene Oeffinger

Associated Professor

Contact Information

Institut de recherches cliniques de Montréal
110, avenue des Pins ouest
Montréal (Québec)
H2W 1R7

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P 514 987-5668
Marlene.Oeffinger@ircm.qc.ca
WWW

Themes

We study the regulation and dynamics of RNA maturation pathways. Our main focus is to determine the temporal and spatial assembly and coordination of RNA maturation factors, as well as to identify the underlying control mechanisms that drive the processing, modification and assembly of different RNAs in the budding yeast S.cerevisiae and humans. We combine proteomic, biochemical and computational approaches to build a dynamic picture of RNA maturation pathways in different cellular contexts and organisms to yield important information on how RNA maturation is linked to other cellular processes including DNA damage and repair pathways, development as well as onset of various diseases such as Alzheimer’s Disease and ALS.